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3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Word Map on EC 3.4.21.75

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.75 Furin

Turnover Number

Turnover Number on EC 3.4.21.75 - Furin

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
29.3
2-Aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH
-
-
29.6 - 30.3
Abz-GIRRKRSVSHQ-N-(2,4-dinitrophenyl)ethylenediamine
3.6 - 4.2
Abz-GRRTRREAIVQ-N-(2,4-dinitrophenyl)ethylenediamine
28.9 - 39.5
Abz-HHRQRRSVSIQ-N-(2,4-dinitrophenyl)ethylenediamine
6.3 - 6.9
Abz-HKREKRQAKHQ-N-(2,4-dinitrophenyl)ethylenediamine
7.6 - 12.2
Abz-HRREKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
9.2 - 14.9
Abz-HRRQKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
0.6 - 3.1
Abz-KIRRRRDVVDQ-N-(2,4-dinitrophenyl)ethylenediamine
0.61 - 6.7
Abz-LKRRRRDTQQQ-N-(2,4-dinitrophenyl)ethylenediamine
2 - 3.5
Abz-NLRRRRDLVDQ-N-(2,4-dinitrophenyl)ethylenediamine
2.6 - 12.3
Abz-RERRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
8.4 - 11.3
Abz-RKRSRRQVNTQ-N-(2,4-dinitrophenyl)ethylenediamine
5.3 - 8.7
Abz-RRRAKRSPKHQ-N-(2,4-dinitrophenyl)ethylenediamine
12.2 - 14.6
Abz-RRRDKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
5
Abz-RRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
-
pH 7.0, 37°C, presence of Mg2+
2.4 - 6.7
Abz-RRRKKRGLSGQ-N-(2,4-dinitrophenyl)ethylenediamine
1 - 7.6
Abz-RRRKKRSLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
10.5 - 18.3
Abz-SKRSRRSVSVQ-N-(2,4-dinitrophenyl)ethylenediamine
0.21 - 2.4
Abz-SRRHKRFAGVQ-N-(2,4-dinitrophenyl)ethylenediamine
9.2 - 9.9
Abz-SRRKRRDVTPQ-N-(2,4-dinitrophenyl)ethylenediamine
10 - 11.1
Abz-SRRKRRSASTQ-N-(2,4-dinitrophenyl)ethylenediamine
5.6 - 7.1
Abz-SSRHRRALDTQ-N-(2,4-dinitrophenyl)ethylenediamine
16.4 - 19.8
Abz-TRRFRRSITEQ-N-(2,4-dinitrophenyl)ethylenediamine
0.000934
Acetyl-Arg-Glu-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.02
Acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.0507
Acetyl-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide
-
-
0.00111
Acetyl-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.0403
Acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.00159
Acetyl-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
50
acetyl-norleucine-YKR-7-amido-4-methylcoumarin
-
pH 7.0, 37°C
0.00088
Acetyl-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.7
acetyl-RVRR-4-methylcoumarin 7-amide
-
pH 7.0, 37°C
0.00135
acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-7-amido-4-methylcoumarin
-
-
-
250
AcRARYKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
193
AcRYKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
200
AcRYRFKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
21
Boc-RVRR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
0.003
Boc-RVRR-7-amido-4-methylcoumarin
-
3 - 3.6
hBMP-2 precursor protein
-
3.6 - 5.6
hBMP-4 precursor protein
-
0.008
pERKTR-7-amido-4-methylcoumarin
-
5.5
pro-hADAM-15 protein
-
pH 7.0, 37°C
-
4.5
pro-hADAM-TS 4 protein
-
pH 7.0, 37°C
-
40
pro-hADAM-TS 6 protein
-
pH 7.0, 37°C
-
1
pro-hADAMTS-17 protein, pro-hADAMTS-23 protein
-
pH 7.0, 37°C
-
1.5
pro-hTGF-beta1 protein
-
pH 7.0, 37°C
-
3.4
pro-hTGF-beta2 protein
-
pH 7.0, 37°C
-
8.4
pro-hTGF-beta3 protein
-
pH 7.0, 37°C
-
1.2
pro-hTGF-beta4 protein
-
pH 7.0, 37°C
-
2.4
pro-MT-MMP 1 protein
-
pH 7.0, 37°C
-
1.3
pro-MT-MMP 11 protein
-
pH 7.0, 37°C
-
0.5
pro-MT-MMP 3 protein
-
pH 7.0, 37°C
-
5.5
pro-MT-MMP 4 protein
-
pH 7.0, 37°C
-
0.84
pro-MT-MMP 6 protein
-
pH 7.0, 37°C
-
12.2
proaerolysin
-
pH 7.0, 37°C
-
11
protective antigen
-
(-Arg-Lys-Lys-Arg-Ser-Thr-Ser-Ala-Gly-)
-
0.54
Pseudomonas toxin
-
pH 7.0, 37°C
-
16
Shiga toxin
-
pH 7.0, 37°C
-
0.192
tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide
-
-
additional information
additional information
-