3.4.21.9: enteropeptidase
This is an abbreviated version!
For detailed information about enteropeptidase, go to the full flat file.
Word Map on EC 3.4.21.9
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3.4.21.9
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trypsinogen
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pancreatic
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duodenal
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thioredoxin
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pancreas
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zymogen
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mucosa
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brush
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juice
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refolding
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chymotrypsin
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trypsin-like
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autoactivation
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ni-nta
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sucrase
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agrin
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lactase
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proenzyme
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trx
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chymotrypsinogen
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polyhistidine
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disaccharidase
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scorpion
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pet-32a
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intraductal
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cerulein
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glycodeoxycholic
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tag-free
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biotechnology
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molecular biology
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synthesis
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analysis
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medicine
- 3.4.21.9
- trypsinogen
- pancreatic
- duodenal
- thioredoxin
- pancreas
- zymogen
- mucosa
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brush
- juice
-
refolding
- chymotrypsin
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trypsin-like
-
autoactivation
-
ni-nta
- sucrase
- agrin
- lactase
- proenzyme
- trx
- chymotrypsinogen
- polyhistidine
- disaccharidase
- scorpion
-
pet-32a
-
intraductal
- cerulein
-
glycodeoxycholic
-
tag-free
- biotechnology
- molecular biology
- synthesis
- analysis
- medicine
Reaction
Activation of trypsinogen by selective cleavage of Lys6-/-Ile bond =
Synonyms
BEK, BEP, bovine enterokinase light chain, bovine enteropeptidase, Chinese bovine enterokinase, Chinese northern yellow bovine enterokinase catalytic subunit, EC 3.4.4.8, EK, EKL, EKL-His6, EKLC, enterokinase, enterokinase light chain, enteropeptidase, enteropeptidase light chain, EP 118-1035, EP-1, EPL, HEK, HEP, human enteropeptidase, L-BEP, L-HEK, L-HEP, native enterokinase, natural enteropeptidase, peptidase, entero-, porcine enterokinase, PRSS7, recombinant bovine enterokinase catalytic subunit protein, recombinant enterokinase light chain, recombinant His-tagged enterokinase light chain, rEKL, rEKL/His, sBEKLC, TMPRSS15
ECTree
3.4.21.9 enteropeptidaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.21.9 - enteropeptidase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
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enterokinase light chain is a serine protease that recognizes Asp-Asp-Asp-Asp-Lys, D4K, sequence and cleaves the C-terminal peptide bond of the lysine residue
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?
Trypsinogen + H2O
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initiates activation of pancreatic hydrolases by cleaving and activating trypsinogen
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?
Trypsinogen + H2O
?
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the enzyme plays a key role in initiating the proteolytic digestion cascade in duodenum by converting trypsinogen to trypsin
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?
Trypsinogen + H2O
?
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enterokinase deficiency is a distinct clinical entity characterized by diarrhea, failure to thrive, hypoproteinemia, and edema. Acquired enterokinase deficiency may occur in some diffuse small bowel diseases. Steatorhea of cellac sprue may be due partly to the fact that deficiency of secretin and cholecystokinin may interfere with the action of enterokinase
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?
Trypsinogen + H2O
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rapid activation of trypsinogen in pancreatic juice. The enzyme has a key permissive role in protein digestion and plays an essential part in the zymogen mechanism that protects the pancreas from self-destruction
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Trypsinogen + H2O
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initiation of digestive enzyme activation by converting trypsinogen into trypsin
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?
trypsinogen + H2O
trypsin
activation by by endoproteolytic cleavage
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?
