3.4.21.60: Scutelarin
This is an abbreviated version!
For detailed information about Scutelarin, go to the full flat file.
Word Map on EC 3.4.21.60
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3.4.21.60
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clot
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anticoagulant
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coagulation
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venom
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thromboplastin
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snake
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chromogenic
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dabigatran
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bleeding
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thrombocytopenia
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procoagulant
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carinatus
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heparin-induced
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meizothrombin
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etexilate
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viper
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argatroban
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echis
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r-hirudin
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lepirudin
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prothrombinase
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rivaroxaban
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textilis
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pseudonaja
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lonomia
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anti-factor
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anti-xa
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doacs
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apixaban
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idarucizumab
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hemoclot
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bivalirudin
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elapid
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prothrombinase-induced
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obliqua
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prethrombin-2
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tropidechis
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melagatran
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medicine
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edoxaban
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saw-scaled
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peg-hirudin
- 3.4.21.60
- clot
-
anticoagulant
- coagulation
- venom
- thromboplastin
- snake
-
chromogenic
- dabigatran
-
bleeding
- thrombocytopenia
-
procoagulant
- carinatus
-
heparin-induced
- meizothrombin
-
etexilate
- viper
- argatroban
- echis
-
r-hirudin
- lepirudin
- prothrombinase
- rivaroxaban
- textilis
- pseudonaja
- lonomia
-
anti-factor
-
anti-xa
-
doacs
- apixaban
-
idarucizumab
-
hemoclot
- bivalirudin
-
elapid
-
prothrombinase-induced
- obliqua
- prethrombin-2
-
tropidechis
- melagatran
- medicine
- edoxaban
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saw-scaled
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peg-hirudin
Reaction
selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments =
Synonyms
cotiaractivase, cotiarinase, EC 3.4.99.28, ecarin, Lopap, Proteinase, Oxyuranus scutellatus prothrombin-activating, prothrombin activator, pseutarin C, scuterin, Taipan activator
ECTree
3.4.21.60 ScutelarinAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.4.21.60 - Scutelarin
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide + H2O
benzoyl-Ile-Glu-Gly-Arg + 4-nitroaniline
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?
prothrombin + H2O
active thrombin + thrombin fragment 1 + prothrombin 1
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cotiarinase is a snake venom serine proteinase that generated thrombin upon incubation with prothrombin, limited proteolysis of this protein to release prothrombin 1, fragment 1 and thrombin
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?
prothrombin + H2O
alpha-thrombin + ?
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cleavage at positions Arg271-Thr272 and Arg320-Ile321
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?
prothrombin + H2O
thrombin + inactive prothrombin fragments
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?
prothrombin + H2O
?
ecarin converts prothrombin to thrombin also if the prothrombin is not gamma-carboxylated
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?
prothrombin + H2O
thrombin + ?
intermediate products are fragments similar to prethrombin-2 and fragment 1.2
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?
prothrombin + H2O
thrombin + meizothrombin
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conversion in absence of coagulation factor Va
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?
prothrombin + H2O
thrombin + meizothrombin
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cleavage of Arg274-Thr275 and Arg323-Ile324
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?
additional information
?
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the enzyme does not show fibrinogen-clotting, platelet-aggregating, fibrinogenolytic and factor X activating activities. Very low amidolytic activity as detected by the hydrolysis of the chromogenic substrates D-Phe-Pip-Arg-4-naphthyl amide and D-Val-Leu-Lys-4-naphthylamide
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?
additional information
?
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enzyme acts on cell survival, regulating the expression of molecules as NO and avoiding cell death. Enzyme triggers release of interleukin 8, inhibits platelet activation and chemotaxis and causes uncoagulable blood by fibrinogen depletion
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?
additional information
?
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no hydrolysis of: benzoyl-Phe-Arg 4-nitroanilide, D-Val-Leu-Lys 4-nitroanilide
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?
