3.4.21.61: Kexin

This is an abbreviated version!
For detailed information about Kexin, go to the full flat file.

Reaction

Cleavage of -Lys-Arg-/- and -Arg-Arg-/- bonds to process yeast alpha-factor pheromone and killer toxin precursors =

Synonyms

adrenorphin-Gly-generating enzyme, ASP, BLI-4, corin activating enzyme, EC 3.4.22.23, endoproteinase Kex2p, Gene KEX2 dibasic proteinase, HuPCSK6, Kex 2p proteinase, Kex2, Kex2 endopeptidase, Kex2 endoprotease, Kex2 endoproteinase, Kex2 protease, Kex2 proteinase, Kex2-660, Kex2-like endoproteinase, Kex2-like precursor protein processing endoprotease, Kex2p, kexin, More, NARC-1, Paired-basic endopeptidase, PC 1/3, PC1, PC1/3, PC2, PCSK type 9, PCSK6, PCSK9, plasma proprotein convertase subtilisin-kexin type 9, pro-protein convertase subtilisin/kexin type 9, prohormone convertase 1, prohormone convertase 1/3, prohormone convertase 2, prohormone processing protease, Prohormone-processing endoprotease, Prohormone-processing KEX2 proteinase, Prohormone-processing proteinase, Proprotein convertase, proprotein convertase 1/3, proprotein convertase Kex2, proprotein convertase subtilisin kexin type 9, proprotein convertase subtilisin kexin-9, proprotein convertase subtilisin-like/kexin type 9, proprotein convertase subtilisin/kexin 6, proprotein convertase subtilisin/kexin type 6, proprotein convertase subtilisin/kexin type 9, proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9, proprotein processing protease, Protease KEX2, Proteinase Kex2p, Proteinase yscF, Proteinase, prohormone-processing, Yeast KEX2 protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.61 Kexin

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Results	in table
10	Activating Compound
23	AA Sequence
24	Application
1	CAS Registry Number
24	Cloned(Commentary)
3	Crystallization (Commentary)
9474	Disease/ Diagnostics
9	Expression
31	General Information
6	IC50 Value
73	Inhibitors
14	Ki Value [mM]
9	KM Value [mM]
24	Localization
10	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
209	Organism
10	PDB ID
6	pH Optimum
1	pH Range
10	pH Stability
5	Posttranslational Modification
60	Protein Variants
18	Purification (Commentary)
2	Reaction
1	Reaction Type
70	Reference
71	Source Tissue
2	Storage Stability
108	Substrates and Products (Substrate)
4	Subunits
120	Synonyms
3	Temperature Optimum [°C]
8	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.21.61 - Kexin

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystallized by hanging drop method, in complex with an Ala-Lys-Arg boronic acid inhibitor, space group P6(5)22, a = b = 113.8 A, c = 370.2 A

Saccharomyces cerevisiae

P13134

650220

in complex with Ac-Arg-Glu-Lys-Arg-peptidyl boronic acid inhibitor

Saccharomyces cerevisiae

-

667596

Kex2 in complex with the Ac-R-E-R-K-chloromethylketone, containing a noncognate lysine at the P1 position. Secondary subsite in the S1 pocket is present, which recognizes and binds the P1 lysine in a more shallow fashion than arginine. Kex2 contains well defined subsites that have optimally arranged electrostatic charge that positions correct substrates for hydrolysis. Chemical nature of the peptidyl inhibitor has little effect on ligand positioning at the active site in the alkylated enzyme forms

Saccharomyces cerevisiae

-

689779