3.4.21.45: complement factor I
This is an abbreviated version!
For detailed information about complement factor I, go to the full flat file.
Word Map on EC 3.4.21.45
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3.4.21.45
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hemolytic
-
convertase
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macular
-
properdin
-
uremic
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cell-bound
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c3d
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fluid-phase
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glomerulonephritis
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complement-mediated
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opsonization
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medicine
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i-mediated
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eculizumab
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alpha\'-chain
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c4-binding
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c4bp
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microangiopathic
-
opsonin
- 3.4.21.45
-
hemolytic
-
convertase
-
macular
- properdin
-
uremic
-
cell-bound
- c3d
-
fluid-phase
- glomerulonephritis
-
complement-mediated
-
opsonization
- medicine
-
i-mediated
- eculizumab
-
alpha\'-chain
-
c4-binding
- c4bp
-
microangiopathic
-
opsonin
Reaction
Inactivates complement subcomponents C3b, iC3b and C4b by proteolytic cleavage =
Synonyms
C3b inactivator, C3b/C4b inactivator, C3bINA, CFI, complement C3b inactivator, complement C3b/C4b inactivator, complement C4b inactivator, complement C4bi, complement compoment C3b inactivator, complement factor I, complement inhibitor factor I, complement regulator factor I, conglutinogen-activating factor C, factor I, factor I-like activity, fI, GcIf-1, GcIf-2, GcIf-3, GcIf-4, IF, plasma protease factor I, serine protease Factor I
ECTree
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KM Value
KM Value on EC 3.4.21.45 - complement factor I
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0.027
N-alpha-tert-butyloxycarbonyl-Val-Pro-Arg-4-methylcoumaryl-7-amide
-
pH 8.3, 37°C
0.0146
tert-butyloxycarbonyl-Asp(benzyl ester)-Pro-Arg-4-methylcoumaryl-7-amide
-
pH 8.3, 37°C
0.041
-
mutant K182Q/R184Q, Vmax: 0.058 pmol/min/microgram protein
0.0508
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant M220A/K221Q, Vmax: 0.01 pmol/min/microgram protein
0.054
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant K51A/R62A/L73A/L76A/F82A, Vmax: 0.085 pmol/min/microgram protein
0.074
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant K93Q/F94A, Vmax: 0.147 pmol/min/microgram protein
0.083
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant L73A/L76A/F82A, Vmax: 0.053 pmol/min/microgram protein
0.103
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant R130Q/R169Q, Vmax: 0.16 pmol/min/microgram protein
0.112
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant K124Q/R150Q/F151A/K152Q, Vmax: 0.1 pmol/min/microgram protein
0.114
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant D207N/Q219A, Vmax: 0.044 pmol/min/microgram protein
0.121
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant V252A/I267A, Vmax: 1.284 pmol/min/microgram protein
0.122
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant R150Q/F151A/K152Q, Vmax: 0.087 pmol/min/microgram protein
0.14
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant D26N/K27Q/F29A/Q31A, Vmax: 0.834 pmol/min/microgram protein
0.149
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
wild-type, Vmax: 0.09 pmol/min/microgram protein
0.168
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant F94A/K182Q/R184Q, Vmax: 0.672 pmol/min/microgram protein
0.177
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant K51A/R62A, Vmax: 0.373 pmol/min/microgram protein
0.195
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant D207N/Q219A/M220A/K221Q, Vmax: 0.032 pmol/min/microgram protein
0.199
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant F29A/Q31A, Vmax: 0.854 pmol/min/microgram protein
0.203
tert-butyloxycarbonyl-Asp(benzyl)-Pro-Arg-7-amido-4-methylcoumarin
-
mutant V212A/L236A, Vmax: 2.126 pmol/min/microgram protein