3.4.21.76: Myeloblastin
This is an abbreviated version!
For detailed information about Myeloblastin, go to the full flat file.
Word Map on EC 3.4.21.76
-
3.4.21.76
-
ancas
-
myeloperoxidase
-
elastase
-
antineutrophil
-
autoantibody
-
anca-associated
-
cathepsin
-
pr3-anca
-
polyangiitis
-
autoimmune
-
granule
-
glomerulonephritis
-
mpo-anca
-
vasculitides
-
remission
-
autoantigens
-
anti-pr3
-
perinuclear
-
polymorphonuclear
-
cyclophosphamide
-
azurophilic
-
gpa
-
crescent
-
anti-mpo
-
anca-positive
-
lactoferrin
-
pauci-immune
-
churg-strauss
-
granulomatous
-
elafin
-
vasculitic
-
anti-myeloperoxidase
-
rituximab
-
small-vessel
-
antibody-associated
-
azurocidin
-
anti-proteinase
-
neutrophil-derived
-
polyarteritis
-
antinuclear
-
mpo-anca-associated
-
ethanol-fixed
-
goodpasture
-
drug development
-
diagnostics
-
chapel
-
medicine
-
analysis
-
nsp4
-
aspartate-specific
-
necrotising
-
nodosa
-
anti-gbm
-
anti-glomerular
- 3.4.21.76
-
ancas
- myeloperoxidase
- elastase
-
antineutrophil
- autoantibody
-
anca-associated
- cathepsin
-
pr3-anca
- polyangiitis
- autoimmune
- granule
- glomerulonephritis
-
mpo-anca
- vasculitides
-
remission
- autoantigens
- anti-pr3
-
perinuclear
-
polymorphonuclear
- cyclophosphamide
-
azurophilic
- gpa
-
crescent
-
anti-mpo
-
anca-positive
- lactoferrin
-
pauci-immune
-
churg-strauss
-
granulomatous
- elafin
-
vasculitic
-
anti-myeloperoxidase
- rituximab
-
small-vessel
-
antibody-associated
-
azurocidin
-
anti-proteinase
-
neutrophil-derived
- polyarteritis
-
antinuclear
-
mpo-anca-associated
-
ethanol-fixed
-
goodpasture
- drug development
- diagnostics
-
chapel
- medicine
- analysis
- nsp4
-
aspartate-specific
-
necrotising
- nodosa
- anti-gbm
-
anti-glomerular
Reaction
Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-/- > -Val-/- =
Synonyms
AGP7, C-ANCA antigen, hPR-3, human leukocyte proteinase 3, human PR3, human proteinase 3, Leukocyte proteinase 3, Leukocyte proteinase 4, membrane proteinase 3, membrane-associated proteinase 3, mP3, mPR3, myeloblastin, neutrophil protease PR3, neutrophil proteinase 3, neutrophil serine protease, neutrophilic serine protease proteinase 3, P29, p29b, PMNL proteinase, Pr 3, PR-3, PR3, protease 3, proteinase 3, Proteinase PR-3, Proteinase-3, proteinase3, PRTN3, SAP3, secreted aspartic proteinase 3, surface proteinase 3, Wegener autoantigen, Wegener's autoantigen, Wegener's granulomatosis autoantigen, Xenopus PR3, xPR-3
ECTree
3.4.21.76 MyeloblastinAdvanced search results
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Reference on EC 3.4.21.76 - Myeloblastin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kam, C.M.; Kerrigan, J.E.; Dolman, K.M.; Goldschmeding, R.; von dem Borne, A.E.G.K.; Powers, J.C.
Substrate and inhibitor studies on proteinase 3
FEBS Lett.
297
119-123
1992
Homo sapiens
Labbaye, C.; Musette, P.; Cayre, Y.E.
Wegener autoantigen and myeloblastin are encoded by a single mRNA
Proc. Natl. Acad. Sci. USA
88
9253-9256
1991
Homo sapiens
Rao, N.V.; Wehner, N.G.; Marshall, B.C.; Gray, W.R.; Gray, B.H.; Hoidal, J.R.
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties
J. Biol. Chem.
266
9540-9548
1991
Homo sapiens
Brubaker, M.J.; Groutas, W.C.; Hoidal, J.R.; Rao, N.V.
Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters
Biochem. Biophys. Res. Commun.
188
1318-1324
1992
Homo sapiens
Hoidal, J.R.; Rao, N.V.; Gray, B.
Myeloblastin: leukocyte proteinase 3
Methods Enzymol.
244
61-67
1994
Homo sapiens
Dolman, K.M.; van de Wiel, B.A.; Kam, C.M.; Abbink, J.J.; Hack, C.E.; Sonnenberg, A.; Powers, J.C.; van dem Borne, A.E.G.K.; Goldscheding, R.
Determination of proteinase 3-alpha 1-antitrypsin complexes in inflammatory fluids
FEBS Lett.
314
117-121
1992
Homo sapiens
Renesto, P.; Halbwachs-Mecarelli, L.; Nusbaum, P.; Lesavre, P.; Chignard, M.
Proteinase 3. A neutrophil proteinase with activity on platelets
J. Immunol.
152
4612-4617
1994
Homo sapiens
Rao, N.V.; Rao, G.V.; Marshall, B.C.; Hoidal, J.R.
Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G
J. Biol. Chem.
271
2972-2978
1996
Homo sapiens
Dolman, K.M.; van de Wiel, B.A.; Kam, C.M.; Kerrigan, J.E.; Hack, C.E.; van dem Borne, A.E.G.K.; Powers, J.C.; Goldschmeding, R.
Proteinase 3: substrate specificity and possible pathogenetic effect of Wegeners granulomatosis autoantibodies (c-ANCA) by dysregulation of the enzyme
Adv. Exp. Med. Biol.
336
55-60
1993
Homo sapiens
Wiedow, O.; Luedemann, J.; Utecht, B.; Christophers, E.
Inhibition of proteinase 3 activity by peptides derived from human epidermis
Adv. Exp. Med. Biol.
336
61-66
1993
Homo sapiens
Korkmaz, B.; Attucci, S.; Hazouard, E.; Ferrandiere, M.; Jourdan, M.L.; Brillard-Bourdet, M.; Juliano, L.; Gauthier, F.
Discriminating between the activities of human neutrophil elastase and proteinase 3 using serpin-derived fluorogenic substrates
J. Biol. Chem.
277
39074-39081
2002
Homo sapiens
Groutas, W.C.; Ruan, S.; Kuang, R.; Hook, J.B.; Sands, H.
Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032)
Biochem. Biophys. Res. Commun.
233
697-699
1997
Homo sapiens
Groutas, W.C.; Kuang, R.; Ruan, S.; Epp, J.B.; Venkataraman, R.; Truong, T.M.
Potent and specific inhibition of human leukocyte elastase, cathepsin G and proteinase 3 by sulfone derivatives employing the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold
Bioorg. Med. Chem.
6
661-671
1998
Homo sapiens
He, S.; Kuang, R.; Venkataraman, R.; Tu, J.; Truong, T.M.; Chan, H.K.; Groutas, W.C.
Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide
Bioorg. Med. Chem.
8
1713-1717
2000
Homo sapiens
Goldmann, W.H.; Niles, J.L.; Arnaout, M.A.
Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers
Eur. J. Biochem.
261
155-162
1999
Homo sapiens
Witko-Sarsat, V.; Canteloup, S.; Durant, S.; Desdouets, C.; Chabernaud, R.; Lemarchand, P.; Descamps-Latscha, B.
Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation
J. Biol. Chem.
277
47338-47347
2002
Homo sapiens, Rattus norvegicus
Koehl, C.; Knight, C.G.; Bieth, J.G.
Compared action of neutrophil proteinase 3 and elastase on model substrates. Favorable effect of S'-P' interactions on proteinase 3 catalysts
J. Biol. Chem.
278
12609-12612
2003
Homo sapiens
Campbell, E.J.; Campbell, M.A.; Owen, C.A.
Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition
J. Immunol.
165
3366-3374
2000
Homo sapiens
Stummann, L.; Wiik, A.
A simple high yield procedure for purification of human proteinase 3, the main molecular target of cANCA
J. Immunol. Methods
206
35-42
1997
Homo sapiens
Korkmaz, B.; Attucci, S.; Moreau, T.; Godat, E.; Juliano, L.; Gauthier, F.
Design and use of highly specific substrates of neutrophil elastase and proteinase 3
Am. J. Respir. Cell Mol. Biol.
30
801-807
2004
Homo sapiens (P24158), Homo sapiens
Lombard, C.; Bouchu, D.; Wallach, J.; Saulnier, J.
Proteinase 3 hydrolysis of peptides derived from human elastin exon 24
Amino Acids
28
403-408
2005
Homo sapiens (P24158), Homo sapiens
Csernok, E.; Ai, M.; Gross, W.L.; Wicklein, D.; Petersen, A.; Lindner, B.; Lamprecht, P.; Holle, J.U.; Hellmich, B.
Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway
Blood
107
4440-4448
2006
Homo sapiens (P24158), Homo sapiens
Zani, M.L.; Nobar, S.M.; Lacour, S.A.; Lemoine, S.; Boudier, C.; Bieth, J.G.; Moreau, T.
Kinetics of the inhibition of neutrophil proteinases by recombinant elafin and pre-elafin (trappin-2) expressed in Pichia pastoris
Eur. J. Biochem.
271
2370-2378
2004
Homo sapiens (P24158), Homo sapiens
Nobar, S.M.; Zani, M.L.; Boudier, C.; Moreau, T.; Bieth, J.G.
Oxidized elafin and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3
FEBS J.
272
5883-5893
2005
Homo sapiens (P24158)
Wiesner, O.; Litwiller, R.D.; Hummel, A.M.; Viss, M.A.; McDonald, C.J.; Jenne, D.E.; Fass, D.N.; Specks, U.
Differences between human proteinase 3 and neutrophil elastase and their murine homologues are relevant for murine model experiments
FEBS Lett.
579
5305-5312
2005
Homo sapiens (P24158), Homo sapiens, Mus musculus (Q61096), Mus musculus
Hirche, T.O.; Crouch, E.C.; Espinola, M.; Brokelman, T.J.; Mecham, R.P.; DeSilva, N.; Cooley, J.; Remold-O'Donnell, E.; Belaaouaj, A.
Neutrophil serine proteinases inactivate surfactant protein D by cleaving within a conserved subregion of the carbohydrate recognition domain
J. Biol. Chem.
279
27688-27698
2004
Homo sapiens (P24158), Homo sapiens, Mus musculus (Q61096), Mus musculus
Dublet, B.; Ruello, A.; Pederzoli, M.; Hajjar, E.; Courbebaisse, M.; Canteloup, S.; Reuter, N.; Witko-Sarsat, V.
Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line. Molecular analysis of the cleavage site
J. Biol. Chem.
280
30242-30253
2005
Homo sapiens (P24158)
Pederzoli, M.; Kantari, C.; Gausson, V.; Moriceau, S.; Witko-Sarsat, V.
Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils
J. Immunol.
174
6381-6390
2005
Homo sapiens (P24158), Homo sapiens, Rattus norvegicus (Q8K597)
Hajjar, E.; Korkmaz, B.; Gauthier, F.; Brandsdal, B.O.; Witko-Sarsat, V.; Reuter, N.
Inspection of the binding sites of proteinase3 for the design of a highly specific substrate
J. Med. Chem.
49
1248-1260
2006
Homo sapiens (P24158), Homo sapiens
Schreiber, A.; Luft, F.C.; Kettritz, R.
Membrane proteinase 3 expression and ANCA-induced neutrophil activation
Kidney Int.
65
2172-2183
2004
Homo sapiens (P24158)
Pendergraft, W.F.3rd.; Rudolph, E.H.; Falk, R.J.; Jahn, J.E.; Grimmler, M.; Hengst, L.; Jennette, J.C.; Preston, G.A.
Proteinase 3 sidesteps caspases and cleaves p21 Waf1/Cip1/Sdi1 to induce endothelial cell apoptosis
Kidney Int.
65
75-84
2004
Homo sapiens (P24158), Homo sapiens
Novick, D.; Rubinstein, M.; Azam, T.; Rabinkov, A.; Dinarello, C.A.; Kim, S.H.
Proteinase 3 is an IL-32 binding protein
Proc. Natl. Acad. Sci. USA
103
3316-3321
2006
Homo sapiens (P24158), Homo sapiens
Korkmaz, B.; Moreau, T.; Gauthier, F.
Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions
Biochimie
90
227-242
2008
Homo sapiens (P24158), Homo sapiens
Mueller, A.; Voswinkel, J.; Gottschlich, S.; Csernok, E.
Human proteinase 3 (PR3) and its binding molecules: implications for inflammatory and PR3-related autoimmune responses
Ann. N. Y. Acad. Sci.
1109
84-92
2007
Homo sapiens
Kantari, C.; Pederzoli-Ribeil, M.; Amir-Moazami, O.; Gausson-Dorey, V.; Moura, I.C.; Lecomte, M.C.; Benhamou, M.; Witko-Sarsat, V.
Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis
Blood
110
4086-4095
2007
Homo sapiens
Jenne, D.E.; Kuhl, A.
Production and applications of recombinant proteinase 3, Wegeners autoantigen: problems and perspectives
Clin. Nephrol.
66
153-159
2006
Homo sapiens, Mus musculus
Csernok, E.; Moosig, F.; Gross, W.L.
Pathways to ANCA production: From differentiation of dendritic cells by proteinase 3 to B lymphocyte maturation in Wegeners granuloma
Clin. Rev. Allergy Immunol.
34
300-306
2008
Homo sapiens, Mus musculus
Hajjar, E.; Korkmaz, B.; Reuter, N.
Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase
FEBS Lett.
581
5685-5690
2007
Homo sapiens, Mus musculus, Rattus norvegicus
Specks, U.; Fass, D.N.; Finkielman, J.D.; Hummel, A.M.; Viss, M.A.; Litwiller, R.D.; McDonald, C.J.
Functional significance of Asn-linked glycosylation of proteinase 3 for enzymatic activity, processing, targeting, and recognition by anti-neutrophil cytoplasmic antibodies
J. Biochem.
141
101-112
2007
Homo sapiens
Korkmaz, B.; Hajjar, E.; Kalupov, T.; Reuter, N.; Brillard-Bourdet, M.; Moreau, T.; Juliano, L.; Gauthier, F.
Influence of charge distribution at the active site surface on the substrate specificity of human neutrophil protease 3 and elastase. A kinetic and molecular modeling analysis
J. Biol. Chem.
282
1989-1997
2007
Homo sapiens
Vong, L.; DAcquisto, F.; Pederzoli-Ribeil, M.; Lavagno, L.; Flower, R.J.; Witko-Sarsat, V.; Perretti, M.
Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3
J. Biol. Chem.
282
29998-30004
2007
Homo sapiens
Fridlich, R.; David, A.; Aviram, I.
Membrane proteinase 3 and its interactions within microdomains of neutrophil membranes
J. Cell. Biochem.
99
117-125
2006
Homo sapiens
Bauer, S.; Abdgawad, M.; Gunnarsson, L.; Segelmark, M.; Tapper, H.; Hellmark, T.
Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils
J. Leukoc. Biol.
81
458-464
2007
Homo sapiens
Villegas-Mendez, A.; Montes, R.; Ambrose, L.R.; Warrens, A.N.; Laffan, M.; Lane, D.A.
Proteolysis of the endothelial cell protein C receptor by neutrophil proteinase 3
J. Thromb. Haemost.
5
980-988
2007
Homo sapiens
Borelli, C.; Ruge, E.; Schaller, M.; Monod, M.; Korting, H.C.; Huber, R.; Maskos, K.
The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A
Proteins
68
738-748
2007
Candida albicans
Damoiseaux, J.; Daehnrich, C.; Rosemann, A.; Probst, C.; Komorowski, L.; Stegeman, C.A.; Egerer, K.; Hiepe, F.; van Paassen, P.; Stoecker, W.; Schlumberger, W.; Tervaert, J.W.
A novel enzyme-linked immunosorbent assay using a mixture of human native and recombinant proteinase-3 significantly improves the diagnostic potential for antineutrophil cytoplasmic antibody-associated vasculitis
Ann. Rheum. Dis.
68
228-233
2009
Homo sapiens (P24158), Homo sapiens
Armstrong, L.; Godinho, S.I.; Uppington, K.M.; Whittington, H.A.; Millar, A.B.
Tumour necrosis factor-alpha processing in interstitial lung disease: a potential role for exogenous proteinase-3
Clin. Exp. Immunol.
156
336-343
2009
Homo sapiens
Kasuga, A.; Mandai, Y.; Katsuno, T.; Sato, T.; Yamaguchi, T.; Yokosuka, O.
Pulmonary complications resembling Wegeners granulomatosis in ulcerative colitis with elevated proteinase-3 anti-neutrophil cytoplasmic antibody
Intern. Med.
47
1211-1214
2008
Homo sapiens
Wysocka, M.; Lesner, A.; Majkowska, G.; Legowska, A.; Guzow, K.; Rolka, K.; Wiczk, W.
The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region
Anal. Biochem.
399
196-201
2010
Homo sapiens
Wysocka, M.; Lesner, A.; Guzow, K.; Kulczycka, J.; Legowska, A.; Wiczk, W.; Rolka, K.
Highly specific substrates of proteinase 3 containing 3-(2-benzoxazol-5-yl)-l-alanine and their application for detection of this enzyme in human serum
Anal. Chem.
82
3883-3889
2010
Homo sapiens
Hu, N.; Westra, J.; Huitema, M.G.; Bijl, M.; Brouwer, E.; Stegeman, C.A.; Heeringa, P.; Limburg, P.C.; Kallenberg, C.G.
Coexpression of CD177 and membrane proteinase 3 on neutrophils in antineutrophil cytoplasmic autoantibody-associated systemic vasculitis: anti-proteinase 3-mediated neutrophil activation is independent of the role of CD177-expressing neutrophils
Arthritis Rheum.
60
1548-1557
2009
Homo sapiens
Joosten, L.A.; Netea, M.G.; Fantuzzi, G.; Koenders, M.I.; Helsen, M.M.; Sparrer, H.; Pham, C.T.; van der Meer, J.W.; Dinarello, C.A.; van den Berg, W.B.
Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
Arthritis Rheum.
60
3651-3662
2009
Homo sapiens, Mus musculus
Hu, N.; Westra, J.; Kallenberg, C.G.
Membrane-bound proteinase 3 and its receptors: relevance for the pathogenesis of Wegeners Granulomatosis
Autoimmun. Rev.
8
510-514
2009
Homo sapiens
Dou, D.; He, G.; Li, Y.; Lai, Z.; Wei, L.; Alliston, K.R.; Lushington, G.H.; Eichhorn, D.M.; Groutas, W.C.
Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3
Bioorg. Med. Chem.
18
1093-1102
2010
Homo sapiens
Hajjar, E.; Broemstrup, T.; Kantari, C.; Witko-Sarsat, V.; Reuter, N.
Structures of human proteinase 3 and neutrophil elastase - so similar yet so different
FEBS J.
277
2238-2254
2010
Homo sapiens, Mus musculus
Korkmaz, B.; Jaillet, J.; Jourdan, M.L.; Gauthier, A.; Gauthier, F.; Attucci, S.
Catalytic activity and inhibition of Wegener antigen proteinase 3 on the cell surface of human polymorphonuclear neutrophils
J. Biol. Chem.
284
19896-19902
2009
Homo sapiens
Kahn, R.; Hellmark, T.; Leeb-Lundberg, L.M.; Akbari, N.; Todiras, M.; Olofsson, T.; Wieslander, J.; Christensson, A.; Westman, K.; Bader, M.; Mueller-Esterl, W.; Karpman, D.
Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin
J. Immunol.
182
7906-7915
2009
Homo sapiens
Kuhl, A.; Korkmaz, B.; Utecht, B.; Kniepert, A.; Schoenermarck, U.; Specks, U.; Jenne, D.E.
Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis
J. Immunol.
185
387-399
2010
Homo sapiens, Macaca mulatta, Hylobates pileatus, Pan troglodytes verus
Geyer, M.; Kulamarva, G.; Davis, A.
Wegeners Granulomatosis presenting with an abscess in the parotid gland: a case report
J. Med. Case Rep.
3
19
2009
Homo sapiens
Hajjar, E.; Dejaegere, A.; Reuter, N.
Challenges in pKa predictions for proteins: the case of Asp213 in human proteinase 3
J. Phys. Chem. A
113
11783-11792
2009
Homo sapiens
Hua, F.; Wilde, B.; Dolff, S.; Witzke, O.
T-lymphocytes and disease mechanisms in Wegeners granulomatosis
Kidney Blood Press. Res.
32
389-398
2009
Homo sapiens
Piesche, M.; Hildebrandt, Y.; Chapuy, B.; Wulf, G.G.; Truemper, L.; Schroers, R.
Characterization of HLA-DR-restricted T-cell epitopes derived from human proteinase 3
Vaccine
27
4718-4723
2009
Homo sapiens
Abdgawad, M.; Gunnarsson, L.; Bengtsson, A.A.; Geborek, P.; Nilsson, L.; Segelmark, M.; Hellmark, T.
Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression
Clin. Exp. Immunol.
161
89-97
2010
Homo sapiens
Kaellquist, L.; Rosen, H.; Nordenfelt, P.; Calafat, J.; Janssen, H.; Persson, A.M.; Hansson, M.; Olsson, I.
Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells
Exp. Cell Res.
316
3182-3196
2010
Homo sapiens
Kantari, C.; Millet, A.; Gabillet, J.; Hajjar, E.; Broemstrup, T.; Pluta, P.; Reuter, N.; Witko-Sarsat, V.
Molecular analysis of the membrane insertion domain of proteinase 3, the Wegeners autoantigen, in RBL cells: implication for its pathogenic activity
J. Leukoc. Biol.
90
941-950
2011
Homo sapiens
Kim, Y.C.; Shin, J.E.; Lee, S.H.; Chung, W.J.; Lee, Y.S.; Choi, B.K.; Choi, Y.
Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils
Mol. Immunol.
48
1966-1974
2011
Homo sapiens
Broemstrup, T.; Reuter, N.
How does proteinase 3 interact with lipid bilayers?
Phys. Chem. Chem. Phys.
12
7487-7496
2010
Homo sapiens (P24158)
Relle, M.; Thomaidis, T.; Galle, P.R.; Schwarting, A.
Comparative aspects of murine proteinase 3
Rheumatol. Int.
31
1105-1111
2011
Mus musculus (Q61096), Mus musculus
Hwang, T.L.; Wang, W.H.; Wang, T.Y.; Yu, H.P.; Hsieh, P.W.
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3
Bioorg. Med. Chem.
23
1123-1134
2015
Homo sapiens (P24158), Homo sapiens
Hinkofer, L.C.; Hummel, A.M.; Stone, J.H.; Hoffman, G.S.; Merkel, P.A.; Spiera, E.R.; St Clair, W.; McCune, J.W.; Davis, J.C.; Specks, U.; Jenne, D.E.
Allosteric modulation of proteinase 3 activity by anti-neutrophil cytoplasmic antibodies in granulomatosis with polyangiitis
J. Autoimmun.
59
43-52
2015
Homo sapiens (P24158), Homo sapiens
Hinkofer, L.C.; Seidel, S.A.; Korkmaz, B.; Silva, F.; Hummel, A.M.; Braun, D.; Jenne, D.E.; Specks, U.
A monoclonal antibody (MCPR3-7) interfering with the activity of proteinase 3 by an allosteric mechanism
J. Biol. Chem.
288
26635-26648
2013
Homo sapiens (P24158)
Budnjo, A.; Narawane, S.; Grauffel, C.; Schillinger, A.S.; Fossen, T.; Reuter, N.; Haug, B.E.
Reversible ketomethylene-based inhibitors of human neutrophil proteinase 3
J. Med. Chem.
57
9396-9408
2014
Homo sapiens (P24158), Homo sapiens
Grzywa, R.; Lesner, A.; Korkmaz, B.; Sienczyk, M.
Proteinase 3 phosphonic inhibitors
Biochimie
166
142-149
2019
Homo sapiens (P24158)
Popow-Stellmaszyk, J.; Bajorowicz, B.; Malankowska, A.; Wysocka, M.; Klimczuk, T.; Zaleska-Medynska, A.; Lesner, A.
Design, synthesis, and enzymatic evaluation of novel ZnO quantum Dot-based assay for detection of proteinase 3 activity
Bioconjug. Chem.
29
1576-1583
2018
Homo sapiens (P24158)
Hwang, T.; Wang, W.; Wang, T.; Yu, H.; Hsieh, P.
Synthesis and pharmacological characterization of 2-aminobenzaldehyde oxime analogs as dual inhibitors of neutrophil elastase and proteinase 3
Bioorg. Med. Chem.
23
1123-1134
2015
Homo sapiens (P24158), Homo sapiens
Fu, Z.; Thorpe, M.; Akula, S.; Chahal, G.; Hellman, L.T.
Extended cleavage specificity of human neutrophil elastase, human proteinase 3, and their distant ortholog clawed frog PR3 - three elastases with similar primary but different extended specificities and stability
Front. Immunol.
9
2387
2018
Homo sapiens (P24158), Homo sapiens, Xenopus laevis
Chen, Y.; Liu, Z.; Pan, T.; Chen, E.; Mao, E.; Chen, Y.; Tan, R.; Wang, X.; Tian, R.; Liu, J.; Qu, H.
JMJD3 is involved in neutrophil membrane proteinase 3 overexpression during the hyperinflammatory response in early sepsis
Int. Immunopharmacol.
59
40-46
2018
Homo sapiens (P24158), Homo sapiens
Martin, K.R.; Kantari-Mimoun, C.; Yin, M.; Pederzoli-Ribeil, M.; Angelot-Delettre, F.; Ceroi, A.; Grauffel, C.; Benhamou, M.; Reuter, N.; Saas, P.; Frachet, P.; Boulanger, C.M.; Witko-Sarsat, V.
Proteinase 3 is a phosphatidylserine-binding protein that affects the production and function of microvesicles
J. Biol. Chem.
291
10476-10489
2016
Homo sapiens (P24158), Homo sapiens
Yang, T.H.; St John, L.S.; Garber, H.R.; Kerros, C.; Ruisaard, K.E.; Clise-Dwyer, K.; Alatrash, G.; Ma, Q.; Molldrem, J.J.
Membrane-associated proteinase 3 on granulocytes and acute myeloid leukemia inhibits T cell proliferation
J. Immunol.
201
1389-1399
2018
Homo sapiens (P24158)
Guarino, C.; Gruba, N.; Grzywa, R.; Dyguda-Kazimierowicz, E.; Hamon, Y.; Legowska, M.; Skorenski, M.; Dallet-Choisy, S.; Marchand-Adam, S.; Kellenberger, C.; Jenne, D.E.; Sienczyk, M.; Lesner, A.; Gauthier, F.; Korkmaz, B.
Exploiting the S4-S5 specificity of human neutrophil proteinase 3 to improve the potency of peptidyl di(chlorophenyl)-phosphonate ester inhibitors a kinetic and molecular modeling analysis
J. Med. Chem.
61
1858-1870
2018
Homo sapiens (P24158), Homo sapiens
Mirea, A.M.; Toonen, E.J.M.; van den Munckhof, I.; Munsterman, I.D.; Tjwa, E.T.T.L.; Jaeger, M.; Oosting, M.; Schraa, K.; Rutten, J.H.W.; van der Graaf, M.; Riksen, N.P.; de Graaf, J.; Netea, M.G.; Tack, C.J.; Chavakis, T.; Joosten, L.A.B.
Increased proteinase 3 and neutrophil elastase plasma concentrations are associated with non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes
Mol. Med.
25
16
2019
Homo sapiens (P24158), Homo sapiens
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