3.4.21.21: coagulation factor VIIa

This is an abbreviated version!
For detailed information about coagulation factor VIIa, go to the full flat file.

Reaction

Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =

Synonyms

activated blood coagulation factor VII, activated coagulation factor VII, activated factor VII, blood coagulation factor VIIa, blood-coagulation factor VII, activated, blood-coagulation factor VIIa, coagulation factor VII, coagulation factor VII(a), coagulation FVII, Eptacog alfa, Factor VII, factor VIIa, factor VIIa-sTF, factor VIIa-TF, factor VIIa/tissue factor complex, FIIa, free factor VIIa, FVII, FVIIa, FVIIa-sTF, fVIIa/TF, FVIIc, human factor VIIa + TF, More, NovoSeven, procoagulant protein factor VII, recombinant factor VIIa, recombinant factor-activated VII, rFVII, rFVIIa, serine protease factor VIIa, Serum prothrombin conversion accelerator, soluble tissue factor/factor VIIa complex, sTF/VIIa, TF-FVIIa, TF/VIIa, tissue factor/factor VIIa, tissue factor/factor VIIa complex, vitamin K dependent clotting factor

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.21 coagulation factor VIIa

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Results	in table
38	Activating Compound
639	AA Sequence
14	Application
1	CAS Registry Number
15	Cloned(Commentary)
3	Cofactor
12	Crystallization (Commentary)
16055	Disease/ Diagnostics
2	Expression
15	General Information
151	IC50 Value
231	Inhibitors
8	kcat/KM [mM/s]
55	Ki Value [mM]
100	KM Value [mM]
10	Localization
16	Metals/Ions
7	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
106	Organism
199	PDB ID
3	pH Optimum
17	Posttranslational Modification
87	Protein Variants
16	Purification (Commentary)
1	Reaction
2	Reaction Type
106	Reference
28	Source Tissue
4	Specific Activity [micromol/min/mg]
135	Substrates and Products (Substrate)
6	Subunits
130	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
89	Turnover Number [1/s]

Temperature Stability

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Temperature Stability on EC 3.4.21.21 - coagulation factor VIIa

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

58

Homo sapiens

-

heat inactivation is fully reversible up to 15 min

95332

60

Homo sapiens

-

the melting temperature of the recombinant enzyme is at about 60°C. GlycoPEGylation delays the thermally induced aggregation, and slightly increases the unfolding temperature of the protein from 57.7°C to 59°C

717686