3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.19 Omega peptidases

                3.4.19.3 pyroglutamyl-peptidase I

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Results	in table
19	Activating Compound
8134	AA Sequence
30	Application
1	CAS Registry Number
18	Cloned(Commentary)
8	Crystallization (Commentary)
125	Disease/ Diagnostics
9	General Stability
173	Inhibitors
7	Ki Value [mM]
89	KM Value [mM]
17	Localization
8	Metals/Ions
48	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
11	Organic Solvent Stability
127	Organism
1	Pathway
78	PDB ID
25	pH Optimum
7	pH Range
7	pH Stability
30	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
126	Reference
2	Renatured (Commentary)
74	Source Tissue
18	Specific Activity [micromol/min/mg]
13	Storage Stability
198	Substrates and Products (Substrate)
24	Subunits
92	Synonyms
10	Temperature Optimum [°C]
4	Temperature Range [°C]
29	Temperature Stability [°C]
45	Turnover Number [1/s]

pH Stability

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pH Stability on EC 3.4.19.3 - pyroglutamyl-peptidase I

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

10.5

Pyrococcus furiosus

O73944

at alkaline pH the mutant enzyme enzymes C142S/C188S/E192A, C142S/C188S/E192I, C142S/C188S/E192V and C142S/C188S/E192Q are more stable than cysteine-free mutant C142S/C188S

667733

2.4

Pyrococcus furiosus

O73944

at acidic pH the mutant enzymes C142S/C188S/E192A, C142S/C188S/E192I, C142S/C188S/E192V, C142S/C188S/E192D and C142S/C188S/E192Q are less stable than cysteine-free mutant C142S/C188S

667733

4 - 9.2

Bos taurus

-

rapid inactivation below pH 4.0 and above pH 9.2

95299

7 - 8

3 entries

7 - 8.2

Gallus gallus

-

stable

95283

7 - 8

Bacillus amyloliquefaciens

-

30°C, stable in presence of 5 mM EDTA and 2-mercaptoethanol

95290

7 - 8

Bacillus amyloliquefaciens

-

stable in presence of 5 mM EDTA and 5 mM 2-mercaptoethanol

95280

7 - 8

Gallus gallus

-

30°C, 30 min, stable in presence of 5 mM each of EDTA and 2-mercaptoethanol

95283