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3.4.21.61: Kexin

This is an abbreviated version!
For detailed information about Kexin, go to the full flat file.

Word Map on EC 3.4.21.61

Reaction

Cleavage of -Lys-Arg-/- and -Arg-Arg-/- bonds to process yeast alpha-factor pheromone and killer toxin precursors =

Synonyms

adrenorphin-Gly-generating enzyme, ASP, BLI-4, corin activating enzyme, EC 3.4.22.23, endoproteinase Kex2p, Gene KEX2 dibasic proteinase, HuPCSK6, Kex 2p proteinase, Kex2, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, Kex2 proteinase, Kex2-660, Kex2-like endoproteinase, Kex2-like precursor protein processing endoprotease, Kex2p, kexin, More, NARC-1, Paired-basic endopeptidase, PC 1/3, PC1, PC1/3, PC2, PCSK type 9, PCSK6, PCSK9, plasma proprotein convertase subtilisin-kexin type 9, pro-protein convertase subtilisin/kexin type 9, prohormone convertase 1, prohormone convertase 1/3, prohormone convertase 2, prohormone processing protease, Prohormone-processing endoprotease, Prohormone-processing KEX2 proteinase, Prohormone-processing proteinase, Proprotein convertase, proprotein convertase 1/3, proprotein convertase Kex2, proprotein convertase subtilisin kexin type 9, proprotein convertase subtilisin kexin-9, proprotein convertase subtilisin-like/kexin type 9, proprotein convertase subtilisin/kexin 6, proprotein convertase subtilisin/kexin type 6, proprotein convertase subtilisin/kexin type 9, proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9, proprotein processing protease, Protease KEX2, Proteinase Kex2p, Proteinase yscF, Proteinase, prohormone-processing, Yeast KEX2 protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.61 Kexin

Turnover Number

Turnover Number on EC 3.4.21.61 - Kexin

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
21.6
Ac-AYKK 4-methylcoumarin 7-amide
-
pH 7.0, 21°C
2700
Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide
-
pH 7.0, 37°C
300
Ac-Nle-YKK 4-methylcoumarin 7-amide
-
pH 7.0, 21°C
3000
Ac-Nle-YKR 4-methylcoumarin 7-amide
-
pH 7.0, 21°C
2640
benzyloxycarbonyl-Ala-Tyr-Lys-Lys 4-methylcoumarin 7-amide
-
pH 7.0, 21°C
2940
D-Ac-Nle-Tyr-Lys-Arg 4-methylcoumarin 7-amide
-
pH 7.0, 37°C
11.4
t-butyloxycarbonyl-EKK 4-methylcoumarin 7-amide
-
pH 7.0, 21°C
366
t-butyloxycarbonyl-QGR 4-methylcoumarin 7-amide
-
pH 7.0, 21°C