3.4.21.91: Flavivirin

This is an abbreviated version!
For detailed information about Flavivirin, go to the full flat file.

Reaction

Selective hydrolysis of -Xaa-Xaa-/-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala =

Synonyms

Dengue NS2b-NS3 protease, Dengue NS3 protease, dengue virus non-structural protein 3, dengue virus NS2B-NS3 protease, dengue virus protease, dengue virus serotype 2 protease, DENV NS2B-NS3, DENV-2 NS2B-NS3 protease, DENV2 NS2BNS3pro, DV2 NS2B/NS3pro, flavivirus NS2B-NS3 protease, non-structural protein 3 serine protease, non-structural protein NS2B-NS3 protease, nonstructural protein 3, NS2-3 protease, NS2B-3 proteinase, NS2B-NS3 complex, NS2B-NS3 protease, NS2B-NS3 protease-helicase, NS2B-NS3 proteinase, NS2B-NS3 proteolytic complex, NS2B-NS3 serine protease, NS2B-NS3 serine proteinase, NS2B-NS3(pro)teinase, NS2b-NS3-protease, NS2B-NS3p, NS2B-NS3pro, NS2B/3 protease, NS2B/NS3, NS2B/NS3 complex, NS2B/NS3 protease, NS2B/NS3 protease complex, NS2B/NS3 proteinase, NS2B/NS3 serine protease, NS2B/NS3pro serine protease, NS2B18NS3, NS2BNS3(pro)tease, NS3, NS3 protease, NS3 proteinase, NS3 serine protease, NS3pro, two-component NS2B-NS3 protease, viral serine protease NS2B/NS3, WNV NS2B-NS3, Yellow fever virus (flavivirus) protease, yellow fever virus NS2B-NS3-181 protease, YFV NS2B/NS3 protease, Zika protease, Zika virus NS2B-NS3 protease, ZIKV NS2B/NS3 protease, ZIKV protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.91 Flavivirin

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Results	in table
4	Activating Compound
82	AA Sequence
40	Application
1	CAS Registry Number
50	Cloned(Commentary)
36	Cofactor
26	Crystallization (Commentary)
72	General Information
1	General Stability
168	IC50 Value
509	Inhibitors
46	kcat/KM [mM/s]
188	Ki Value [mM]
155	KM Value [mM]
34	Localization
3	Metals/Ions
8	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
148	Organism
234	PDB ID
21	pH Optimum
10	pH Range
1	Posttranslational Modification
103	Protein Variants
39	Purification (Commentary)
1	Reaction
1	Reaction Type
136	Reference
2	Renatured (Commentary)
1	Specific Activity [micromol/min/mg]
1	Storage Stability
275	Substrates and Products (Substrate)
9	Subunits
151	Synonyms
20	Temperature Optimum [°C]
1	Temperature Range [°C]
149	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.91 - Flavivirin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

ATG16L1 + H2O

?

Zika virus

-

human autophagy-related protein 16-1, high activity

752362

-

-

?

Dengue virus DEN4 polyprotein + H2O

?

Dengue virus

-

involved in processing of downstream nonstructural proteins of the Dengue virus DEN4 polyprotein precursor

29853

-

-

?

eIF4G1 protein + H2O

?

Zika virus

-

human eukaryotic translation initiation factor 4 gamma 1, high activity

752362

-

-

?

flavivirus polyprotein + H2O

?

Yellow fever virus

-

-

654013

-

654013

?

Flavivirus sp. polyproteins + H2O

?

Flavivirus sp.

-

involved in processing of downstream nonstructural proteins of the virus polyprotein

29852

-

-

?

additional information

?

-

2 entries

additional information

?

-

Japanese encephalitis virus

-

interaction of human brain proteins with the Japanese encephalitis virus NS2B-NS3 protease could be involved in the Japanese encephalitis virus induced pathogenesis

667000

-

-

?

additional information

?

-

West Nile virus

-

NS3 alone triggers the apoptotic pathways involving caspases-8 and -3. Activation of caspase-8 is essential to initiate apoptotic signaling in NS3-expressing cells

666999

-

-

?