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0.0001
(2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid
pH 8.1, 37°C
0.0000247 - 0.000122
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
0.0003 - 0.0009
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
0.00000015
acyclic SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.000003
Apios Americana trypsin inhibitor
-
-
-
0.0004
AVNIPFKVHFRCKAAFC
-
in 50 mM Tris-HCl, pH 7.8, at 37°C
0.0027 - 0.197
benzamidine
0.0018
bis(m-amidinosalicylidene-L-alaninato)iron(III)
-
-
0.0016
bis(p-amidinosalicylidene-L-alaninato)iron(III)
-
-
-
0.0000029
Bovine pancreatic trypsin inhibitor
-
recombinant inhibitor from Pichia pastoris, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, pH 7.5 containing 0.1% (w/v) bovine serum albumin, at 25°C
-
0.0000031
clispin
-
pH 8.0, 37°C
0.000000063
cMCoTI-II
-
pH not specified in the publication, temperature not specified in the publication
-
0.00000008
cyclic SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.0000003
DOTA-SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.000013
Kunitz domain 1 of tissue factor pathway inhibitor-2
-
-
-
0.000849
LEKTI
-
pH 7.4, 25°C
0.000031
leupeptin
-
in 10 mM Tris, 20 mM CaCl2, pH 7.4, at 37°C
0.0028
m-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
0.000044
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-acetyl-piperazide
-
-
0.000042
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-methylpiperidide
-
-
0.00066
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid
-
-
0.0011
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid methyl ester
-
-
0.00022
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid
-
-
0.000021
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid methylester
-
-
0.00012
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-piperazide
-
-
0.00000805 - 0.00871
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
0.03
napsagatran ethylester
-
-
0.00000043
oMCoTI-II
-
pH not specified in the publication, temperature not specified in the publication
-
0.0042
p-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
0.00004
Plathymenia foliolosa trypsin inhibitor
-
at 37°C, in Tris-HCl buffer (100 mM), pH 8.0
-
0.000000014
Putranjiva roxburghii trypsin inhibitor
-
in 50 mM Tris-HCl buffer, pH 8.0 containing 20 mM CaCl2 and 0.001 N HCl, at 30°C
-
0.0023
Spinacia oleracea trypsin inhibitor
-
in 0.1 M Tris_HCl (pH 8.0) at 37°C
-
0.0000188
SVIGCWTKSIPPRPCFVK-amide
-
in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C
0.0000542
SVIGCWTRSIPPRPCFVK-amide
-
in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C
0.0003098
Vigna mungo trypsin inhibitor
-
pH 8.2, 37°C
-
0.0023 - 0.0134
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
0.00605 - 0.0445
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
0.00001
[Arg5]-SFTI-1
-
pH 8.1, 37°C
0.0000001
[Lys5]-SFTI-1
-
pH 8.1, 37°C
0.00022
[Phe5]-SFTI-1
-
pH 8.1, 37°C
additional information
additional information
-
0.0000247
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
-
variant X(99/175/190)rT containing the 99-loop the 175-loop (Ser172, Ser173, Phe174, Ile175) and Ala190 of factor Xa
0.000054
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
-
variant X99rT containing the 99-loop (Glu97,Tyr99) of factor Xa
0.000122
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
-
native enzyme
0.0003
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
-
pH 8.0, mutant enzyme S190A
0.0004
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
-
pH 8.0, wild-type enzyme
0.0007
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
-
pH 8.0, mutant enzyme E97N/Y99L
0.0009
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
-
pH 8.0, mutant enzyme E97N/Y99L/S190A
0.0027
benzamidine
pH 7.6, recombinant enzyme
0.0048
benzamidine
pH 7.6, mutant enzyme T190S
0.00651
benzamidine
-
native enzyme
0.0099
benzamidine
pH 7.6, mutant enzyme T190A
0.0164
benzamidine
pH 7.6, mutant enzyme T190P
0.0322
benzamidine
-
variant X99rT containing the 99-loop (Glu97, Tyr99) of factor Xa
0.034
benzamidine
-
pH 8.0, mutant enzyme S190A
0.036
benzamidine
-
pH 8.0, mutant enzyme E97N/Y99L
0.039
benzamidine
-
pH 8.0, wild-type enzyme
0.053
benzamidine
-
pH 8.0, mutant enzyme E97N/Y99L/S190A
0.143
benzamidine
-
variant X(99/175/190)rT containing the 99-loop the 175-loop (Ser172,Ser173, Phe174, Ile175) and Ala190 of factor Xa
0.197
benzamidine
pH 7.6, mutant enzyme T190V
0.00000805
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
-
native enzyme
0.00152
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
-
variant X99rT containing the 99-loop (Glu97, Tyr99) of factor Xa
0.00871
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
-
variant X(99/175/190)rT containing the 99-loop the 175-loop (Ser172, Ser173, Phe174, Ile175) and Ala190 of factor Xa
0.0023
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
-
pH 8.0, mutant enzyme E97N/Y99L
0.0067
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
-
pH 8.0, mutant enzyme E97N/Y99L/S190A
0.008
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
-
pH 8.0, mutant enzyme S190A
0.0134
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
-
pH 8.0, wild-type enzyme
0.00605
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
-
variant X(99/175/190)rT containing the 99-loop the 175-loop (Ser172, Ser173, Phe174, Ile175) and Ala190 of factor Xa
0.0256
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
-
native enzyme
0.0445
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
-
variant X99rT containing the 99-loop (Glu97,Tyr99) of factor Xa
additional information
additional information
-
enzyme inhibition kinetic analysis of wild-type inhibitor and mutants, Lys33GP, Lys33K/F, and Lys16 peptide, overview
-
additional information
additional information
-
Glycine max trypsin inhibitor inhibition kinetics, overview
-
additional information
additional information
-
pseudo-first-order inhibition kinetics for trypsin, overview
-