3.4.21.45: complement factor I

This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.

Reaction

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =

Synonyms

C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.45 complement factor I

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Results	in table
24	Activating Compound
30	AA Sequence
17	Application
1	CAS Registry Number
16	Cloned(Commentary)
13	Cofactor
1	Crystallization (Commentary)
357	Disease/ Diagnostics
1	Expression
10	General Information
1	General Stability
39	Inhibitors
20	KM Value [mM]
7	Localization
2	Metals/Ions
61	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
56	Organism
8	PDB ID
5	pH Optimum
1	pH Range
1	pH Stability
1	pI Value
12	Posttranslational Modification
79	Protein Variants
20	Purification (Commentary)
1	Reaction
1	Reaction Type
53	Reference
1	Renatured (Commentary)
74	Source Tissue
9	Specific Activity [micromol/min/mg]
3	Storage Stability
95	Substrates and Products (Substrate)
13	Subunits
53	Synonyms
12	Temperature Optimum [°C]
1	Temperature Stability [°C]

Substrates Products

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

benzoyl-Arg-4-methylcoumaryl-7-amide + H2O

benzoyl-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

benzyloxycarbonyl-Gly-Gly-Arg-4-methylcoumaryl-7-amide + H2O

benzyloxycarbonyl-Gly-Gly-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

benzyloxycarbonyl-Gly-Pro-Arg-4-methylcoumaryl-7-amide + H2O

benzyloxycarbonyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

benzyloxycarbonyl-Leu-Leu-Arg-4-methylcoumaryl-7-amide + H2O

benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide + H2O

benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

Boc-Asp(benzyl)-Pro-Arg-4-methylcoumarin 7-amide + H2O

?

Homo sapiens

-

-

732047

-

-

?

complement component C3 + H2O

?

Homo sapiens

P05156

structural but not functional roles for the three N-linked oligosaccharide chains indicated, N-linked glycan pool composition of the heavy and light chains indicated

683180

-

-

?

complement component C3(NH3) + H2O

?

Homo sapiens

-

cleaved by SP domain-form

667666

-

-

?

complement component C3b + H2O

?

9 entries

complement component C3b + H2O

complement component C3c + ?

16 entries

complement component C3b + H2O

complement component iC3b

Homo sapiens

-

-

667666, 669058, 669758

a major opsonin

-

?

complement component C3b + H2O

complement component iC3b + ?

3 entries

complement component C3b + H2O

inactivated C3b + ?

3 entries

complement component C3bi + H2O

?

Homo sapiens

-

the breakdown of human erythrocyte-bound C3bi molecules in serum or plasma is mediated only by factor I

95486

-

-

?

complement component C3bi + H2O

complement component C3c + ?

Homo sapiens

-

complement component C3bi bound to human erythrocytes is rapidly cleaved, unlike complement component C3bi bound to other species

95486

-

95486

?

complement component C4b + H2O

?

8 entries

complement component C4b + H2O

complement component C4c + C4d

8 entries

complement factor C3b + H2O

?

Homo sapiens

-

-

708380

-

-

?

complement factor C4b + H2O

?

Homo sapiens

-

-

708380

-

-

?

FGR-7-amido-4-methylcoumarin + H2O

FGR + 7-amino-4-methylcoumarin

Homo sapiens

-

-

699340

-

-

?

methylsulfonyl-D-Phe-Gly-Arg-4-methylcoumaryl-7-amide + H2O

methylsulfonyl-D-Phe-Gly-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

N-alpha-tert-butyloxycarbonyl-Val-Leu-Lys-4-methylcoumaryl-7-amide + H2O

N-alpha-tert-butyloxycarbonyl-Val-Pro-Lys + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide + H2O

N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

Phe-Gly-Arg-4-methylcoumaryl-7-amide + H2O

Phe-Gly-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

Pro-Phe-Arg-4-methylcoumaryl-7-amide + H2O

Pro-Phe-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

tert-butyloxycarbonyl-Asp(benzyl ester)-Pro-Arg-4-methylcoumaryl-7-amide + H2O

tert-butyloxycarbonyl-Asp(benzyl ester)-Pro-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

652686

-

652686

?

tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin + H2O

?

Homo sapiens

-

-

708380

-

-

?

tert-butyloxycarbonyl-Ile-Glu-Gly-Arg-4-methylcoumaryl-7-amide + H2O

tert-butyloxycarbonyl-Ile-Glu-Gly-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

tert-butyloxycarbonyl-Phe-Ser-Arg-4-methylcoumaryl-7-amide + H2O

tert-butyloxycarbonyl-Phe-Ser-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

low activity

652686

-

652686

?

additional information

?

-

9 entries

complement component C3b + H2O

?

Cavia porcellus

-

enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b

95484

-

-

?

complement component C3b + H2O

?

Cynoglossus semilaevis

A0A0H4CX09

-

753374

-

-

?

complement component C3b + H2O

?

Homo sapiens

-

-

697732, 708380, 753137

-

-

?

complement component C3b + H2O

?

Homo sapiens

-

cleavage at five different sites in the alpha-chain, generating complement component C3d.g-like fragments with three different N-terminal and two different C-terminal ends

95485

-

-

?

complement component C3b + H2O

?

Homo sapiens

-

degradation in presence of C4b binding protein and factor H

732690

-

-

?

complement component C3b + H2O

?

Mus musculus

-

-

95494

-

-

?

complement component C3b + H2O

?

Nipah henipavirus

-

-

732425

-

-

?

complement component C3b + H2O

?

Rattus norvegicus

-

cleavage of three peptide bonds in the alpha chain of complement component C3b, thereby inactivating this protein

95493

-

-

?

complement component C3b + H2O

?

Rattus norvegicus

-

enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha-chains of complement component C4b and complement component C4b

95484

-

-

?

complement component C3b + H2O

complement component C3c + ?

Cavia porcellus

-

-

95484

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

-

-

95488, 95489, 95491

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

-

-

95492

-

95492

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

-

-

95497

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

P05156

-

683884, 683888, 683892

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

-

phosphorylation of complement component C3b inhibits the cleavage of the alpha'-chain of complement component C3b

95498

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

-

cleavage at five different sites in the alpha-chain, generating complement component C3d.g-like fragments with three different N-terminal and two different C-terminal ends

95485

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

P05156

mutation of complement factor I associated to atypical hemolytic uremic syndrome analyzed, activity observed in mutant protein comparable to wild-type

683883

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

P05156

complement factor I mutants predisposing to atypical hemolytic uremic syndrome analyzed, cofactor function of complement components C3b and Cb4 tested

683892

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

P05156

complement factor I production of human keratinocytes analyzed, with and without stimulation by IFN-gamma, IL-1alpha, IL-6, TNF-alpha, TGF-beta1

683884

-

-

?

complement component C3b + H2O

complement component C3c + ?

Homo sapiens

P05156

production of complement factor I in non-small cell lung cancer cell lines analyzed

683888

-

-

?

complement component C3b + H2O

complement component C3c + ?

Mus musculus

Q61129

-

683705

-

-

?

complement component C3b + H2O

complement component C3c + ?

Mus musculus

Q61129

studies on membranoproliferative glomerulonephritis, potential relation to complement factor I analyzed

683705

-

-

?

complement component C3b + H2O

complement component C3c + ?

Rattus norvegicus

-

-

95484

-

-

?

complement component C3b + H2O

complement component C3c + ?

Rattus norvegicus

-

cleavage of three peptide bonds in the alpha-chain of complement component C3b

95493

-

-

?

complement component C3b + H2O

complement component C3c + ?

Sus scrofa

-

-

95497

-

-

?

complement component C3b + H2O

complement component iC3b + ?

Homo sapiens

-

cleavage does not require presence of factor H

651495

-

651495

?

complement component C3b + H2O

complement component iC3b + ?

Homo sapiens

-

the complement C3 fragments C3b and iC3b appear on the surface of several virulent Staphylococcus aureus strains of capsule polysaccharide type 5 and 8. Factor I mediates the cleavage of C3b to iC3b on the surface of Staphylococcus aureus and appears to be able to function without the serum cofactor, factor H

651495

-

651495

?

complement component C3b + H2O

complement component iC3b + ?

Nipah henipavirus

-

Nipah virus-dependent inactivation of C3b only occurs with the cofactors factor H and soluble CR1 but not with CD46. When factor I is coupled with factor H, this cleavage can occur at two possible sites in the alpha' chain: R1281 and R1298, sites 1 and 2. In the presence of CR1, factor I can cleave the alpha' chain at sites 1 and 2 but also at an additional site at R932

732425

-

-

?

complement component C3b + H2O

inactivated C3b + ?

Homo sapiens

-

-

699369

-

-

?

complement component C3b + H2O

inactivated C3b + ?

Homo sapiens

-

factor I mediates cleavage of C3b between Arg1298 and Ser1299

699340

-

-

?

complement component C3b + H2O

inactivated C3b + ?

Mus musculus

-

-

699340

-

-

?

complement component C4b + H2O

?

Bos taurus

-

-

754553

-

-

?

complement component C4b + H2O

?

Cavia porcellus

-

enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b

95484

-

-

?

complement component C4b + H2O

?

Cynoglossus semilaevis

A0A0H4CX09

-

753374

-

-

?

complement component C4b + H2O

?

Homo sapiens

-

-

667666, 669058, 669758, 697732, 708380, 753137, 754553

-

-

?

complement component C4b + H2O

?

Homo sapiens

-

degradation in presence of C4b binding protein and factor H

732690

-

-

?

complement component C4b + H2O

?

Mus musculus

-

-

95494

-

-

?

complement component C4b + H2O

?

Rattus norvegicus

-

cleavage of two peptide bonds in the alpha chain of complement component C4b, thereby inactivating this protein

95493

-

-

?

complement component C4b + H2O

?

Rattus norvegicus

-

enzyme is involved in the regulation of complement activation, it catalyzes the limited proteolysis of the alpha chains of complement component C4b and C4b

95484

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Cavia porcellus

-

-

95484

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Homo sapiens

-

-

95488, 95489, 95491

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Homo sapiens

P05156

-

683883, 683884

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Homo sapiens

-

-

683884

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Homo sapiens

P05156

-

683888, 683892

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Homo sapiens

-

a nicked form of complement component C4b, complement component C4b', consisting of four disulfide-linked polypeptide chains, is formed as an intermediate product before cleavage of complement component C4b into complement component C4c and complement component C4d

95490

-

95490

?

complement component C4b + H2O

complement component C4c + C4d

Rattus norvegicus

-

-

95484

-

-

?

complement component C4b + H2O

complement component C4c + C4d

Rattus norvegicus

-

cleavage of two peptide bonds in the alpha chain of C4b

95493

-

-

?

additional information

?

-

Homo sapiens

-

no cleavage of H-Gly-Arg-7-amido-4-methylcoumarin, MeOSuc-Ala-Ala-Pro-Val-7-amido-4-methylcoumarin or N-alpha-tert-butyloxycarbonyl-leu-Gly-Arg-7-amido-4-methylcoumarin

652686

-

652686

?

additional information

?

-

Homo sapiens

P05156

complement factor I production analyzed by RT-PCR

683888

-

-

?

additional information

?

-

Homo sapiens

P05156

complement factor I production analyzed, no mRNA expression detected

683888

-

-

?

additional information

?

-

Homo sapiens

P05156

production of complement factor I analyzed, no mRNA expression detected

683888

-

-

?

additional information

?

-

Homo sapiens

P05156

human factor I has little species-specificity like pig factor I, according to the relatively high homology of the AA sequences in the serine protease region, in comparison with those of membrane complement regulatory proteins

701342

-

-

?

additional information

?

-

Homo sapiens

-

human factor I has little species-specificity like pig factor I, according to the relatively high homology of the AA sequences in the serine protease region, in comparison with those of membrane complement regulatory proteins

701342

-

-

?

additional information

?

-

Homo sapiens

-

Staphylococcus aureus expressing clumping factor A (ClfA) (P336A Y338S) is more susceptible to complement-mediated phagocytosis than a ClfA-null mutant or the wild type. Unlike clumping factor A, the mutant ClfA(P336A Y338S) does not enhance factor I cleavage of C3b to iC3b and inhibits the cofactor function of factor H. Fibrinogen enhances factor I binding to clumping factor A and the Staphylococcus aureus surface

708715

-

-

?

additional information

?

-

Nipah henipavirus

-

no activity with complement component C4b

732425

-

-

?

additional information

?

-

Sus scrofa

-

can be expressed on xenogeneic cell membranes

701342

-

-

?