3.4.22.10: streptopain

This is an abbreviated version!
For detailed information about streptopain, go to the full flat file.

Word Map on EC 3.4.22.10

3.4.22.10

speb

streptococci

glomerulonephritis

zymogen

fasciitis

superantigens

streptolysin

nephritogenic

streptokinase

poststreptococcal

scarlet

apsgn

shock-like

Reaction

preferential cleavage with hydrophobic residues at P2, P1 and P1' =

Synonyms

EC 3.4.4.18, IdeS, IgG-degrading enzyme of Streptococcus pyogenes, interleukin-1beta convertase, More, proteinase, streptococcal, pyrogenic exotoxin B, SCP, SpcCEP, Spe B, SPE B protease, SPE B/SCP, SpeB, SPP, Steptococcus proteinase, streptococcal cysteine protease, Streptococcal cysteine proteinase, streptococcal erythrogenic toxin B, streptococcal proteinase, streptococcal pyogenic exotoxin B, streptococcal pyrogenic exotoxin B, streptococcal pyrogenic exotoxin B/cysteine protease, Streptococcus peptidase A, Streptococcus protease, streptopain

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.10 streptopain

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
6	Activating Compound
168	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
5	Crystallization (Commentary)
2	Expression
12	General Information
5	General Stability
1	IC50 Value
60	Inhibitors
10	kcat/KM [mM/s]
1	Ki Value [mM]
34	KM Value [mM]
7	Localization
2	Metals/Ions
28	Molecular Weight [Da]
68	Natural Substrates/ Products (Substrates)
70	Organism
11	PDB ID
7	pH Optimum
1	pH Stability
15	Posttranslational Modification
37	Protein Variants
15	Purification (Commentary)
3	Reaction
1	Reaction Type
66	Reference
2	Renatured (Commentary)
2	Specific Activity [micromol/min/mg]
2	Storage Stability
165	Substrates and Products (Substrate)
13	Subunits
85	Synonyms
10	Temperature Optimum [°C]
4	Temperature Stability [°C]
32	Turnover Number [1/s]

Inhibitors

print visible entries

print all entries

Inhibitors on EC 3.4.22.10 - streptopain

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

back to the top

Go to Inhibitor Search

(S)-1-azido-2-tosylamino-hexane

Streptococcus pyogenes

-

moderate inhibitor of IdeS

(S)-1-azido-3-methyl-2-tosylamino-butane

Streptococcus pyogenes

-

moderate inhibitor of IdeS

(S)-1-azido-3-phenyl-2-tosylamino-propane

Streptococcus pyogenes

-

moderate inhibitor of IdeS

(S)-3-tosylamino-1-heptanal

Streptococcus pyogenes

-

strong inhibitory activity

(S)-3-tosylamino-heptane-1-nitrile

Streptococcus pyogenes

-

the compound shows some inhibition of IdeS

(S)-4-methyl-3-tosylamino-1-pentanal

Streptococcus pyogenes

-

strong inhibitory activity

(S)-4-phenyl-3-tosylamino-1-butanal

Streptococcus pyogenes

-

strong inhibitory activity

(S)-7-tert-butoxycarbonylamino-3-tosylamino-1-heptanal

Streptococcus pyogenes

-

strong inhibitory activity

1,3-Dibromoacetone

Streptococcus sp.

-

rapid and complete loss of activity

2,4-dinitrofluorobenzene

Streptococcus sp.

-

-

acetonitrile

Streptococcus sp.

-

mixed type

acetyl-Ala-Gln-Ile-(S)-2,6-diaminohexanal

Streptococcus pyogenes

-

-

benzyloxycarbonyl-Ala-Ala-CHN2

Streptococcus sp.

-

-

benzyloxycarbonyl-Ala-Ala-Pro-CHN2

Streptococcus sp.

-

-

benzyloxycarbonyl-Ala-Phe-Ala-CHN2

Streptococcus sp.

-

-

benzyloxycarbonyl-Asn-Val-Gly-CHN2

Streptococcus sp.

-

inhibition of protease activity, no influence on the superantigenic properties of the enzyme

Benzyloxycarbonyl-Gly-Phe

Streptococcus sp.

-

competitive against benzyloxycarbonyl-Phe-Tyr

benzyloxycarbonyl-Leu-Val-Gly-CHN2

Streptococcus pyogenes

-

inhibits kininogen degradation

Benzyloxycarbonyl-Phe-Ala-CHN2

Streptococcus sp.

-

-

benzyloxycarbonyl-Phe-Gly-CHN2

Streptococcus sp.

-

-

benzyloxycarbonyl-Phe-Gly-Phe-CHN2

Streptococcus sp.

-

-

Cu2+

Streptococcus pyogenes

-

Cu2+ inhibits the proteolytic activity of mature SpeB

dimethyl sulfoxide

Streptococcus sp.

-

competitive

E-64

show

E64

Streptococcus pyogenes

-

i.e. trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

Gly-Phe-CHN2

Streptococcus sp.

-

-

HgCl2

show

iodoacetamide

Streptococcus sp.

-

-

iodoacetate

Streptococcus pyogenes

-

irreversible inhibitor

iodoacetic acid

Streptococcus sp.

-

-

L-trans-epoxysuccinyl-leucylamido(4-guanidino)butane

Streptococcus pyogenes

-

-

methyliodine

Streptococcus sp.

-

-

N-(N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl)-agmatine

Streptococcus pyogenes

-

-

N-[N-(L-3-transcarboxyirane-2-carbonyl)-L-leucyl]agmatine

Streptococcus pyogenes M1 GAS

-

Nalpha-benzyloxycarbonyl-Phe-Phe

Streptococcus sp.

-

strong inhibition of hydrolysis of Nalpha-benzyloxycarbonyl-Phe-Tyr

NEM

Streptococcus sp.

-

-

Sodium tetrathionate

Streptococcus sp.

-

-

Spe B pro-peptide

Streptococcus pyogenes

-

specific inhibition of the mature enzyme, secondary structure and SpeB binding analysis, inhibition modeling and mechanism, overview

-

Spi

Streptococcus pyogenes

-

specific enzyme pro-peptide analogue inhibitor, purification from Streptococcus pyogenes, secondary structure and SpeB binding analysis, inhibition modeling and mechanism, overview

-

sulfite

Streptococcus sp.

-

-

tosyl-L-lysine chloromethyl ketone

Streptococcus pyogenes

-

irreversible inhibitor

tosyl-L-phenylalanine chloromethyl ketone

Streptococcus pyogenes

-

irreversible inhibitor

Tosyl-norleucine-Phe

Streptococcus sp.

-

competitive against benzyloxycarbonyl-norleucine-Phe

trans-epoxysuccinyl-L-leucylamido(4-guanidino)butane

Streptococcus pyogenes

-

-

trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane

show

Z-LVG-CHN2

Streptococcus pyogenes

-

irreversible inhibitor

Zn2+

Streptococcus pyogenes

-

Zinc inhibits the proteolytic activity of mature SpeB

additional information

show

-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)