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3.4.21.76: Myeloblastin

This is an abbreviated version!
For detailed information about Myeloblastin, go to the full flat file.

Word Map on EC 3.4.21.76

Reaction

Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala-/- > -Val-/- =

Synonyms

AGP7, C-ANCA antigen, hPR-3, human leukocyte proteinase 3, human PR3, human proteinase 3, Leukocyte proteinase 3, Leukocyte proteinase 4, membrane proteinase 3, membrane-associated proteinase 3, mP3, mPR3, myeloblastin, neutrophil protease PR3, neutrophil proteinase 3, neutrophil serine protease, neutrophilic serine protease proteinase 3, P29, p29b, PMNL proteinase, Pr 3, PR-3, PR3, protease 3, proteinase 3, Proteinase PR-3, Proteinase-3, proteinase3, PRTN3, SAP3, secreted aspartic proteinase 3, surface proteinase 3, Wegener autoantigen, Wegener's autoantigen, Wegener's granulomatosis autoantigen, Xenopus PR3, xPR-3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.76 Myeloblastin

KM Value

KM Value on EC 3.4.21.76 - Myeloblastin

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0174
2-aminobenzoyl-Tyr-Tyr-aminobutyl-(5-amino-2-nitrobenzoyl)-Gln-NH2
pH and temperature not specified in the publication
0.0314
2-aminobenzoyl-Tyr-Tyr-aminobutyl-(5-amino-2-nitrobenzoyl)-NH2
pH and temperature not specified in the publication
0.0032
2-aminobenzoyl-Tyr-Tyr-aminobutyl-Asn-Glu-Pro-Tyr(3-NO2)-NH2
pH and temperature not specified in the publication
6.5
2-aminobenzoyl-VADCADQ-EDDnp
-
-
12.3
2-aminobenzoyl-VADCAQ-EDDnp
-
-
0.0123
2-aminobenzoyl-Val-Ala-Asp-Cys-Ala-Gln-N-(2,4-dinitrophenyl)-ethylenediamine
pH and temperature not specified in the publication
0.0033
2-aminobenzoyl-Val-Ala-Asp-Cys-Arg-Asp-Arg-Gln-N-(2,4-dinitrophenyl)-ethylenediamine
pH and temperature not specified in the publication
0.0011
2-aminobenzoyl-Val-Ala-Asp-Nva-Ala-Asp-Tyr-Gln-N-(2,4-dinitrophenyl)-ethylenediamine
pH and temperature not specified in the publication
0.0314
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzamide)
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.1731
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Ala-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0642
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Arg-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0251
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Asn-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0281
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Asp-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0174
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Gln-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0253
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Glu-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.1242
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Gly-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0357
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-His-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.2763
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Ile-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.2436
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Leu-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0729
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Lys-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
1.126
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Phe-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.1823
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Pro-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0278
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Ser-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.0321
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Thr-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
1.274
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Trp-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.9823
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Tyr-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
0.3124
Abz-Tyr-Tyr-Abu-(5-amino-2-nitrobenzoyl)-Val-NH2
-
in 0.1 M Tris-HCl buffer, pH 7.5, with 500 mM NaCl at 25°C
3.1
Abz-VADCADRQ-EDDnp
-
-
0.0065
Abz-VADCADY(NO2)
37°C, pH 7.4, 150 mM NaCl
12
Abz-VADCDDRQ-EDDnp
-
-
3.3
Abz-VADCRDRQ-EDDnp
-
-
2.7
Ac-Ala-Ala-Pro-Ala-p-nitroanilide
-
pH 7.4, 25°C
2.8
Ac-Ala-Ala-Pro-Val-p-nitroanilide
-
pH 7.4, 25°C
2
Boc-Ala-Ala-Pro-Ala-p-nitroanilide
-
pH 7.4, 25°C
1.1 - 1.2
MeOSuc-AAPV-4-nitroanilide
0.61 - 1.5
MeOSuc-AIPM-4-nitroanilide
0.47
MeOSuc-Ala-Ala-Pro-Val-p-nitroanilide
-
pH 7.4, 25°C
0.14
MeOSuc-Lys(2-picolinoyl)-Ala-Pro-Val-p-nitroanilide
-
pH 7.4, 25°C
0.1
MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Ala-p-nitroanilide
-
pH 7.4, 25°C
0.013
MeOSuc-Lys(2-picolinoyl)-Tyr-Asp-Val-p-nitroanilide
-
pH 7.4, 25°C
0.05
O-methyl-succinyl-Ala-Ala-Pro-Ala-S-benzyl ester
pH and temperature not specified in the publication
0.27
O-methyl-succinyl-Ala-Ala-Pro-Val-4-nitroanilide
pH and temperature not specified in the publication
0.61
Suc-AAA-4-nitroanilide
52 mM NaCl, 0.5% Triton X-100 (w/v), 10% dimethylformamide (v/v), pH 8.0
3.5
Suc-AAPL-4-nitroanilide
52 mM NaCl, 0.5% Triton X-100 (w/v), 10% dimethylformamide (v/v), pH 8.0
2.5 - 3.7
Suc-AAPV-4-nitroanilide
0.62
Suc-Ala-Ala-Asp-Val-p-nitroanilide
-
pH 7.4, 25°C
0.97
Suc-Ala-Ala-Glu-Val-p-nitroanilide
-
pH 7.4, 25°C
0.38
Suc-Ala-Ala-Pro-2-aminobutyric acid-p-nitroanilide
-
pH 7.4, 25°C
1.9
Suc-Ala-Ala-Pro-Ala-p-nitroanilide
-
pH 7.4, 25°C
0.64
Suc-Ala-Ala-Pro-Ile-p-nitroanilide
-
pH 7.4, 25°C
0.5
Suc-Ala-Ala-Pro-Nva-p-nitroanilide
-
pH 7.4, 25°C
0.6
Suc-Ala-Ala-Pro-Val-p-nitroanilide
-
pH 7.4, 25°C
0.17
Suc-Ala-Tyr-Leu-Val-p-nitroanilide
-
pH 7.4, 25°C
0.9
Suc-Leu-Val-Glu-Ala-p-nitroanilide
-
pH 7.4, 25°C
0.148
succinyl-Ala-Ala-norvaline-thiobenzyl ester
-
-
0.192
succinyl-Ala-Ala-Nva-S-benzyl ester
pH and temperature not specified in the publication
0.106
tert-butyloxycarbonyl-Ala-Ala-Ala-thiobenzyl ester
-
-
0.031
tert-butyloxycarbonyl-Ala-Ala-Ile-thiobenzyl ester
-
-
0.061
tert-butyloxycarbonyl-Ala-Ala-Met-thiobenzyl ester
-
-
0.063
tert-butyloxycarbonyl-Ala-Ala-norvaline-thiobenzyl ester
-
-
0.063
tert-butyloxycarbonyl-Ala-Ala-Nva-S-benzyl ester
pH and temperature not specified in the publication
0.028
tert-butyloxycarbonyl-Ala-Ala-Val-S-benzyl ester
pH and temperature not specified in the publication
0.028
tert-butyloxycarbonyl-Ala-Ala-Val-thiobenzyl ester
-
-
0.66
tert-butyloxycarbonyl-Ala-O-4-nitrophenyl ester
pH and temperature not specified in the publication
additional information
additional information
-
Km values of peptidyl thiobenzyl esters
-