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alpha(S1)-casein + H2O
?
-
-
-
?
alpha-lactalbumin + H2O
?
alpha1-casein + H2O
Fragments of alpha1-casein
-
-
-
-
?
alpha1-casein + H2O
fragments of alphas1-casein
-
-
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
beta-Casein + H2O
Fragments of beta-casein
beta-lactoglobulin + H2O
?
-
-
-
-
?
Bovine serum albumin + H2O
?
casein + H2O
hydrolyzed casein
Insulin B-chain + H2O
Fragments of insulin B-chain
-
-
-
?
kappa-Casein + H2O
Fragemnts of kappa-casein
-
-
-
-
?
kappa-casein + H2O
fragments of kappa-casein
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
N-succinyl-Ala-Ala-Pro-Phe-4-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
synthetic substrate
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
Suc-Ala-Glu-Pro-Phe-p-nitroanilide + H2O
?
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
?
Succinyl-Ala-Glu-Pro-Phe 4-nitroanilide + H2O
?
Succinyl-Ala-Gly-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-His-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Ile-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Leu-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Lys-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Phe-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Trp-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
additional information
?
-
alpha-lactalbumin + H2O
?
-
-
-
-
?
alpha-lactalbumin + H2O
?
-
-
-
-
?
alpha1-casein + H2O
?
-
-
-
-
?
alpha1-casein + H2O
?
-
-
-
-
?
alphas1-casein + H2O
?
-
-
-
-
?
alphas1-casein + H2O
?
-
-
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
specificity of the enzyme for the Arg22-Phe23 bond
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
specificity of the enzyme for the Arg22-Phe23 bond
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
-
-
-
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
-
the product spectrum depends on water activity and salt concentration
?
alphas1-Casein + H2O
Fragments of alphas1-casein
-
-
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
specificity of the enzyme for Lys3-His4 bond
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
specificity of the enzyme for Lys3-His4 bond
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
-
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the wild-type enzyme of strain SK11, cleaves bonds 16-17 and 17-18, the mutant enzyme lacking the loop 238-388 is highly specific for bond 21-22
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
PI-type proteinase of subsp. cremoris strain HP cleaves the bonds 8-9, 9-10, 13-14, the PIII- type proteinase of subsp. cremoris strain AM1 cleaves bonds 16-17, 17-18, 21-22
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
-
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the wild-type enzyme of strain SK11, cleaves bonds 16-17 and 17-18, the mutant enzyme lacking the loop 238-388 is highly specific for bond 21-22
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
-
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
alphas1-Casein fragment 1-23 + H2O
Fragments of alphas1-casein fragment 1-23
-
the strains of Lactococcus lactis can be devided into seven groups according to the cleavage pattern of this substrate: strains US3, AM1, SK11 possess PIII-type proteinases, strains WG2, C13, K14, Z8, H61, FD21, HP possess PI-type proteinases, strains E8, AM2, NCDO 763, UC 317 possess proteinases of an intermediate type
-
-
?
azocasein + H2O
?
-
-
-
-
?
azocasein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
preferred substrate
-
-
?
beta-casein + H2O
?
-
preferred substrate
-
-
?
beta-casein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
-
-
-
?
beta-casein + H2O
?
-
-
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
shows proteolytic activity only under in vivo conditions
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
-
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
-
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
-
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
-
subsp. lactis MG611, more than 100 different fragments
?
beta-Casein + H2O
Fragments of beta-casein
-
PIII-type proteinase of subsp. cremoris AM1 preferentially cleaves 16 peptide bonds, the cleavage sites are primarily Gln-X or Glu-X, mostly a large hydrophobic residue is part of the cleavable position, a hydrophobic residue is frequently at position P2, sometimes also at P2', one or more side chains in P2-P3 or P2'-P3' are negetively charged
-
-
?
beta-Casein + H2O
Fragments of beta-casein
-
-
-
-
?
Bovine serum albumin + H2O
?
-
-
-
-
?
Bovine serum albumin + H2O
?
-
-
-
-
?
casein + H2O
?
-
-
-
-
?
casein + H2O
?
-
nitrogen nutrition mechanism of lactic streptococci, process in cheese ripening
-
-
?
casein + H2O
hydrolyzed casein
-
-
-
?
casein + H2O
hydrolyzed casein
-
hydrolysis of alpha-s1-, beta- and kappa-casein, alpha-s1-casein which is normally resistant to lactocepin I activity is rapidly hydrolyzed in presence of polyethylene glycol 20000
-
?
casein + H2O
hydrolyzed casein
-
-
-
-
?
kappa-casein + H2O
fragments of kappa-casein
-
specificity of the enzyme for Phe105-Met106 bond
-
-
?
kappa-casein + H2O
fragments of kappa-casein
-
specificity of the enzyme for Phe105-Met106 bond
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
Methoxysuccinyl-Arg-Pro-Tyr 4-nitroanilide + H2O
?
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
N-succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe 4-nitroanilide + H2O
succinyl-Ala-Ala-Pro-Phe + 4-nitroaniline
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
?
-
-
-
-
?
succinyl-Ala-Ala-Pro-Phe-p-nitroanilide + H2O
?
-
synthetic substrate
-
-
?
Succinyl-Ala-Glu-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Succinyl-Ala-Glu-Pro-Phe 4-nitroanilide + H2O
?
-
-
-
-
?
Usp 45 + H2O
?
-
a secreted 60 kDa protein of Lactococcus lactis
-
-
?
Usp 45 + H2O
?
-
a secreted 60 kDa protein of Lactococcus lactis
-
-
?
additional information
?
-
-
no substrate: Leu-4-nitroanilide
-
-
?
additional information
?
-
-
no substrate: Leu-4-nitroanilide
-
-
?
additional information
?
-
-
proline is the preferred residue at the cleavage site. No substrate: kappa-casein
-
-
?
additional information
?
-
-
proline is the preferred residue at the cleavage site. No substrate: kappa-casein
-
-
?
additional information
?
-
-
overview, specificity of wild-type SK11 proteinase and its mutants as compared to strain Wg2
-
-
?
additional information
?
-
-
subsp. lactis NCDO 763 prefers hydrophilic amino acids in P4, proline in P2 and hydrophilic amino acids in P1
-
-
?
additional information
?
-
-
subsp. lactis NCDO 763 prefers hydrophilic amino acids in P4, proline in P2 and hydrophilic amino acids in P1
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
PI-type proteinase hydrolyzes beta- casein and kappa-casein, PIII-type proteinase hydrolyzes beta-casein and kappa-caein with different bond-specificities and alpahs1-casein
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
overview, specificity of wild-type SK11 proteinase and its mutants as compared to strain Wg2
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?
additional information
?
-
-
comparison of the amino acid sequences of the substrate-binding regions
-
-
?
additional information
?
-
-
the activity of PIII-type proteinases increases with the hydrophobicity of the P3-side chain, PI-type proteinases have the lowest activity with Glu at P3
-
-
?