3.4.21.61: Kexin

This is an abbreviated version!
For detailed information about Kexin, go to the full flat file.

Reaction

Cleavage of -Lys-Arg-/- and -Arg-Arg-/- bonds to process yeast alpha-factor pheromone and killer toxin precursors =

Synonyms

adrenorphin-Gly-generating enzyme, ASP, BLI-4, corin activating enzyme, EC 3.4.22.23, endoproteinase Kex2p, Gene KEX2 dibasic proteinase, HuPCSK6, Kex 2p proteinase, Kex2, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, Kex2 proteinase, Kex2-660, Kex2-like endoproteinase, Kex2-like precursor protein processing endoprotease, Kex2p, kexin, More, NARC-1, Paired-basic endopeptidase, PC 1/3, PC1, PC1/3, PC2, PCSK type 9, PCSK6, PCSK9, plasma proprotein convertase subtilisin-kexin type 9, pro-protein convertase subtilisin/kexin type 9, prohormone convertase 1, prohormone convertase 1/3, prohormone convertase 2, prohormone processing protease, Prohormone-processing endoprotease, Prohormone-processing KEX2 proteinase, Prohormone-processing proteinase, Proprotein convertase, proprotein convertase 1/3, proprotein convertase Kex2, proprotein convertase subtilisin kexin type 9, proprotein convertase subtilisin kexin-9, proprotein convertase subtilisin-like/kexin type 9, proprotein convertase subtilisin/kexin 6, proprotein convertase subtilisin/kexin type 6, proprotein convertase subtilisin/kexin type 9, proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9, proprotein processing protease, Protease KEX2, Proteinase Kex2p, Proteinase yscF, Proteinase, prohormone-processing, Yeast KEX2 protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.61 Kexin

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Results	in table
10	Activating Compound
23	AA Sequence
24	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Crystallization (Commentary)
9474	Disease/ Diagnostics
9	Expression
31	General Information
6	IC50 Value
73	Inhibitors
14	Ki Value [mM]
9	KM Value [mM]
24	Localization
10	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
209	Organism
10	PDB ID
6	pH Optimum
1	pH Range
10	pH Stability
5	Posttranslational Modification
60	Protein Variants
18	Purification (Commentary)
2	Reaction
1	Reaction Type
70	Reference
71	Source Tissue
2	Storage Stability
108	Substrates and Products (Substrate)
4	Subunits
120	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.21.61 - Kexin

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00823

5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14),22-diene-3beta,7beta-diol

Homo sapiens

Q8NBP7

pH and temperature not specified in the publication

753959

0.01846

adenosine

Homo sapiens

Q8NBP7

pH and temperature not specified in the publication

753959

0.00804

Berberine

Homo sapiens

Q8NBP7

pH and temperature not specified in the publication

753959

0.00718

hanabiratakelide A

Homo sapiens

Q8NBP7

pH and temperature not specified in the publication

753959

0.0201

sparoside A

Homo sapiens

Q8NBP7

pH and temperature not specified in the publication

753959

additional information

additional information

Homo sapiens

Q8NBP7

at 20°C in 0.05 ml of buffer containing 10 mM Hepes, pH 7.4, 150 mM NaCl, 0.1 mM CaCl2, and 0.05% (w/v) bovine serum albumin: 0.0000048 mM with 1G08 fragment antigen binding, when wild-type expressed in HEK-293 cells, 0.0000150 mM with 1G08 fragment antigen binding, when wild-type expressed in Hep-G2 cells, 0.001 mM with 1G08 fragment antigen binding, when mutant R549A , mutant R580A/R582A and mutant E607A/K609A/E612N expressed in HEK-293 cells

709095

-