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3.4.21.60: Scutelarin

This is an abbreviated version!
For detailed information about Scutelarin, go to the full flat file.

Word Map on EC 3.4.21.60

Reaction

selective cleavage of Arg-/-Thr and Arg-/-Ile in prothrombin to form thrombin and two inactive fragments =

Synonyms

cotiaractivase, cotiarinase, EC 3.4.99.28, ecarin, Lopap, Proteinase, Oxyuranus scutellatus prothrombin-activating, prothrombin activator, pseutarin C, scuterin, Taipan activator

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.60 Scutelarin

Inhibitors

Inhibitors on EC 3.4.21.60 - Scutelarin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
benzamidine
-
inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
bothrojaracin
-
inhibits prothrombin activation
-
Bovine pancreas trypsin inhibitor
-
inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
-
EDTA
-
5 mM, complete inhibition
hirudin54-65(SO-3)-
-
-
Inhibitor present in the venom of Oxyuranus scutellatus
-
inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
-
NaCl
-
inhibits activation of prethrombin 2, no effect on reaction with meizothrombin
Nalpha-p-toluenesulfonyl-L-Arg methyl ester
-
inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
NaSCN
-
bovine factor Va restores activity; reduces ability to activate prothrombin but has no effect on amidolytic activity
phenyl methyl sulfonylfluoride
complete inhibition
S2238
-
noncompetitive
Soybean trypsin inhibitor
-
inhibits hydrolysis of benzoyl-Ile-Glu-Gly-Arg 4-nitroanilide
-
additional information
-