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3.4.21.74: venombin A

This is an abbreviated version!
For detailed information about venombin A, go to the full flat file.

Word Map on EC 3.4.21.74

Reaction

Selective cleavage of Arg-/- bond in fibrinogen, to form fibrin, and release fibrinopeptide A. The specificity of further degradation of fibrinogen varies with species origin of the enzyme =

Synonyms

AaV-SP-II, albofibrase1, alpha fibrinogenase, alpha-Fibrinogenase, Ancrod, Batroxobin, beta-fibrinogenase, Bhalternin, bothrombin, Bothrops atrox serine proteinase, BpirSP-39, coagulant serine protease, Crotalase, Dav-PA, EC 3.4.21.28, EC 3.4.21.29, EC 3.4.21.30, gloshedobin, Habutobin, Lachesis stenophrys venom serine proteinase, metalloproteinase 1, Mutase, acetolactate, Protein C activator, Reptilase, Russell's viper basic coagulant metalloprotease, RVBCMP, RVV protease, snake venom serine protease, TA-2, Thrombin-like enzyme, thrombin-like serine protease, TLE, Vaa serine proteinase homolog 1, VaaSPH-1, VaF1, venom gloshedobin, viper venom serine protease, VLAF, VLBF, VLCII

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.74 venombin A

Substrates Products

Substrates Products on EC 3.4.21.74 - venombin A

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Albumin + H2O
?
show the reaction diagram
-
bovine substrate
-
-
?
azocasein + H2O
?
show the reaction diagram
-
-
-
-
?
benzoyl-Arg-4-nitroanilide + H2O
benzoyl-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
Benzoyl-Phe-Val-Arg 4-nitroanilide + H2O
?
show the reaction diagram
Benzoyl-Pro-Phe-Arg 4-nitroanilide + H2O
Benzoyl-Pro-Phe-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Phe 4-nitrophenyl ester + H2O
benzyloxycarbonyl-Phe + 4-nitrophenol
show the reaction diagram
-
-
-
?
Boc-Leu-Ser-Thr-Arg-p-nitroanilide + H2O
p-nitroaniline + Boc-Leu-Ser-Thr-Arg
show the reaction diagram
-
weaker proteolytic activity than with Bz-DL-Arg-p-nitroaniline
-
-
?
Bovine fibrinogen + H2O
?
show the reaction diagram
Bovine serum albumin + H2O
?
show the reaction diagram
-
-
-
-
?
Bz-DL-Arg-p-nitroanilide + H2O
p-nitroaniline + Bz-DL-Arg
show the reaction diagram
-
proteolytic activity
-
-
?
Carbobenzoxyl-Glu-(alpha-t-butoxy)-Gly-Arg 4-nitroanilide + H2O
Carbobenzoxyl-Glu-(alpha-t-butoxy)-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
carbobenzoxyl-Glu-(alpha-tert-butoxy)-Gly-Arg-4-nitroanilide + H2O
carbobenzoxyl-Glu-(alpha-tert-butoxy)-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
casein + H2O
?
show the reaction diagram
Collagen IV + H2O
?
show the reaction diagram
partial hydrolysis
-
-
?
D-aminobutyric acid-cyclohexylalanyl-Lys 4-nitroanilide + H2O
D-aminobutyric acid-cyclohexylalanyl-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
D-Phe-L-pipecoyl-L-Arg 4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
D-Phe-Pip-Arg-4-nitroanilide + H2O
D-Phe-Pip-Arg + 4-nitroaniline
show the reaction diagram
-
chromogenic substrate
-
-
?
D-Pro-L-Phe-L-Arg 4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
D-Pro-Phe-Arg-4-nitroanilide + H2O
D-Pro-Phe-Arg + 4-nitroaniline
show the reaction diagram
-
chromogenic substrate
-
-
?
D-Val-L-Leu-L-Arg 4-nitroanilide + H2O
?
show the reaction diagram
-
-
-
-
?
D-Val-Leu-Lys-4-nitroanilide + H2O
D-Val-Leu-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Dansyl-Gly-Gly-Val-Arg-Gly methyl ester + H2O
?
show the reaction diagram
factor X + H2O
?
show the reaction diagram
low activity, the heavy chain of factor X is more susceptible to hydrolysis by VaF1 than the light chain whose hydrolysis is observed only after prolonged incubation, partial hydrolysis
-
-
?
factor XIII + H2O
?
show the reaction diagram
Fibrin + H2O
?
show the reaction diagram
-
-
-
-
?
Fibrinogen + H2O
?
show the reaction diagram
fibrinogen + H2O
fibrin + fibrinopeptide A
show the reaction diagram
fibrinogen + H2O
fibrin + fibrinopeptide B
show the reaction diagram
cleavage in the beta-chain
-
-
?
Fibrinogen Aalpha-chains + H2O
?
show the reaction diagram
-
-
-
-
?
fibrinogen B-beta-chain + H2O
?
show the reaction diagram
-
-
-
-
?
fibrinogen-releasing peptide A + H2O
?
show the reaction diagram
-
the enzyme cleaves the Aalpha- and the Bbeta-chains of fibrinogen-releasing peptides A and B
-
-
?
fibrinogen-releasing peptide B + H2O
?
show the reaction diagram
-
the enzyme cleaves the Aalpha- and the Bbeta-chains of fibrinogen-releasing peptides A and B
-
-
?
Fibronectin + H2O
?
show the reaction diagram
partial hydrolysis
-
-
?
Gelatin + H2O
?
show the reaction diagram
-
degradation
-
-
?
H-D-Cyclohexylglycyl-aminobutyric acid-cyclohexylalanyl-Lys 4-nitroanilide + H2O
H-D-Cyclohexylglycyl-aminobutyric acid-cyclohexylalanyl-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
H-D-Cyclohexylglycyl-L-2-aminobutyryl-Arg 4-nitroanilide + H2O
H-D-Cyclohexylglycyl-L-alpha-aminobutyryl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
H-D-Hexahydrotyrosyl-Ala-Arg 4-nitroanilide + H2O
H-D-Hexahydrotyrosyl-Ala-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
H-D-Nle-cyclohexylalanyl-Arg 4-nitroanilide + H2O
H-D-Nle-cyclohexylalanyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
?
H-D-Nle-hexahydrotyrosyl-Lys 4-nitroanilide + H2O
H-D-Nle-hexahydrotyrosyl-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
H-D-Phenylglycyl-Phe-Arg 4-nitroanilide + H2O
H-D-Phenylglycyl-Phe-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
H-D-Pro-hexahydrotyrosyl-Arg 4-nitroanilide + H2O
H-D-Pro-hexahydrotyrosyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
?
Human blood coagulation factor XIII + H2O
Activated human blood coagulation factor XIII
show the reaction diagram
human plasma fibrinogen + H2O
?
show the reaction diagram
-
the fibrinogen degradation products are separated by RP-HPLC followed by mass spectrometric analysis
-
-
?
Insulin B-chain + H2O
?
show the reaction diagram
-
-
-
?
Methylsulfonyl-Leu-Gly-Arg 4-nitroanilide + H2O
Methylsulfonyl-Leu-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide + H2O
N-benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
N-benzoyl-Phe-Val-Arg-4-nitroanilide + H2O
N-benzoyl-Phe-Val-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-DL-arginyl 4-nitroanilide + H2O
Nalpha-benzoyl-DL-arginine + 4-nitroaniline
show the reaction diagram
-
amidolytic activity
-
-
?
Nalpha-Benzoyl-L-Arg cyclohexyl ester + H2O
Nalpha-Benzoyl-L-Arg + cyclohexanol
show the reaction diagram
-
-
-
-
?
Nalpha-Benzoyl-L-Arg ethyl ester + H2O
Nalpha-Benzoyl-L-Arg + ethanol
show the reaction diagram
Nalpha-Benzoyl-L-Arg methyl ester + H2O
Nalpha-Benzoyl-L-Arg + methanol
show the reaction diagram
-
-
-
-
?
Nalpha-benzoyl-L-Arg-4-nitroanilide + H2O
Nalpha-benzoyl-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-arginine-4-nitroanilide + H2O
Nalpha-benzyloxycarbonyl-L-arginine + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
Nalpha-tosyl-Gly-Pro-Arg-4-nitroanilide + H2O
Nalpha-tosyl-Gly-Pro-Arg + 4-nitrolaniline
show the reaction diagram
-
-
-
-
?
Oxidized insulin B-chain + H2O
Hydrolyzed insulin B-chain
show the reaction diagram
-
cleavage sites: Tyr16-Leu17 (isozymes A1-3), Gly23-Phe24, Phe25-Val26 (isozymes A1 and 2), His5-Leu6 (isozyme A1), His10-Leu11, Leu15-Tyr16, Phe24-Phe25 (isozyme A2)
-
?
plasminogen + H2O
?
show the reaction diagram
low activity, partial hydrolysis
-
-
?
prothrombin + H2O
?
show the reaction diagram
low activity, partial hydrolysis
-
-
?
S-2222 + H2O
?
show the reaction diagram
-
chromogenic substrate
-
-
?
Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O
Tosyl-Gly-Pro-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tosyl-Gly-Pro-Lys 4-nitroanilide + H2O
Tosyl-Gly-Pro-Lys + 4-nitroaniline
show the reaction diagram
-
-
-
?
Tosyl-L-arginine methyl ester + H2O
Tosyl-L-arginine + methanol
show the reaction diagram
additional information
?
-