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3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Word Map on EC 3.4.21.75

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.75 Furin

KM Value

KM Value on EC 3.4.21.75 - Furin

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
(2-Aminobenzoyl)-Lys-Glu-Arg-Ser-Lys-Arg-Ser-Ala-Leu-Arg-Asp-(3-nitro)Tyr-Ala
-
-
0.0038
2-Aminobenzoyl-Arg-Val-Lys-Arg-Gly-Leu-Ala-Tyr(NO2)-Asp-OH
-
-
0.00039 - 0.00042
Abz-GIRRKRSVSHQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00021 - 0.0012
Abz-GRRTRREAIVQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0003 - 0.0032
Abz-HHRQRRSVSIQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00038 - 0.0027
Abz-HKREKRQAKHQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0002 - 0.00022
Abz-HRREKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00028 - 0.00037
Abz-HRRQKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00005 - 0.0001
Abz-KIRRRRDVVDQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00028 - 0.0052
Abz-LKRRRRDTQQQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00033 - 0.0014
Abz-NLRRRRDLVDQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0001
Abz-RERRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0002 - 0.0065
Abz-RKRSRRQVNTQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0012 - 0.0122
Abz-RRRAKRSPKHQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00039 - 0.00041
Abz-RRRDKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0155
Abz-RRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00022
Abz-RRRKKRGLSGQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00023
Abz-RRRKKRSLFGQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00041 - 0.00049
Abz-SKRSRRSVSVQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00007
Abz-SRRHKRFAGVQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00015 - 0.00045
Abz-SRRKRRDVTPQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00014 - 0.005
Abz-SRRKRRSASTQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00086 - 0.00416
Abz-SSRHRRALDTQ-N-(2,4-dinitrophenyl)ethylenediamine
0.00053
Abz-TRRFRRSITEQ-N-(2,4-dinitrophenyl)ethylenediamine
0.0123
Ac-Arg-Val-Arg-Arg-4-nitroanilide
-
-
0.016
Acetyl-Arg-Glu-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.008
Acetyl-Arg-Lys-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.345
Acetyl-Arg-Phe-Ala-Arg-4-methylcoumarin 7-amide
-
-
0.0015
Acetyl-Arg-Pro-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.005
Acetyl-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.106
Acetyl-Lys-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.001
acetyl-norleucineYKR-7-amido-4-methylcoumarin
-
pH 7.0, 37°C
-
0.028
Acetyl-Orn-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.00194
acetyl-RVRR-4-methylcoumarin 7-amide
-
pH 7.0, 37°C
0.0071
Acetyl-Tyr-Glu-Lys-Glu-Arg-Ser-Lys-Arg-4-methylcoumarin 7-amide
-
-
0.0009
AcRARYKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
0.0008
AcRYKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
0.0006
AcRYRFKR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
0.019
Boc-RVRR-4-methylcoumarin-7-amide
-
pH 7.0, 37°C
0.01
Boc-RVRR-7-amido-4-methyl-coumarin
-
-
0.029
Boc-RVRR-7-amido-4-methylcoumarin
-
0.035
DSSARIRRNAKG
-
pH 7.0, 37°C
0.0059
Glu-Arg-Thr-Lys-Arg-(7-methylcoumarin-4-yl)acetate
-
-
0.00007 - 0.0013
hBMP-2 precursor protein
-
0.0014 - 0.0015
hBMP-4 precursor protein
-
0.00124
pERKTR-7-amido-4-methylcoumarin
-
0.005
pGlu-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide
-
-
0.0002
pro-hADAM-15 protein
-
pH 7.0, 37°C
-
0.00055
pro-hADAM-TS 4 protein
-
pH 7.0, 37°C
-
0.0004
pro-hADAM-TS 6 protein
-
pH 7.0, 37°C
-
0.0091
pro-hADAMTS-17 protein
-
pH 7.0, 37°C
-
0.0067
pro-hADAMTS-23 protein
-
pH 7.0, 37°C
-
0.0001
pro-hTGF-best1 protein, pro-hTGF-beta2 protein
-
pH 7.0, 37°C
-
0.00014
pro-hTGF-beta3 protein
-
pH 7.0, 37°C
-
0.0022
pro-hTGF-beta4 protein
-
pH 7.0, 37°C
-
0.00015
pro-MT-MMP 1 protein
-
pH 7.0, 37°C
-
0.00011
pro-MT-MMP 11 protein, pro-MT-MMP 3 protein
-
pH 7.0, 37°C
-
0.00045
pro-MT-MMP 4 protein
-
pH 7.0, 37°C
-
0.00037
pro-MT-MMP 6 protein
-
pH 7.0, 37°C
-
0.00064
proaerolysin
-
pH 7.0, 37°C
-
0.002
protective antigen
-
(-Arg-Lys-Lys-Arg-Ser-Thr-Ser-Ala-Gly-)
-
0.0118
Pseudomonas toxin
-
pH 7.0, 37°C
-
0.0032
Pyr-Arg-Thr-Lys-Arg-4-methylcoumaryl-7-amide
-
pH 7.5, 37°C
0.0026
Shiga toxin
-
pH 7.0, 37°C
-
0.01517
t-butyloxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarin
-
-
0.0156
tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide
-
-
0.000036 - 0.000122
viral precursor protein E3E2
-
additional information
additional information
-