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3.4.21.20: cathepsin G

This is an abbreviated version!
For detailed information about cathepsin G, go to the full flat file.

Word Map on EC 3.4.21.20

Reaction

specificity similar to chymotrypsin C =

Synonyms

alpha-protease, cat G, Cat-G, Cat.G, CatG, Cath G, cathepsin G, chymotrypsin-like proteinase, CTSG, More, neutral proteinase, serine protease cathepsin G, Vimentin-specific protease, VSP

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.20 cathepsin G

Expression

Expression on EC 3.4.21.20 - cathepsin G

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
both CatG activity and transcript level are elevated in peripheral blood mononuclear cells from type 1 diabetes mellitus patients. Vitamin D reduces CatG activity only in myeloid dendritic cells from healthy donors
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higher expression of Cat-G in biopsies from patients with ulcerative colitis
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increased expression at the tumor-bone interface
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level of cathepsin G is reduced in peripheral polymorphonuclear leukocytes of hemodialysis patients, while the mRNA enzyme level is not different
patients with atherosclerosis have significantly reduced plasma enzyme levels
the enzyme expression and activity is increased in peripheral blood mononuclear cells and muscle tissues of dermatomyositis patients
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up-regulated at the tumor-bone interface
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