3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.75 Furin

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
13	Activating Compound
214	AA Sequence
34	Application
1	CAS Registry Number
66	Cloned(Commentary)
9	Crystallization (Commentary)
2715	Disease/ Diagnostics
9	Expression
83	General Information
1	General Stability
36	IC50 Value
400	Inhibitors
65	kcat/KM [mM/s]
181	Ki Value [mM]
99	KM Value [mM]
65	Localization
35	Metals/Ions
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
506	Organism
60	PDB ID
25	pH Optimum
9	pH Range
3	pH Stability
4	Posttranslational Modification
48	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
188	Reference
136	Source Tissue
8	Specific Activity [micromol/min/mg]
7	Storage Stability
351	Substrates and Products (Substrate)
5	Subunits
119	Synonyms
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
85	Turnover Number [1/s]

Storage Stability

print visible entries

print all entries

Storage Stability on EC 3.4.21.75 - Furin

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Storage Stability Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-10°C, 10% glycerol, 90% loss of activity after 1 week

Mus musculus

-

29704

-20°C, 5 mg/ml bovine serum albumin, less than 5% loss of activity after 2 months

Mus musculus

-

29687

-70°C, 26% loss of activity of furin mutant hFUR713t, 21% loss of activity of soluble furin after 3 weeks, optimal conditions of conservation are at 50% glycerol

Homo sapiens

-

29696

-80°C, 10% glycerol, no detectable loss of activity over 6 months

Mus musculus

-

652060

-80°C, 5-20% loss of activity after 2 weeks

Mus musculus

-

29687

-80°C, Tris-HCl buffer, pH 8.0, 50% glycerol

Trichoplusia ni

Q5DNW1

682710

4°C, 5 mg/ml bovine serum albumin, 0.02% NaN3, less than 5% loss of activity after 2 months

Mus musculus

-

29687