3.4.21.20: cathepsin G
This is an abbreviated version!
For detailed information about cathepsin G, go to the full flat file.
Word Map on EC 3.4.21.20
-
3.4.21.20
-
elastase
-
neutrophil
-
leukocyte
-
proteinases
-
granule
-
polymorphonuclear
-
myeloperoxidase
-
chymase
-
granulocyte
-
thrombin
-
platelet
-
mast
-
azurophilic
-
serpins
-
plasmin
-
lactoferrin
-
collagenase
-
neutrophil-derived
-
granzyme
-
kallikrein
-
1-proteinase
-
degranulation
-
tryptase
-
antineutrophil
-
1-antichymotrypsin
-
eglin
-
drug development
-
nsp4
-
antiproteinases
-
2-macroglobulin
-
fmlp
-
hne
-
alpha-chymotrypsin
-
wegener
-
chediak-higashi
-
antiprotease
-
elastolytic
-
chymostatin
-
slpi
-
elastase-like
-
p-anca
-
procollagenase
-
alpha1-proteinase
-
pharmacology
-
pmn-derived
-
elafin
-
1-antitrypsin
-
medicine
-
granulomatosis
-
alpha1-antichymotrypsin
-
anti-cathepsin
-
neutrophil-mediated
-
anca-positive
- 3.4.21.20
- elastase
- neutrophil
- leukocyte
- proteinases
- granule
-
polymorphonuclear
- myeloperoxidase
- chymase
- granulocyte
- thrombin
- platelet
-
mast
-
azurophilic
- serpins
- plasmin
- lactoferrin
- collagenase
-
neutrophil-derived
-
granzyme
- kallikrein
-
1-proteinase
-
degranulation
- tryptase
-
antineutrophil
-
1-antichymotrypsin
- eglin
- drug development
- nsp4
-
antiproteinases
-
2-macroglobulin
- fmlp
- hne
- alpha-chymotrypsin
-
wegener
-
chediak-higashi
-
antiprotease
-
elastolytic
- chymostatin
- slpi
-
elastase-like
-
p-anca
- procollagenase
- alpha1-proteinase
- pharmacology
-
pmn-derived
- elafin
-
1-antitrypsin
- medicine
-
granulomatosis
- alpha1-antichymotrypsin
-
anti-cathepsin
-
neutrophil-mediated
-
anca-positive
Reaction
specificity similar to chymotrypsin C =
Synonyms
alpha-protease, cat G, Cat-G, Cat.G, CatG, Cath G, cathepsin G, chymotrypsin-like proteinase, CTSG, More, neutral proteinase, serine protease cathepsin G, Vimentin-specific protease, VSP
ECTree
Advanced search results
Engineering
Engineering on EC 3.4.21.20 - cathepsin G
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
A226E
S189A/A226E
-
the mutant shows decreased catalytic efficiency compared to the wild type enzyme and develops Lys-thioesterase activity
additional information
A226E
the substitution at the bottom of the cathepsin G S1 pocket allows cathepsin G to accommodate a Lys residue at P1
A226E
-
the mutant of mouse cathepsin G acquires tryptic activity and human ability to activate prourokinase
-
acute inflammatory response components are decreased by more than 50% in kidneys from cathepsin G-deficient versus wild-type mice, ischemic kidneys from cathepsin G-deficient mice have a 70% decrease in tubular cell apoptosis with little detectable collagen deposition, phenotypes, overview
additional information
-
no increased cytokine production and increased bacterial reduction by phagocytosis in infected lungs of enzyme-deficient mice compared to wild-type mice, overview
additional information
-
when microglia are treated with interferon-gamma to mimic a T helper type 1-biased cytokine milieu in multiple sclerosis, CatG is drastically down-regulated resulting in significantly increased stability of myelin basic protein and a selective lack of CatG-derived proteolytic fragments