3.4.21.1: chymotrypsin

This is an abbreviated version!
For detailed information about chymotrypsin, go to the full flat file.

Reaction

Preferential cleavage: Tyr-/-, Trp-/-, Phe-/-, Leu-/- =

Synonyms

4CHA, Alcalase, alpha chymar, alpha chymotrypsin, alpha-Chy, alpha-chymar ophth, alpha-chymotrypsin, alpha-chymotrypsin A, alpha-CT, avazyme, bovine alpha-chymotrypsin, caldecrin, cationic chymotrypsin, cellulomonadin, CHT, Chtp, Chtr1, Chtr2, Chtr3, Chtr4, ChTRP, CHY1, CHY20, chymar, chymotest, chymotrypsin, chymotrypsin A, chymotrypsin B, chymotrypsin C, chymotrypsin C1, chymotrypsin I, chymotrypsin II, chymotrypsin isoform Kh1, chymotrypsin isoform Kh2, chymotrypsin isoform Kh3, chymotrypsin-B, CTRA, Ctrb, EC 3.4.4.5, EC 3.4.4.6, enzeon, LBCP, lysosomal Bid cleavage protease, PEG-alpha-chymotrypsin, PEG-modified alpha-chymotrypsin, quimar, quimotrase, serine protease

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.1 chymotrypsin

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Results	in table
24	Activating Compound
103	AA Sequence
19	Application
1	CAS Registry Number
7	Cloned(Commentary)
14	Crystallization (Commentary)
1998	Disease/ Diagnostics
5	General Information
11	General Stability
45	IC50 Value
335	Inhibitors
44	kcat/KM [mM/s]
115	Ki Value [mM]
189	KM Value [mM]
5	Localization
11	Metals/Ions
35	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
14	Organic Solvent Stability
199	Organism
245	PDB ID
31	pH Optimum
16	pH Range
17	pH Stability
10	pI Value
8	Posttranslational Modification
5	Protein Variants
32	Purification (Commentary)
2	Reaction
1	Reaction Type
172	Reference
113	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
250	Substrates and Products (Substrate)
19	Subunits
148	Synonyms
16	Temperature Optimum [°C]
11	Temperature Range [°C]
27	Temperature Stability [°C]
187	Turnover Number [1/s]

Temperature Range

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Temperature Range on EC 3.4.21.1 - chymotrypsin

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TEMPERATURE RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10 - 50

Sardinops caeruleus

-

chymotrypsin I shows high activity in the range from 20°C to 50°C and chymotrypsin II from 10°C to 45°C

708549

20 - 45

Carassius auratus

-

chymotrypsin A at 20°C exhibits more than 60% of its maximum activity, which is much higher than chymotrypsin B (27%). Slight changes in activity for both enzymes at 37°C. Relative activities of the two enzymes decrease sharply at above 45°C

708555

20 - 62

Bos taurus

-

approx. 50% of maximal activity at 20°C, approx. 20% of maximal activity at 62°C

650666

35 - 65

Panulirus interruptus

-

35°C: about 40% of maximal activity, 45°C: about 85% of maximal activity, 65°C: about 25% of maximal activity

754581

37 - 40

Bos taurus

-

catalytic activity of the enzyme exponentially falls off after 40°C and is thought to be associated with the thermal denaturation of the protein, the kcat and KM values associated with the enzyme catalysis increase up to 40°C and then fall

693937

40

Sepia officinalis

-

66% of maximum activity

731841

45 - 70

Dosidicus gigas

-

45°C: about 35% of maximal activity, 70°C: about 75% of maximal activity

753641

5 - 45

Bos taurus

-

-

667609

50

Sepia officinalis

-

85% of maximum activity

731841

55 - 70

Bos taurus

-

-

708549

60

Sepia officinalis

-

86% of maximum activity

731841