3.4.21.75: Furin

This is an abbreviated version!
For detailed information about Furin, go to the full flat file.

Reaction

Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg-/- bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors =

Synonyms

Bfurin, Dfurin1, Dibasic processing enzyme, FUR, furin, furin A, furin B, furin convertase, furin protease, furin-like pro-protein convertase, furin-like prohormone convertase, furin-like proprotein convertase, furin-like protease, furin-like proteinase, FurinA, furinase, hfurin, KPC-1, More, PACE, Paired basic amino acid cleaving enzyme, Paired basic amino acid converting enzyme, Paired basic amino acid residue cleaving enzyme, PC1, PC1/3, PC2, PCSK3, proconvertase, prohormone convertase, prohormone convertase 1, prohormone convertase 2, Proprotein convertase, proprotein convertase subtilisin/kexin 3, proprotein convertase subtilisin/kexin type 3, proprotein convertase subtilisin/kexin type3, Serine proteinase PACE, Sfurin, sheddase, SPC3, subtilisin-like proprotein convertase, subtilisin-like protein convertase, Trans golgi network protease furin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.75 Furin

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Results	in table
13	Activating Compound
214	AA Sequence
34	Application
1	CAS Registry Number
66	Cloned(Commentary)
9	Crystallization (Commentary)
2715	Disease/ Diagnostics
9	Expression
83	General Information
1	General Stability
36	IC50 Value
400	Inhibitors
65	kcat/KM [mM/s]
181	Ki Value [mM]
99	KM Value [mM]
65	Localization
35	Metals/Ions
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
506	Organism
60	PDB ID
25	pH Optimum
9	pH Range
3	pH Stability
4	Posttranslational Modification
48	Protein Variants
26	Purification (Commentary)
1	Reaction
1	Reaction Type
188	Reference
136	Source Tissue
8	Specific Activity [micromol/min/mg]
7	Storage Stability
351	Substrates and Products (Substrate)
5	Subunits
119	Synonyms
15	Temperature Optimum [°C]
3	Temperature Stability [°C]
85	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.4.21.75 - Furin

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

70550 - 77100

Abz-GIRRKRSVSHQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

3085 - 20190

Abz-GRRTRREAIVQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

9031 - 116100

Abz-HHRQRRSVSIQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

2354 - 17730

Abz-HKREKRQAKHQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

38300 - 55640

Abz-HRREKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

32430 - 40270

Abz-HRRQKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

6000 - 53450

Abz-KIRRRRDVVDQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1303 - 2184

Abz-LKRRRRDTQQQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1470 - 10610

Abz-NLRRRRDLVDQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1555 - 123000

Abz-RERRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1291 - 56300

Abz-RKRSRRQVNTQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

710 - 4383

Abz-RRRAKRSPKHQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

29660 - 37510

Abz-RRRDKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

322

Abz-RRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

797 - 30500

Abz-RRRKKRGLSGQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

606 - 33040

Abz-RRRKKRSLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

25360 - 37350

Abz-SKRSRRSVSVQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

559 - 33860

Abz-SRRHKRFAGVQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

20470 - 66000

Abz-SRRKRRDVTPQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1992 - 76230

Abz-SRRKRRSASTQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

1707 - 6488

Abz-SSRHRRALDTQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

28360 - 37360

Abz-TRRFRRSITEQ-N-(2,4-dinitrophenyl)ethylenediamine

2 entries

361

acetyl-RVRR-4-methylcoumarin 7-amide

Homo sapiens

-

pH 7.0, 37°C

707275

2331 - 50710

hBMP-2 precursor protein

2 entries

-

2649 - 3700

hBMP-4 precursor protein

2 entries

-

27600

pro-hADAM-15 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

8127

pro-hADAM-TS 4 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

100000

pro-hADAM-TS 6 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

109

pro-hADAMTS-17 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

143

pro-hADAMTS-23 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

14700

pro-hTGF-beta1 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

34200

pro-hTGF-beta2 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

60140

pro-hTGF-beta3 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

534

pro-hTGF-beta4 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

15800

pro-MT-MMP 1 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

11450

pro-MT-MMP 11 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

4545

pro-MT-MMP 3 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

12670

pro-MT-MMP 4 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

2240

pro-MT-MMP 6 protein

Homo sapiens

-

pH 7.0, 37°C

707275

-

20670

proaerolysin

Homo sapiens

-

pH 7.0, 37°C

707275

-

45

Pseudomonas toxin

Homo sapiens

-

pH 7.0, 37°C

707275

-

6134

Shiga toxin

Homo sapiens

-

pH 7.0, 37°C

707275

-

70550

Abz-GIRRKRSVSHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

77100

Abz-GIRRKRSVSHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

3085

Abz-GRRTRREAIVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

20190

Abz-GRRTRREAIVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

9031

Abz-HHRQRRSVSIQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

116100

Abz-HHRQRRSVSIQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

2354

Abz-HKREKRQAKHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

17730

Abz-HKREKRQAKHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

38300

Abz-HRREKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

55640

Abz-HRREKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

32430

Abz-HRRQKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

40270

Abz-HRRQKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

6000

Abz-KIRRRRDVVDQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

53450

Abz-KIRRRRDVVDQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

1303

Abz-LKRRRRDTQQQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

2184

Abz-LKRRRRDTQQQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

1470

Abz-NLRRRRDLVDQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

10610

Abz-NLRRRRDLVDQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

1555

Abz-RERRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

123000

Abz-RERRRKKRGLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

1291

Abz-RKRSRRQVNTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

56300

Abz-RKRSRRQVNTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

710

Abz-RRRAKRSPKHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

4383

Abz-RRRAKRSPKHQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

29660

Abz-RRRDKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

37510

Abz-RRRDKRSVALQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

797

Abz-RRRKKRGLSGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

30500

Abz-RRRKKRGLSGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

606

Abz-RRRKKRSLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

33040

Abz-RRRKKRSLFGQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

25360

Abz-SKRSRRSVSVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

37350

Abz-SKRSRRSVSVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

559

Abz-SRRHKRFAGVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

33860

Abz-SRRHKRFAGVQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

20470

Abz-SRRKRRDVTPQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

66000

Abz-SRRKRRDVTPQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

1992

Abz-SRRKRRSASTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

76230

Abz-SRRKRRSASTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

1707

Abz-SSRHRRALDTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

6488

Abz-SSRHRRALDTQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

28360

Abz-TRRFRRSITEQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, absence of Mg2+

717306

37360

Abz-TRRFRRSITEQ-N-(2,4-dinitrophenyl)ethylenediamine

Homo sapiens

-

pH 7.0, 37°C, presence of Mg2+

717306

2331

hBMP-2 precursor protein

Homo sapiens

-

second cleavage site, pH 7.0, 37°C

707275

-

50710

hBMP-2 precursor protein

Homo sapiens

-

first cleavage site, pH 7.0, 37°C

707275

-

2649

hBMP-4 precursor protein

Homo sapiens

-

second cleavage site, pH 7.0, 37°C

707275

-

3700

hBMP-4 precursor protein

Homo sapiens

-

first cleavage site, pH 7.0, 37°C

707275

-