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3.4.21.9: enteropeptidase

This is an abbreviated version!
For detailed information about enteropeptidase, go to the full flat file.

Word Map on EC 3.4.21.9

Reaction

Activation of trypsinogen by selective cleavage of Lys6-/-Ile bond =

Synonyms

BEK, BEP, bovine enterokinase light chain, bovine enteropeptidase, Chinese bovine enterokinase, Chinese northern yellow bovine enterokinase catalytic subunit, EC 3.4.4.8, EK, EKL, EKL-His6, EKLC, enterokinase, enterokinase light chain, enteropeptidase, enteropeptidase light chain, EP 118-1035, EP-1, EPL, HEK, HEP, human enteropeptidase, L-BEP, L-HEK, L-HEP, native enterokinase, natural enteropeptidase, peptidase, entero-, porcine enterokinase, PRSS7, recombinant bovine enterokinase catalytic subunit protein, recombinant enterokinase light chain, recombinant His-tagged enterokinase light chain, rEKL, rEKL/His, sBEKLC, TMPRSS15

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.9 enteropeptidase

Turnover Number

Turnover Number on EC 3.4.21.9 - enteropeptidase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11.2
A4-mutant trypsinogen
-
37 °C, 100 mM Tris-HCl (pH 8.0), 1 mM CaCl2, 120 nM soybean trypsin inhibitor, 0.13 nM enteropeptidase
-
0.4
angiotensin II
-
in 0.1 M Tris-HCl buffer pH 8.0 at 37°C
28.4
benzoyl-Arg ethyl ester
-
-
262
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
-
0.36 - 1.81
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
4 - 6.9
bovine trypsinogen
-
23.5 - 26.3
formyl-Ala-Phe-Arg-4-nitroanilide
15.4 - 18.2
formyl-Ala-Phe-Lys-4-nitroanilide
0.97 - 17.33
G5DKF(NO2)G
24.9
GD4K 2-naphthylamide
-
pH 8.4, 35°C
64.8
GD4K 7-amido-4-methylcoumarin
-
pH 8.4, 35°C
0.99 - 17.83
GD4KF(NO2)G
0.97 - 16.67
GD4KNfa
42 - 49
GD4R-4-nitroanilide
17.8 - 115
GDDDDK-2-naphthylamide
122 - 148
GDDDDK-4-nitroanilide
520
Gly-Asp-ASp-Asp-Asp-2-naphthylamide
-
-
4.27 - 121
Gly-Asp-Asp-Asp-Asp-Lys-2-naphthylamide
58.38
Gly-L-Asp-L-Asp-L-Asp-L-Asp-L-Lys-2-naphthylamide
at pH 8.0 and 37°C
0.97 - 21.5
glycyl-tetra-L-aspartyl-L-lysine beta-naphthylamide
2.3 - 35.1
human cationic trypsinogen
-
0.07 - 0.49
LTAEEKA
25.17
MLTAEEKAA
-
in 0.1 M Tris-HCl buffer pH 8.0 at 37°C
111
N-alpha-benzyloxycarbonyl-L-lysine thiobenzyl ester
-
37°C, pH 8.0
53
N2-benzoyl-L-Arg ethyl ester
-
-
2.62
PrAD4KP26
-
in 0.1 M Tris-HCl buffer pH 8.0 at 37°C
-
0.3 - 1.38
t-butyloxycarbonyl-E(benzyl ester)-Ala-Arg-7-amido-4-methylcoumarin
129 - 133
thiobenzyl benzyloxy-carbonyl-L-lysinate
108 - 129
thiobenzyl benzyloxycarbonyl-L-lysinate
8.1 - 12
tosyl-Arg methyl ester
12
Tosyl-Lys methyl ester
-
-
0.005 - 6.9
Trypsinogen
15.9
Val-(Ala)2-(Asp)2-Lys-Ile-Val-Gly
-
14.1
Val-(Ala)2-Asp-Ala-Lys-Ile-Val-Gly
-
17
Val-(Ala)3-Asp-Lys-Ile-Val-Gly
-
14.3
Val-(Asp)2-Ala-Asp-Lys-Ile-Val-Gly
-
14.6
Val-(Asp)3-Ala-Lys-Ile-Val-Gly
-
8
Val-(Asp)3-Glu-Lys-Ile-Val-Gly
-
13.6
Val-(Asp)4-Arg-Ile-Val-Gly
-
20
Val-(Asp)4-Lys-Ile-Val-Gly
-
17.8
Val-Ala-(Asp)3-Lys-Ile-Val-Gly
-
23
Val-Ala-Asp-Ala-Asp-Lys-Ile-Val-Gly
-
28.1
Val-Asp-(Ala)2-Asp-Lys-Ile-Val-Gly
-
9.1
Val-Asp-(Ala)3-Lys-Ile-Val-Gly
-
14.7
Val-Asp-Ala-(Asp)2-Lys-Ile-Val-Gly
-
10.3
Val-Asp-Ala-Asp-Ala-Lys-Ile-Val-Gly
-
0.54
WDDKG
-
in 0.1 M Tris-HCl buffer pH 8.0 at 37°C
0.68
WDDRG
-
in 0.1 M Tris-HCl buffer pH 8.0 at 37°C
319 - 354
Z-Lys-SBzl