3.4.21.1: chymotrypsin

This is an abbreviated version!
For detailed information about chymotrypsin, go to the full flat file.

Reaction

Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/- =

Synonyms

4CHA, Alcalase, alpha chymar, alpha chymotrypsin, alpha-Chy, alpha-chymar ophth, alpha-chymotrypsin, alpha-chymotrypsin A, alpha-CT, avazyme, bovine alpha-chymotrypsin, caldecrin, cationic chymotrypsin, cellulomonadin, CHT, Chtp, Chtr1, Chtr2, Chtr3, Chtr4, ChTRP, CHY1, CHY20, chymar, chymotest, chymotrypsin, chymotrypsin A, chymotrypsin B, chymotrypsin C, chymotrypsin C1, chymotrypsin I, chymotrypsin II, chymotrypsin isoform Kh1, chymotrypsin isoform Kh2, chymotrypsin isoform Kh3, chymotrypsin-B, CTRA, Ctrb, EC 3.4.4.5, EC 3.4.4.6, enzeon, LBCP, lysosomal Bid cleavage protease, PEG-alpha-chymotrypsin, PEG-modified alpha-chymotrypsin, quimar, quimotrase, serine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.1 chymotrypsin

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Results	in table
24	Activating Compound
103	AA Sequence
19	Application
1	CAS Registry Number
7	Cloned(Commentary)
14	Crystallization (Commentary)
1998	Disease/ Diagnostics
5	General Information
11	General Stability
45	IC50 Value
335	Inhibitors
44	kcat/KM [mM/s]
115	Ki Value [mM]
189	KM Value [mM]
5	Localization
11	Metals/Ions
35	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
14	Organic Solvent Stability
199	Organism
245	PDB ID
31	pH Optimum
16	pH Range
17	pH Stability
10	pI Value
8	Posttranslational Modification
5	Protein Variants
32	Purification (Commentary)
2	Reaction
1	Reaction Type
172	Reference
113	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
250	Substrates and Products (Substrate)
19	Subunits
148	Synonyms
16	Temperature Optimum [°C]
11	Temperature Range [°C]
27	Temperature Stability [°C]
187	Turnover Number [1/s]

pH Range

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pH Range on EC 3.4.21.1 - chymotrypsin

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10

Pterygoplichthys disjunctivus

-

71% of maximum activity

731829

4 - 11

Sardinops caeruleus

-

low activity of chymotrypsin I and II at acidic pH (4-5), considerably activity at pH from 6 to 9 whilst chymotrypsin I shows the highest activity toward the alkaline pH (7-11)

708549

4 - 9

3 entries

4.5 - 9.8

Camelus dromedarius

-

approx. 1% of maximal activity at pH 4.5, approx. 5% of maximal activity at pH 9.8

653202

5 - 10

Sardinops sagax

-

retains more than 80% activity over the pH range 5-10

679953

5 - 7

Silurus glanis

-

chymotrypsin isoform Kh3

667239

5 - 9

Silurus glanis

-

chymotrypsin isoform Kh1

667239

6 - 9

Panulirus interruptus

-

pH 6.0: about 80% of maximal activity, pH 9.0: about 55% of maximal activity

754581

6 - 9.3

Bos taurus

-

pH 6.0: about 35% of maximal activity, pH 9.3: 40% of maximal activity

171870

6.5 - 9.5

Camelus bactrianus

-

about 30% of maximal activity at pH 6.5 and at pH 9.5

171873

7 - 10

Daphnia magna

-

-

668324

7.5

Pterygoplichthys disjunctivus

-

88% of maximum activity

731829

7.5 - 9.5

Sepia officinalis

-

more than 92% of maximum activity within

731841

additional information

Carassius auratus

-

optimal pH of chymotrypsin A and B are 7.5 and 8.0, respectively, at 37°C

708555

4 - 9

Bos taurus

-

low activity chymotrypsin I and II at acidic pH (4–5), considerably activity at pH from 6 to 9

708549

4 - 9

Dosidicus gigas

-

pH 4.0: about 50% of maximal activity, pH 9.0: about 60% of maximal activity

753641

4 - 9

Silurus glanis

-

chymotrypsin isoform Kh2

667239