3.4.21.92: Endopeptidase Clp

This is an abbreviated version!
For detailed information about Endopeptidase Clp, go to the full flat file.

Reaction

Hydrolysis of proteins to small peptides in the presence of ATP and Mg2+. alpha-Casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolysed (such as succinyl-Leu-Tyr-/-NHMec, and Leu-Tyr-Leu-/-Tyr-Trp, in which cleavage of the -Tyr-/-Leu- and -Tyr-/-Trp bonds also occurs) =

Synonyms

ATP-dependent caseinolytic protease, ATP-dependent Clp protease, ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, BsClpP, Caseinolytic protease, CLP, Clp protease, Clp proteolytic subunit, ClpA, ClpAP, ClpAP protease, ClpB, ClpC, ClpC ATPase, ClpC1, ClpCP protease, ClpCP3/R protease, ClpE, ClpP, ClpP Peptidase, ClpP Protease, ClpP protease complex, ClpP1, ClpP1 protease, ClpP1P2, ClpP2, ClpP2 protease, ClpP3, ClpP3/R complex, ClpQ, ClpR, ClpS1, ClpX, ClpX2, ClpXP, ClpXP protease, ClpY, CplC, endopeptidase Clp, endopeptidase Ti, Heat shock protein F21.5, heat-shock protease ClpP, nClpP7, nClpP8, PfClpP, Protease Ti, stress protein G7

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.92 Endopeptidase Clp

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Results	in table
8	Activating Compound
69829	AA Sequence
19	Application
3	CAS Registry Number
67	Cloned(Commentary)
16	Cofactor
14	Crystallization (Commentary)
283	Disease/ Diagnostics
4	Expression
36	General Information
6	General Stability
1	IC50 Value
32	Inhibitors
3	Ki Value [mM]
27	KM Value [mM]
36	Localization
7	Metals/Ions
40	Molecular Weight [Da]
25	Natural Substrates/ Products (Substrates)
222	Organism
1471	PDB ID
7	pH Optimum
1	Posttranslational Modification
57	Protein Variants
24	Purification (Commentary)
3	Reaction
16	Reaction Type
171	Reference
8	Source Tissue
5	Specific Activity [micromol/min/mg]
9	Storage Stability
142	Substrates and Products (Substrate)
57	Subunits
182	Synonyms
2	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
17	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.21.92 - Endopeptidase Clp

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

acyldepsipeptide

2 entries

acyldepsipeptides

Mycobacterium tuberculosis

-

ADEP series 2, 3, 4 as well as two other synthesized derivatives, IDR-10001 and IDR-10011, which incorporate N-methylalanine instead of the more rigid homoproline in the depsipeptide core structure. All five compound are active against Mycobacterium tuberculosis, ADEP2 is the most active

717738

-

ATP

Mus musculus

O88696

stimulates proteolytic activity of ClpP in heart mitochondria of muscle creatine kinase mutants

697889

ClpX

Escherichia coli

-

ClpX binding stimulates ClpP cleavage of peptides larger than a few amino acids and enhances ClpP active-site modification. Stimulation requires ATP binding but not hydrolysis by ClpX

717989

-

additional information

3 entries

-

acyldepsipeptide

Escherichia coli

-

allow the protease to degrade folded native proteins in the absence of its cognate chaperones

683473

acyldepsipeptide

Staphylococcus aureus

Q2G036

acyldepsipeptides in addition to opening the axial pore directly stimulate ClpP activity through cooperative binding

732563

additional information

Escherichia coli

-

carbonyl cyanide m-chloro phenylhydrazone and 2,4-dinitrophenol induce the heat-shock-like response, cellular level of the heat shock regulator protein sigma-32 also increases

696989

-

additional information

Mus musculus

O88696

frataxin deficiency causes significant upregulation of both mitochondrial Lon and ClpP proteases in the cardiac mouse model for Friedreich ataxia. ClpP protein level is progressively enhanced, with ca. 3fold, 3.5fold and 4.5fold increases at 5, 7 and 10 weeks of age in muscle creatine kinase mutants, respectively, despite no change in mRNA levels

697889

-

additional information

Synechococcus elongatus

-

ClpP3/R complex stimulates the steady-state ATPase activity of ClpC

698890

-