3.4.22.10: streptopain

This is an abbreviated version!
For detailed information about streptopain, go to the full flat file.

Word Map on EC 3.4.22.10

Reaction

preferential cleavage with hydrophobic residues at P2, P1 and P1' =

Synonyms

More, Streptococcus peptidase A, Streptococcus protease, EC 3.4.4.18, Streptococcal cysteine proteinase, Steptococcus proteinase, proteinase, streptococcal, SCP, Spe B, streptococcal erythrogenic toxin B, streptococcal pyrogenic exotoxin B, SPP, SpeB, streptococcal proteinase, interleukin-1beta convertase, pyrogenic exotoxin B, streptococcal pyrogenic exotoxin B/cysteine protease, SPE B/SCP, SPE B protease, streptococcal cysteine protease, IdeS, IgG-degrading enzyme of Streptococcus pyogenes, SpcCEP, streptococcal pyogenic exotoxin B, streptopain

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.10 streptopain

General Information

General Information on EC 3.4.22.10 - streptopain

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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
malfunction
-
wild type strain efficiently translocates across the epithelial monolayer along with cleavage of occludin and E-cadherin. Deletion of the speB gene compromises those activities. Destabilization of the junctional proteins is relieved in cells infected with the speB mutant, as compared with those infected with the wild type
metabolism