3.4.21.95: Snake venom factor V activator

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Word Map on EC 3.4.21.95

Reaction

Fully activates human clotting factor V by a single cleavage at the Trp-Tyr-Leu-Arg1545!Ser-Asn-Asn-Gly bond. Cattle, but not rabbit, factor V is cleaved, and no other proteins of the clotting system are attacked. Esterase activity is observed on Bz-Arg-OEt and Tos-Arg-OMe, and amidase activity on Phe-pipecolyl-Arg-NHPhNO2 =

Synonyms

Factor V-activating enzyme, RVV-V, Factor V activator, Factor V-activating proteinase alpha, Factor V-activating proteinase gamma, Snake venom factor V activator alpha, Snake venom factor V activator gamma, VLFVA, Human blood coagulation Factor V activating enzymes, FV activating enzymes, LVV-V, blood coagulation factor V-activating proteinase, Russell's viper venom factor V (FV) activator, RVV-Vgamma, VLCII, coagulant serine proteinase, VSPF5, Russell's viper venom factor V activator

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.95 Snake venom factor V activator