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3.4.21.45: complement factor I

This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.

Word Map on EC 3.4.21.45

Reaction

Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =

Synonyms

C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.45 complement factor I

Reference

Reference on EC 3.4.21.45 - complement factor I

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Davis III, A.E.; Alper, C.A.
Factor I (C3b inactivator) the complement regulatory protease
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
5
553-558
1984
Cavia porcellus, Rattus norvegicus
-
Manually annotated by BRENDA team
Ekdahl, K.N.; Nilsson, U.R.; Nilsson, B.
Inhibition of factor I by diisopropylfluorophosphate. Evidence of conformational changes in factor I induced by C3b and additional studies on the specificity of factor I
J. Immunol.
144
4269-4274
1990
Homo sapiens
Manually annotated by BRENDA team
Medicus, R.G.; Melamed, J.; Arnaout, M.A.
Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules
Eur. J. Immunol.
13
465-470
1983
Homo sapiens
Manually annotated by BRENDA team
Kaidoh, T.; Gigli, I.
Phylogeny of regulatory proteins of the complement system. Isolation and characterization of a C4b/C3b inhibitor and a cofactor from sand bass plasma
J. Immunol.
142
1605-1613
1989
Paralabrax nebulifer
Manually annotated by BRENDA team
Hsiung, L.; Barclay, A.N.; Brandon, M.R.; Sim, E.; Porter, R.R.
Purification of human C3b inactivator by monoclonal-antibody affinity chromatography
Biochem. J.
203
293-298
1982
Homo sapiens
Manually annotated by BRENDA team
Crossley, L.G.
C3b inactivator and beta1H
Methods Enzymol.
80
112-124
1981
Homo sapiens
Manually annotated by BRENDA team
Nagasawa, S.; Ichihara, C.; Stroud, R.M.
Cleavage of C4b by C3b inactivator: production of a nicked form of C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator
J. Immunol.
125
578-582
1980
Homo sapiens
Manually annotated by BRENDA team
Fujita, T.; Nussenzweig, V.
The role of C4-binding protein and beta1H in proteolysis of C4b and C3b
J. Exp. Med.
150
267-276
1979
Homo sapiens
Manually annotated by BRENDA team
Gaither, T.A.; Hammer, C.H.; Frank, M.M.
Studies of the molecular mechanisms of C3b inactivation and a simplified assay of beta1H and the C3b inactivator (C3bINA)
J. Immunol.
123
1195-1204
1979
Homo sapiens
Manually annotated by BRENDA team
Schlaf, G.; Rothermel, E.; Oppermann, M.; Schieferdecker, H.L.; Jungermann, K.
Rat complement factor I: molecular cloning, sequencing and expression in tissue and isolated cells
Immunology
94
464-474
1999
Rattus norvegicus
Manually annotated by BRENDA team
Minta, J.O.; Wong, M.J.; Kozak, C.A.; Kunnath-Muglia, L.M.; Goldberger, G.
cDNA Cloning, sequencing and chromosomal assignment of the gene for mouse complement factor I (C3b/C4b inactivator): Identification of a species specific divergent segment in factor I
Mol. Immunol.
33
101-112
1996
Mus musculus
Manually annotated by BRENDA team
Kunnath-Muglia, L.M.; Chang, G.H.; Sim, R.B.; Day, A.J.; Ezekowitz, R.A.B.
Characterization of Xenopus laevis complement factor I structure - conservation of modular structure except for an unusual insert not present in human factor
Mol. Immunol.
30
1249-1256
1993
Xenopus laevis
Manually annotated by BRENDA team
DiScipio, R.G.
The fractionation of human plasma proteins
Protein Expr. Purif.
5
178-186
1994
Homo sapiens
Manually annotated by BRENDA team
Van den Berg, C.W.; Perez de la Lastra, J.M.; Llanes, D.; Morgan, B.P.
Purification and characterization of the pig analogue of human membrane cofactor protein (CD46/MCP)
J. Immunol.
158
1703-1709
1997
Homo sapiens, Sus scrofa
Manually annotated by BRENDA team
Ekdahl, K.N.; Nilsson, B.
Phosphorylation of complement component C3 and C3 fragments by a human platelet protein kinase
J. Immunol.
154
6402-6510
1995
Homo sapiens
-
Manually annotated by BRENDA team
Cunnion, K.M.; Hair, P.S.; Buescher, E.S.
Cleavage of complement C3b to iC3b on the surface of Staphylococcus aureus is mediated by serum complement factor I
Infect. Immun.
72
2858-2863
2004
Homo sapiens
Manually annotated by BRENDA team
Tsiftsoglou, S.A.; Sim, R.B.
Human complement factor I does not require cofactors for cleavage of synthetic substrates
J. Immunol.
173
367-375
2004
Homo sapiens
Manually annotated by BRENDA team
Tsiftsoglou, S.A.; Willis, A.C.; Li, P.; Chen, X.; Mitchell, D.A.; Rao, Z.; Sim, R.B.
The catalytically active serine protease domain of human complement factor I
Biochemistry
44
6239-6249
2005
Homo sapiens
Manually annotated by BRENDA team
Kavanagh, D.; Kemp, E.J.; Mayland, E.; Winney, R.J.; Duffield, J.S.; Warwick, G.; Richards, A.; Ward, R.; Goodship, J.A.; Goodship, T.H.
Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome
J. Am. Soc. Nephrol.
16
2150-2155
2005
Homo sapiens
Manually annotated by BRENDA team
Cunnion, K.M.; Buescher, E.S.; Hair, P.S.
Serum complement factor I decreases Staphylococcus aureus phagocytosis
J. Lab. Clin. Med.
146
279-286
2005
Homo sapiens
Manually annotated by BRENDA team
Tsiftsoglou, S.A.; Arnold, J.N.; Roversi, P.; Crispin, M.D.; Radcliffe, C.; Lea, S.M.; Dwek, R.A.; Rudd, P.M.; Sim, R.B.
Human complement factor I glycosylation: structural and functional characterisation of the N-linked oligosaccharides
Biochim. Biophys. Acta
1764
1757-1766
2006
Homo sapiens (P05156), Homo sapiens
Manually annotated by BRENDA team
Rose, K.L.; Paixao-Cavalcante, D.; Fish, J.; Manderson, A.P.; Malik, T.H.; Bygrave, A.E.; Lin, T.; Sacks, S.H.; Walport, M.J.; Cook, H.T.; Botto, M.; Pickering, M.C.
Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
J. Clin. Invest.
118
608-618
2008
Mus musculus (Q61129)
Manually annotated by BRENDA team
Nilsson, S.C.; Karpman, D.; Vaziri-Sani, F.; Kristoffersson, A.C.; Salomon, R.; Provot, F.; Fremeaux-Bacchi, V.; Trouw, L.A.; Blom, A.M.
A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation
Mol. Immunol.
44
1835-1844
2007
Homo sapiens (P05156)
Manually annotated by BRENDA team
Timar, K.K.; Junnikkala, S.; Dallos, A.; Jarva, H.; Bhuiyan, Z.A.; Meri, S.; Bos, J.D.; Asghar, S.S.
Human keratinocytes produce the complement inhibitor factor I: Synthesis is regulated by interferon-gamma
Mol. Immunol.
44
2943-2949
2007
Homo sapiens (P05156), Homo sapiens
Manually annotated by BRENDA team
Okroj, M.; Hsu, Y.F.; Ajona, D.; Pio, R.; Blom, A.M.
Non-small cell lung cancer cells produce a functional set of complement factor I and its soluble cofactors
Mol. Immunol.
45
169-179
2008
Homo sapiens (P05156)
Manually annotated by BRENDA team
Kavanagh, D.; Richards, A.; Noris, M.; Hauhart, R.; Liszewski, M.K.; Karpman, D.; Goodship, J.A.; Fremeaux-Bacchi, V.; Remuzzi, G.; Goodship, T.H.; Atkinson, J.P.
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome
Mol. Immunol.
45
95-105
2008
Homo sapiens (P05156)
Manually annotated by BRENDA team
Chan, M.R.; Thomas, C.P.; Torrealba, J.R.; Djamali, A.; Fernandez, L.A.; Nishimura, C.J.; Smith, R.J.; Samaniego, M.D.
Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient
Am. J. Kidney Dis.
53
321-326
2009
Homo sapiens
Manually annotated by BRENDA team
Fagerness, J.A.; Maller, J.B.; Neale, B.M.; Reynolds, R.C.; Daly, M.J.; Seddon, J.M.
Variation near complement factor I is associated with risk of advanced AMD
Eur. J. Hum. Genet.
17
100-104
2009
Homo sapiens
Manually annotated by BRENDA team
Nilsson, S.C.; Trouw, L.A.; Renault, N.; Miteva, M.A.; Genel, F.; Zelazko, M.; Marquart, H.; Muller, K.; Sjoeholm, A.G.; Truedsson, L.; Villoutreix, B.O.; Blom, A.M.
Genetic, molecular and functional analyses of complement factor I deficiency
Eur. J. Immunol.
39
310-323
2009
Homo sapiens
Manually annotated by BRENDA team
Yuasa, I.; Nakagawa, M.; Umetsu, K.; Harihara, S.; Matsusue, A.; Nishimukai, H.; Fukumori, Y.; Saitou, N.; Park, K.S.; Jin, F.; Lucotte, G.; Chattopadhyay, P.K.; Henke, L.; Henke, J.
Molecular basis of complement factor I (CFI) polymorphism: one of two polymorphic suballeles responsible for CFI A is Japanese-specific
J. Hum. Genet.
53
1016-1021
2008
Homo sapiens
Manually annotated by BRENDA team
Wang, J.; Ohno-Matsui, K.; Yoshida, T.; Kojima, A.; Shimada, N.; Nakahama, K.; Safranova, O.; Iwata, N.; Saido, T.C.; Mochizuki, M.; Morita, I.
Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen
J. Immunol.
181
712-720
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Hair, P.S.; Ward, M.D.; Semmes, O.J.; Foster, T.J.; Cunnion, K.M.
Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b
J. Infect. Dis.
198
125-133
2008
Homo sapiens
Manually annotated by BRENDA team
Ponce-Castro, I.M.; Gonzalez-Rubio, C.; Delgado-Cervino, E.M.; Abarrategui-Garrido, C.; Fontan, G.; Sanchez-Corral, P.; Lopez-Trascasa, M.
Molecular characterization of Complement Factor I deficiency in two Spanish families
Mol. Immunol.
45
2764-2771
2008
Homo sapiens
Manually annotated by BRENDA team
Nakahata, K.; Matsunami, K.; Kobayashi, C.; Omori, T.; Xu, H.; Firdawes, S.; Fukuzawa, M.; Miyagawa, S.
Analysis of the serine protease function of porcine factor I produced by liver cells for xenotransplantation
Transpl. Immunol.
19
30-36
2008
Sus scrofa, Homo sapiens (P05156), Homo sapiens
Manually annotated by BRENDA team
Nilsson, S.C.; Kalchishkova, N.; Trouw, L.A.; Fremeaux-Bacchi, V.; Villoutreix, B.O.; Blom, A.M.
Mutations in complement factor I as found in atypical hemolytic uremic syndrome lead to either altered secretion or altered function of factor I
Eur. J. Immunol.
40
172-185
2010
Homo sapiens
Manually annotated by BRENDA team
Abernathy, J.W.; Lu, J.; Liu, H.; Kucuktas, H.; Liu, Z.
Molecular characterization of complement factor I reveals constitutive expression in channel catfish
Fish Shellfish Immunol.
27
529-534
2009
Ictalurus punctatus (C9D6Z5), Ictalurus punctatus
Manually annotated by BRENDA team
Hair, P.S.; Echague, C.G.; Sholl, A.M.; Watkins, J.A.; Geoghegan, J.A.; Foster, T.J.; Cunnion, K.M.
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosis
Infect. Immun.
78
1717-1727
2010
Homo sapiens
Manually annotated by BRENDA team
Shin, D.H.; Webb, B.M.; Nakao, M.; Smith, S.L.
Characterization of shark complement factor I gene(s): genomic analysis of a novel shark-specific sequence
Mol. Immunol.
46
2299-2308
2009
Ginglymostoma cirratum (B0LCZ7), Ginglymostoma cirratum (B0LCZ8), Ginglymostoma cirratum (B0LCZ9), Ginglymostoma cirratum (B0LD00), Ginglymostoma cirratum
Manually annotated by BRENDA team
Ennis, S.; Gibson, J.; Cree, A.; Collins, A.; Lotery, A.
Support for the involvement of complement factor I in age-related macular degeneration
Eur. J. Hum. Genet.
18
15-16
2010
Homo sapiens
Manually annotated by BRENDA team
Anastasiou, V.; Mikrou, A.; Papanastasiou, A.; Zarkadis, I.
The molecular identification of factor H and factor I molecules in rainbow trout provides insights into complement C3 regulation
Fish Shellfish Immunol.
31
491-499
2011
Oncorhynchus mykiss (E7BAR3), Oncorhynchus mykiss
Manually annotated by BRENDA team
Roversi, P.; Johnson, S.; Caesar, J.J.; McLean, F.; Leath, K.J.; Tsiftsoglou, S.A.; Morgan, B.P.; Harris, C.L.; Sim, R.B.; Lea, S.M.
Structural basis for complement factor I control and its disease-associated sequence polymorphisms
Proc. Natl. Acad. Sci. USA
108
12839-12844
2011
Homo sapiens
Manually annotated by BRENDA team
Sanchez-Gallego, J.I.; Groeneveld, T.W.; Krentz, S.; Nilsson, S.C.; Villoutreix, B.O.; Blom, A.M.
Analysis of binding sites on complement factor I using artificial N-linked glycosylation
J. Biol. Chem.
287
13572-13583
2012
Homo sapiens
Manually annotated by BRENDA team
Broderick, L.; Gandhi, C.; Mueller, J.L.; Putnam, C.D.; Shayan, K.; Giclas, P.C.; Peterson, K.S.; Aceves, S.S.; Sheets, R.M.; Peterson, B.M.; Newbury, R.O.; Hoffman, H.M.; Bastian, J.F.
Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis
J. Clin. Immunol.
33
162-171
2013
Homo sapiens
Manually annotated by BRENDA team
Johnson, J.; Borisevich, V.; Rockx, B.; Parks, G.
A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b
J. Virol.
89
989-998
2015
Nipah henipavirus
Manually annotated by BRENDA team
Malm, S.; Jusko, M.; Eick, S.; Potempa, J.; Riesbeck, K.; Blom, A.M.
Acquisition of complement inhibitor serine protease factor I and its cofactors C4b-binding protein and factor H by Prevotella intermedia
PLoS ONE
7
e34852
2012
Homo sapiens
Manually annotated by BRENDA team
Okroj, M.; Holmquist, E.; Nilsson, E.; Anagnostaki, L.; Jirstroem, K.; Blom, A.M.
Local expression of complement factor I in breast cancer cells correlates with poor survival and recurrence
Cancer Immunol. Immunother.
64
467-478
2015
Homo sapiens
Manually annotated by BRENDA team
Xiang, J.; Li, X.; Chen, Y.; Lu, Y.; Yu, M.; Chen, X.; Zhang, W.; Zeng, Y.; Sun, L.; Chen, S.; Sha, Z.
Complement factor I from flatfish half-smooth tongue (Cynoglossus semilaevis) exhibited anti-microbial activities
Dev. Comp. Immunol.
53
199-209
2015
Cynoglossus semilaevis (A0A0H4CX09), Cynoglossus semilaevis
Manually annotated by BRENDA team
Kumar, J.; Yadav, V.; Phulera, S.; Kamble, A.; Gautam, A.; Panwar, H.; Sahu, A.
Species specificity of vaccinia virus complement control protein for the bovine classical pathway is governed primarily by direct interaction of its acidic residues with factor I
J. Virol.
91
e00668-17
2017
Bos taurus, Homo sapiens
Manually annotated by BRENDA team