3.4.21.21: coagulation factor VIIa

This is an abbreviated version!
For detailed information about coagulation factor VIIa, go to the full flat file.

Word Map on EC 3.4.21.21

3.4.21.21

bleeding

fibrinogen

platelet

viii

hemostatic

hemorrhage

thrombosis

anticoagulant

thromboplastin

plasminogen

haemophilia

antithrombin

coagulopathy

coronary

transfusion

willebrand

thromboembolic

trauma

fibrin

fibrinolysis

haemostasis

d-dimers

antithrombotic

warfarin

hypercoagulable

intravascular

pai-1

off-label

perioperative

hematoma

k-dependent

amidolytic

thrombogenic

antifibrinolytic

tranexamic

prothrombotic

thrombin-antithrombin

plasma-derived

drug development

prothrombinase

epistaxis

fondaparinux

desmopressin

cryoprecipitate

thromboelastometry

dabigatran

biotechnology

gamma-carboxyglutamic

menorrhagia

apixaban

thromboelastography

bethesda

medicine

Reaction

Selective cleavage of Arg-/-Ile bond in factor X to form factor Xa =

Synonyms

activated blood coagulation factor VII, activated coagulation factor VII, activated factor VII, blood coagulation factor VIIa, blood-coagulation factor VII, activated, blood-coagulation factor VIIa, coagulation factor VII, coagulation factor VII(a), coagulation FVII, Eptacog alfa, Factor VII, factor VIIa, factor VIIa-sTF, factor VIIa-TF, factor VIIa/tissue factor complex, FIIa, free factor VIIa, FVII, FVIIa, FVIIa-sTF, fVIIa/TF, FVIIc, human factor VIIa + TF, More, NovoSeven, procoagulant protein factor VII, recombinant factor VIIa, recombinant factor-activated VII, rFVII, rFVIIa, serine protease factor VIIa, Serum prothrombin conversion accelerator, soluble tissue factor/factor VIIa complex, sTF/VIIa, TF-FVIIa, TF/VIIa, tissue factor/factor VIIa, tissue factor/factor VIIa complex, vitamin K dependent clotting factor

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.21 coagulation factor VIIa

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Results	in table
38	Activating Compound
639	AA Sequence
14	Application
1	CAS Registry Number
15	Cloned(Commentary)
3	Cofactor
12	Crystallization (Commentary)
16055	Disease/ Diagnostics
2	Expression
15	General Information
151	IC50 Value
231	Inhibitors
8	kcat/KM [mM/s]
55	Ki Value [mM]
100	KM Value [mM]
10	Localization
16	Metals/Ions
7	Molecular Weight [Da]
48	Natural Substrates/ Products (Substrates)
106	Organism
199	PDB ID
3	pH Optimum
17	Posttranslational Modification
87	Protein Variants
16	Purification (Commentary)
1	Reaction
2	Reaction Type
106	Reference
28	Source Tissue
4	Specific Activity [micromol/min/mg]
135	Substrates and Products (Substrate)
6	Subunits
130	Synonyms
5	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
89	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 3.4.21.21 - coagulation factor VIIa

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45530

Homo sapiens

fully de-N-glycosylated protein, studied by MALDI-TOF mass spectrometry

692535

46070

Homo sapiens

calculated from the amino acid sequence and considering 12 disulfide bridges

692535

50000

2 entries

50100

Homo sapiens

native FVIIa, studied by MALDI-TOF mass spectrometry

692535

55000

Homo sapiens

P08709

SDS-PAGE, recombinant fusion protein

707826

additional information

Homo sapiens

the zymogen, factor VII, is composed of a single polypeptide chain polypeptide of 48000 Da, with the NH2-terminal sequence Ala-Asn-Ala-Phe-Leu-(gamma-carboxyglutamic acid)-(gamma-carboxyglutamic acid)-Leu-Arg-Pro. It is converted to a two-chain form, factor VIIa, connected by disulfide bonds by the action of factor Xa, in the presence of phospholipids and calcium and by factor XIIa, without additional cofactors

95327