3.4.21.20: cathepsin G

This is an abbreviated version!
For detailed information about cathepsin G, go to the full flat file.

Word Map on EC 3.4.21.20

3.4.21.20

elastase

neutrophil

leukocyte

proteinases

granule

polymorphonuclear

myeloperoxidase

chymase

granulocyte

thrombin

platelet

mast

azurophilic

serpins

plasmin

lactoferrin

collagenase

neutrophil-derived

granzyme

kallikrein

1-proteinase

degranulation

tryptase

antineutrophil

1-antichymotrypsin

eglin

drug development

nsp4

antiproteinases

2-macroglobulin

fmlp

hne

alpha-chymotrypsin

wegener

chediak-higashi

antiprotease

elastolytic

chymostatin

slpi

elastase-like

p-anca

procollagenase

alpha1-proteinase

pharmacology

pmn-derived

elafin

1-antitrypsin

medicine

granulomatosis

alpha1-antichymotrypsin

anti-cathepsin

neutrophil-mediated

anca-positive

Reaction

specificity similar to chymotrypsin C =

Synonyms

alpha-protease, cat G, Cat-G, Cat.G, CatG, Cath G, cathepsin G, chymotrypsin-like proteinase, CTSG, More, neutral proteinase, serine protease cathepsin G, Vimentin-specific protease, VSP

ECTree

3.4 Acting on peptide bonds (peptidases)

3.4.21 Serine endopeptidases

3.4.21.20 cathepsin G

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Results	in table
5	Activating Compound
8	AA Sequence
7	Application
1	CAS Registry Number
2	Cloned(Commentary)
2	Crystallization (Commentary)
1068	Disease/ Diagnostics
8	Expression
22	General Information
2	General Stability
166	Inhibitors
27	kcat/KM [mM/s]
24	Ki Value [mM]
25	KM Value [mM]
29	Localization
4	Metals/Ions
15	Molecular Weight [Da]
73	Natural Substrates/ Products (Substrates)
160	Organism
9	PDB ID
16	pH Optimum
3	pH Range
2	pI Value
5	Posttranslational Modification
7	Protein Variants
17	Purification (Commentary)
2	Reaction
1	Reaction Type
105	Reference
140	Source Tissue
12	Specific Activity [micromol/min/mg]
2	Storage Stability
197	Substrates and Products (Substrate)
13	Subunits
46	Synonyms
16	Temperature Optimum [°C]
22	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.21.20 - cathepsin G

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0.0071

alpha-1 proteinase inhibitor

-

-

-

0.027

alpha-1-antichymotrypsin

-

-

-

0.0000008

dermatan sulfate

-

pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

0.000000015

ecotin

-

-

-

0.000003

heparan sulfate

-

pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

0.0000008

heparin

-

pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide

0.00172

heparin N

-

pH 7.4

-

0.00082

heparin S0

-

pH 7.4

-

0.00213

heparin S1

-

pH 7.4

-

0.00003

heparin S2

-

pH 7.4

-

0.00081

heparin S3

-

pH 7.4

-

0.000038

JNJ-10311795

-

0.27 - 2.48

Lys16-aprotinin

show

-

0.59

mutant R346F of plasminogen activator inhibitor-1

-

-

-

0.00000011

RG1150

-

pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-thiobenzyl ester

-

0.00000017

RG1192

show

-

0.0000012

RG1503

-

pH 7.4, 25°C, with substrate succinyl-Ala-Ala-Pro-Phe-4-nitroanilide, in presence of 0.1 Na+

-

0.00005 - 0.00006

[2-(3-[(piperidin-4-yl)-methyl-carbamoyl]-naphthalen-2-yl)1-naphthalen-1-yl-2-oxo-ethyl]-phosphonic acid

-

-

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Release 2023.1 (January 2023)