3.4.21.71: Pancreatic elastase II

This is an abbreviated version!
For detailed information about Pancreatic elastase II, go to the full flat file.

Reaction

Preferential cleavage: Leu-/-, Met-/- and Phe-/-. Hydrolyses elastin =

Synonyms

bovine pancreatic elastase, ELA-2, ELA2, Elastase 2, elastase-2, GICP, neutrophil elastase 2

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.71 Pancreatic elastase II

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Results	in table
3	Activating Compound
23	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
73	Disease/ Diagnostics
2	Expression
5	General Information
20	Inhibitors
2	Ki Value [mM]
3	KM Value [mM]
2	Localization
3	Metals/Ions
5	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
12	Organism
1	PDB ID
2	pH Optimum
1	pH Range
1	pI Value
2	Posttranslational Modification
3	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
14	Source Tissue
2	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.71 - Pancreatic elastase II

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

(pro)-filaggrin + H2O

?

2 entries

collagen fiber + H2O

?

Homo sapiens

-

-

732380

-

-

?

elastic fiber + H2O

?

Homo sapiens

-

-

732380

-

-

?

Fibronectin + H2O

?

Homo sapiens

-

-

732913

-

-

?

Somatostatin-14 + H2O

?

Rattus norvegicus

-

hydrolytic enzyme required for intestinal digestion of food stuff, natural substrates are proteins, protein fragments and peptides, greater affinity for natural substrates than for synthetics, specifically involved in the regulation of biological functions of somatostatin-14 in the gastrointestinal tract

34994

-

34994

?

additional information

?

-

3 entries

(pro)-filaggrin + H2O

?

Homo sapiens

-

direct degradation

717908

-

-

?

(pro)-filaggrin + H2O

?

Mus musculus

-

direct degradation

717908

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is formed by activation of proelastase II from mammalian pancreas by trypsin, usually only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species

29645

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is formed by activation of proelastase II from mammalian pancreas by trypsin, usually only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species

29646

-

-

?

additional information

?

-

Homo sapiens

-

the enzyme is formed by activation of proelastase II from mammalian pancreas by trypsin, usually only one of the pancreatic elastases (see also EC 3.4.21.36) is expressed in a given species

29647

-

-

?