3.4.21.76: Myeloblastin
This is an abbreviated version!
For detailed information about Myeloblastin, go to the full flat file.
Word Map on EC 3.4.21.76
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3.4.21.76
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ancas
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myeloperoxidase
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elastase
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antineutrophil
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autoantibody
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anca-associated
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cathepsin
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pr3-anca
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polyangiitis
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autoimmune
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granule
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glomerulonephritis
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mpo-anca
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vasculitides
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remission
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autoantigens
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anti-pr3
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perinuclear
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polymorphonuclear
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cyclophosphamide
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azurophilic
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gpa
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crescent
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anti-mpo
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anca-positive
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lactoferrin
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pauci-immune
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churg-strauss
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granulomatous
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elafin
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vasculitic
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anti-myeloperoxidase
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rituximab
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small-vessel
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antibody-associated
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azurocidin
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anti-proteinase
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neutrophil-derived
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polyarteritis
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antinuclear
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mpo-anca-associated
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ethanol-fixed
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goodpasture
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drug development
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diagnostics
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chapel
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medicine
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analysis
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nsp4
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aspartate-specific
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necrotising
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nodosa
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anti-gbm
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anti-glomerular
- 3.4.21.76
-
ancas
- myeloperoxidase
- elastase
-
antineutrophil
- autoantibody
-
anca-associated
- cathepsin
-
pr3-anca
- polyangiitis
- autoimmune
- granule
- glomerulonephritis
-
mpo-anca
- vasculitides
-
remission
- autoantigens
- anti-pr3
-
perinuclear
-
polymorphonuclear
- cyclophosphamide
-
azurophilic
- gpa
-
crescent
-
anti-mpo
-
anca-positive
- lactoferrin
-
pauci-immune
-
churg-strauss
-
granulomatous
- elafin
-
vasculitic
-
anti-myeloperoxidase
- rituximab
-
small-vessel
-
antibody-associated
-
azurocidin
-
anti-proteinase
-
neutrophil-derived
- polyarteritis
-
antinuclear
-
mpo-anca-associated
-
ethanol-fixed
-
goodpasture
- drug development
- diagnostics
-
chapel
- medicine
- analysis
- nsp4
-
aspartate-specific
-
necrotising
- nodosa
- anti-gbm
-
anti-glomerular
Reaction
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-/- > -Val-/- =
Synonyms
AGP7, C-ANCA antigen, hPR-3, human leukocyte proteinase 3, human PR3, human proteinase 3, Leukocyte proteinase 3, Leukocyte proteinase 4, membrane proteinase 3, membrane-associated proteinase 3, mP3, mPR3, myeloblastin, neutrophil protease PR3, neutrophil proteinase 3, neutrophil serine protease, neutrophilic serine protease proteinase 3, P29, p29b, PMNL proteinase, Pr 3, PR-3, PR3, protease 3, proteinase 3, Proteinase PR-3, Proteinase-3, proteinase3, PRTN3, SAP3, secreted aspartic proteinase 3, surface proteinase 3, Wegener autoantigen, Wegener's autoantigen, Wegener's granulomatosis autoantigen, Xenopus PR3, xPR-3
ECTree
3.4.21.76 MyeloblastinAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.21.76 - Myeloblastin
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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increased PR-3 on the alveolar macrophage surface in usual interstitial pneumonia relative to healthy controls and sarcoidosis subjects
PR3 plasma concentrations are increased in patients with liver steatosis
proteinase 3 is considerably more expressed in bone marrow than in the peripheral blood
additional information
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cell associated PR3 levels are lower than in neutrophils, thus sensitivity of the indirect immunofluorescence test is lower
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blood neutrophils from patients with active Wegeners granulomatosis bear greater amounts of PR3 on their cell membranes than do neutrophils from healthy individuals
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endogenous annexin 1 and PR3 localization in resting and stimulated blood neutrophils
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high molecular weight complexes of unstimulated neutrophils comprise PR3, FcgammaRIIIb, the beta2 integrin CD11b/CD18, the membrane and cytosolic subunits of the NADPH oxidase, p22phox and p47phox/p67phox
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targeting to granules is not dependent on glycosylation, but unglycosylated recombinant PR3 gets secreted preferentially into media supernatants
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neutrophil extracts from vasculitis patients and healthy controls contain comparable amounts of PR3
neutrophil membrane expression of PR3 increases during both activation and apoptosis
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presence of anti-complementary PR3 and anti-PR3 antibodies in human Wegeners granulomatosis sera
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cell associated PR3 levels are lower than in neutrophils, thus sensitivity of the indirect immunofluorescence test is lower
additional information
neutrophil-dereived PR3 is more potent than urinary PR3
additional information
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neutrophil-dereived PR3 is more potent than urinary PR3
additional information
mRNA for PR3 is transcribed in the promyelocyte and promonocyte stages of myeloid differentiation. Present in mastocytes and no-hematopoietic cell
additional information
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mRNA for PR3 is transcribed in the promyelocyte and promonocyte stages of myeloid differentiation. Present in mastocytes and no-hematopoietic cell
additional information
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PR3 antigen is usually present in granulomas and antigen-presenting cells are found in these lesions as well
additional information
proteinase 3 is expressed by myeloid cells and localized within azurophil granules, it is also expressed on the cellular membrane of polymorphonuclear neutrophils (PMN)
additional information
the neutrophil membrane mPR3 is highly induced in patients with sepsis
additional information
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the neutrophil membrane mPR3 is highly induced in patients with sepsis
