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3.4.21.4: trypsin

This is an abbreviated version!
For detailed information about trypsin, go to the full flat file.

Word Map on EC 3.4.21.4

Reaction

preferential cleavage: Arg-/-, Lys-/- =

Synonyms

acrosin, alpha-trypsin, anionic salmon trypsin, anionic trypsin, Anionic trypsinogen, AST, aT-I, aT-II, Atlantic cod trypsin I, beta-trypsin, BPT, Brain trypsinogen, BT, cationic trypsin, Cationic trypsinogen, cocoonase, CST, EC 3.4.4.4, EFE, EG-T, fibrinolytic enzyme, gamma-trypsin, GM-T, group III trypsin, mesotrypsin, Mesotrypsinogen, midgut-specific serine protease 1, midgut-specific serine protease 2, More, p23, parenzyme, parenzymol, PPT, pro23, pseudotrypsin, SET, SGT, sperm receptor hydrolase, ST-1, ST-2, ST-3, TI, TIIA, TIII, TLE, TLE I, TLE II, TR-P, TR-S, tripcellim, TRP, Try, TRY-3, TryI, TryII, TryIII, TRYP, trypsin 1, trypsin 3A1, trypsin 4, trypsin A, trypsin B, trypsin I, trypsin IV, trypsin type III, trypsin Y, trypsin-1, trypsin-2, trypsin-3, trypsin-4, trypsin-like enzyme, trypsin-like serine proteinase, tryptar, tryptase, trypure, TrypZean, type I trypsin, type IX pancreatic trypsin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.4 trypsin

KI Value

KI Value on EC 3.4.21.4 - trypsin

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0001
(2R,4R)-4-phenyl-1-[Nalpha-(7-methoxy-2-naphthalenesulfonyl)-L-arginyl]-2-piperidinecarboxylic acid
pH 8.1, 37°C
0.0000247 - 0.000122
2,7-bis(4-amidinobenzylidene)-cycloheptan-1-one
0.0003 - 0.0009
2,7-bis(4-amidinobenzylidene)cycloheptan-1-one
0.00000015
acyclic SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.000003
Apios Americana trypsin inhibitor
-
-
-
0.0004
AVNIPFKVHFRCKAAFC
-
in 50 mM Tris-HCl, pH 7.8, at 37°C
0.0027 - 0.197
benzamidine
0.0018
bis(m-amidinosalicylidene-L-alaninato)iron(III)
-
-
0.0016
bis(p-amidinosalicylidene-L-alaninato)iron(III)
-
-
-
0.0000029
Bovine pancreatic trypsin inhibitor
-
recombinant inhibitor from Pichia pastoris, in 50 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, pH 7.5 containing 0.1% (w/v) bovine serum albumin, at 25°C
-
0.0000031
clispin
-
pH 8.0, 37°C
0.000000063
cMCoTI-II
-
pH not specified in the publication, temperature not specified in the publication
-
0.00041
CRC 220
-
-
0.00000008
cyclic SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.0000017
DMTI-II
-
-
-
0.0000003
DOTA-SFTI
-
pH not specified in the publication, temperature not specified in the publication
0.000013
Kunitz domain 1 of tissue factor pathway inhibitor-2
-
-
-
0.000849
LEKTI
-
pH 7.4, 25°C
0.000031
leupeptin
-
in 10 mM Tris, 20 mM CaCl2, pH 7.4, at 37°C
0.0028
m-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
0.026
Nafamostat
-
-
0.000044
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-acetyl-piperazide
-
-
0.000042
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-4'-methylpiperidide
-
-
0.00066
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid
-
-
0.0011
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-D-pipecolic acid methyl ester
-
-
0.00022
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid
-
-
0.000021
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-isopecotinic acid methylester
-
-
0.00012
Nalpha-(2-naphthylsulfonyl)-L-3-amidino-phenylalanine-piperazide
-
-
0.00000805 - 0.00871
Nalpha-tosylglycyl-3-amidino-DL-phenylalanine-methyl ester
0.0116
napsagatran
-
-
0.03
napsagatran ethylester
-
-
0.00000043
oMCoTI-II
-
pH not specified in the publication, temperature not specified in the publication
-
0.0042
p-amidinosalicylidene-L-alaninato(aqua)copper(II)
-
-
0.00004
Plathymenia foliolosa trypsin inhibitor
-
at 37°C, in Tris-HCl buffer (100 mM), pH 8.0
-
0.000000014
Putranjiva roxburghii trypsin inhibitor
-
in 50 mM Tris-HCl buffer, pH 8.0 containing 20 mM CaCl2 and 0.001 N HCl, at 30°C
-
0.0023
Spinacia oleracea trypsin inhibitor
-
in 0.1 M Tris_HCl (pH 8.0) at 37°C
-
0.0000188
SVIGCWTKSIPPRPCFVK-amide
-
in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C
0.0000542
SVIGCWTRSIPPRPCFVK-amide
-
in 10 mM phosphate buffer, pH 7.4, containing 2.7 mM KCl and 137 mM NaCl, at 37°C
0.0003098
Vigna mungo trypsin inhibitor
-
pH 8.2, 37°C
-
0.0023 - 0.0134
[4-(6-chloro-naphthalene-2-sulfonyl)-piperazin-1-yl]-(3,4,5-6-tetrahydro-[2H-1,4']bipyridinyl-4yl)-methanone
0.00605 - 0.0445
[4-(6-chloro-naphthalene-2-sulphonyl)piperazin-1-yl]-(3,4,5,6-tetrahydro-[2H-1,4']bipyridinyl-4-yl)-methanone
0.00001
[Arg5]-SFTI-1
-
pH 8.1, 37°C
0.0000001
[Lys5]-SFTI-1
-
pH 8.1, 37°C
0.00022
[Phe5]-SFTI-1
-
pH 8.1, 37°C
additional information
additional information
-