3.4.21.71: Pancreatic elastase II

This is an abbreviated version!
For detailed information about Pancreatic elastase II, go to the full flat file.

Word Map on EC 3.4.21.71

3.4.21.71

neutropenia

ii-forming

chymostatin

netherton

proelastase

kostmann

chymostatin-sensitive

tetradecapeptide

1-protease

elastolytic

ii-generating

Reaction

Preferential cleavage: Leu-/-, Met-/- and Phe-/-. Hydrolyses elastin =

Synonyms

bovine pancreatic elastase, ELA-2, ELA2, Elastase 2, elastase-2, GICP, neutrophil elastase 2

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.71 Pancreatic elastase II

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Results	in table
3	Activating Compound
23	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
73	Disease/ Diagnostics
2	Expression
5	General Information
20	Inhibitors
2	Ki Value [mM]
3	KM Value [mM]
2	Localization
3	Metals/Ions
5	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
12	Organism
1	PDB ID
2	pH Optimum
1	pH Range
1	pI Value
2	Posttranslational Modification
3	Purification (Commentary)
1	Reaction
1	Reaction Type
12	Reference
14	Source Tissue
2	Specific Activity [micromol/min/mg]
20	Substrates and Products (Substrate)
2	Subunits
14	Synonyms
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.4.21.71 - Pancreatic elastase II

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3,4-dichloroisocoumarin

Rattus norvegicus

causes total inhibition

34994

alpha1-Aantichymotrypsin

chymostatin

Cu2+

1 mM, 50% inhibition

diisopropyl fluorophosphate

Rattus norvegicus

causes total inhibition

Elastinal

Hg2+

1 mM, 50% inhibition

Human alpha1-proteinase inhibitor

leupeptin

N-alpha-tosyl-L-lysine-chloromethyl ketone

Rattus norvegicus

most potent inhibitor

34994

NCDC

Bos taurus

653034

phenylmethylsulfonyl fluoride

2 entries

secretory leukoprotease inhibitor

2 entries

skin-derived antileukoprotease

2 entries

Soybean trypsin inhibitor

Rattus norvegicus

most potent inhibitor

34994

additional information

2 entries