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3.4.21.50: lysyl endopeptidase

This is an abbreviated version!
For detailed information about lysyl endopeptidase, go to the full flat file.

Word Map on EC 3.4.21.50

Reaction

Preferential cleavage: Lys-/-, including -Lys-/-Pro- =

Synonyms

Achrombacter protease I, Achromobacter lysyl endopeptidase, Achromobacter protease I, Achromobacter proteinase I, achromopeptidase, API, caseinase, endo-Lys-C protease, endopeptidase Lys-C, endoproteinase, endoproteinase Lys-C, endoproteinase lysine-C, KGP, LEP, Lys-C, Lys-C endoproteinase, Lys-specific serine endopeptidase, lysine endoproteinase, lysine specific gingipain, lysine specific protease, lysine specific proteinase, lysine-specific protease, Lysobacter lysyl endoproteinase, lysyl bond specific proteinase, Lysyl endopeptidase, protease I, protease IV, proteinase, Achromobacter lyticus alkaline I, proteinase, lysine specific, proteinase, Pseudomonas lyticus alkaline , I, Ps-1, Pseudomonas aeruginosa lysine -specific protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.50 lysyl endopeptidase

KM Value

KM Value on EC 3.4.21.50 - lysyl endopeptidase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
20
benzoyl-Arg ethyl ester
-
-
0.091
benzoyl-Lys methyl ester
-
-
0.32
benzoyl-Lys-NH2
-
-
0.08 - 0.11
Lys-p-nitroanilide
1.59
N-acetyl-L-lysine
-
pH 9, rate of carboxyl oxygen exchange reaction by Lys-C is accelerated at acidic pH conditions.
0.07 - 0.09
N-benzoyl-L-Lys p-nitroanilide
0.63 - 1
N-benzoyl-L-Orn methyl ester
3.09
N-tert-butyloxycarbonyl-Ala-Ala-Lys-4-methylcoumarin 7-amide
-
-
3.11
N-tert-butyloxycarbonyl-Ala-Lys-4-methylcoumarin 7-amide
-
-
41
N-tert-butyloxycarbonyl-Lys-4-methylcoumarin 7-amide
-
-
0.034
N-tosyl-Gly-Pro-Lys-p-nitroanilide
-
-
2.5 - 35.7
N-tosyl-L-Arg methyl ester
0.053 - 0.1
N-tosyl-L-Lys methyl ester
0.0028 - 0.024
tert-butyloxycarbonyl-Ala-Ala-Lys-7-amido-4-methylcoumarin
0.0037 - 0.042
tert-butyloxycarbonyl-Ala-Lys-7-amido-4-methylcoumarin
0.029 - 0.081
tert-butyloxycarbonyl-Lys-7-amido-4-methylcoumarin
0.0007 - 0.032
tert-butyloxycarbonyl-Val-Leu-Lys-7-amido-4-methylcoumarin
0.034 - 0.25
tosyl-Gly-Pro-Lys-p-nitroanilide
0.053
Tosyl-Lys methyl ester
-
pH 8.0
0.0019
Trypsinogen
-
-
0.33
Val-Leu-Lys-p-nitroanilide
-
-