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3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.19.3

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.3 pyroglutamyl-peptidase I

Substrates Products

Substrates Products on EC 3.4.19.3 - pyroglutamyl-peptidase I

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-oxoimidazolidinyl-4-carbonyl-Gly-Ile + H2O
?
show the reaction diagram
-
-
-
-
?
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide + H2O
L-2-oxothiazolidine-4-carboxylic acid + ?
show the reaction diagram
5-pyrrolidone-2-carboxyl-His-Gly + H2O
?
show the reaction diagram
-
slight activity
-
-
?
5-pyrrolidone-2-carboxyl-His-Trp + H2O
?
show the reaction diagram
-
-
-
-
?
ACE inhibitor + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-Trp-
-
?
acid-thyroliberin + H2O
pyroglutamate + His-Pro
show the reaction diagram
bombesin + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-Arg-
-
?
bombesin + H2O
pyroglutamate + Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
show the reaction diagram
bradykinin potentiator + H2O
pyroglutamate + ?
show the reaction diagram
bradykinin potentiator B + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-Gly-
-
?
bradykinin-potentiating peptide B + H2O
?
show the reaction diagram
-
cleavage of the peptide bond adjacent to the pyroglutamic residue
-
-
?
ethyl L-pyroglutamate + H2O
L-pyroglutamate + ethanol
show the reaction diagram
Fibrinogen + H2O
?
show the reaction diagram
-
bovine fribrinogen
-
-
?
Glu(OMe)2-litorin + H2O
pyroglutamate + ?
show the reaction diagram
-
-
-
?
gonadotropin-releasing hormone + H2O
?
show the reaction diagram
hydrolyzed exclusively at the pyroglutamyl-/-Xaa bond
-
-
?
L-2-oxoimidazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxooxazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-ethanolamine + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate + H2O
?
show the reaction diagram
-
-
-
-
?
L-2-oxothiazolidine-4-carboxyl-L-Ala + H2O
?
show the reaction diagram
L-pyroglutamic acid 2-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
L-pyroglutamyl-aminoethylnitrate + H2O
?
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphthylamine
show the reaction diagram
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + 2-naphtylamine
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphthylamine
show the reaction diagram
L-pyroglutamyl-beta-naphthylamide + H2O
L-pyroglutamate + beta-naphtylamine
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-His-Pro-4-methylcoumarin 7-amide + H2O
L-pyroglutamate + His-Pro-4-methylcoumarin 7-amide
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-L-Ala + H2O
L-pyroglutamate + L-Ala
show the reaction diagram
L-pyroglutamyl-L-Ile + H2O
L-pyroglutamate + L-Ile
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-L-Thr + H2O
L-pyroglutamate + L-Thr
show the reaction diagram
-
-
-
-
?
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutamate + p-nitroaniline
show the reaction diagram
L-pyroglutamyl-p-nitroanilide + H2O
L-pyroglutaminic acid + p-nitroaniline
show the reaction diagram
-
-
-
?
L-pyrrolidonyl 2-naphthylamide + H2O
5-oxo-L-proline + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
leukopyrokinin + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-Thr-
-
?
litorin + H2O
pyroglutamate + Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
show the reaction diagram
luliberin + H2O
pyroglutamate + His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2
show the reaction diagram
luteinizing hormone releasing hormone + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-His-
-
?
luteinizing-hormone-releasing hormone + H2O
?
show the reaction diagram
N-(4-methyl-2-oxo-2H-chromen-7-yl)-5-oxo-L-prolinamide + H2O
5-oxo-L-proline + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
neurotensin + H2O
pyroglutamate + ?
show the reaction diagram
contains the N-terminal dipeptide pyroglutamyl-Leu-
-
?
neurotensin + H2O
pyroglutamate + Leu-Tyr-Glu-Asn-Lys-Pro-Ag-Arg-Pro-Tyr-Ile-Leu
show the reaction diagram
physalaemin + H2O
pyroglutamate + Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2
show the reaction diagram
pyroglutamic acid-7-amido-4-methylcoumarin + H2O
L-pyroglutamate + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
pyroglutamyl-2-naphthylamide + H2O
pyroglutamate + 2-naphthylamine
show the reaction diagram
-
-
-
-
?
pyroglutamyl-4-methylcoumarin 7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
show the reaction diagram
pyroglutamyl-4-methylcoumaryl-7-amide + H2O
pyroglutamate + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
?
pyroglutamyl-4-methylumbelliferyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Ala + H2O
pyroglutamate + Ala
show the reaction diagram
pyroglutamyl-Arg + H2O
pyroglutamate + Arg
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Asp + H2O
pyroglutamate + Asp
show the reaction diagram
-
-
-
-
?
pyroglutamyl-beta-naphthylamide + H2O
pyroglutamate + beta-naphthylamine
show the reaction diagram
pyroglutamyl-D-Ala + H2O
pyroglutamate + D-Ala
show the reaction diagram
pyroglutamyl-D-Leu + H2O
pyroglutamate + D-Leu
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Glu + H2O
pyroglutamate + Glu
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Gly + H2O
pyroglutamate + Gly
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Gly-Ile + H2O
pyroglutamate + Gly-Ile
show the reaction diagram
-
-
-
-
?
pyroglutamyl-His + H2O
pyroglutamate + His
show the reaction diagram
-
-
-
-
?
pyroglutamyl-His-Gly + H2O
pyroglutamate + His-Gly
show the reaction diagram
pyroglutamyl-His-Gly-NH2 + H2O
pyroglutamate + His-Gly-NH2
show the reaction diagram
pyroglutamyl-His-Pro-Gly + H2O
pyroglutamate + His-Pro-Gly
show the reaction diagram
-
-
-
-
?
pyroglutamyl-His-Pro-Gly-NH2 + H2O
pyroglutamate + His-Pro-Gly-NH2
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Ile + H2O
pyroglutamate + Ile
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Leu + H2O
pyroglutamate + Leu
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Lys + H2O
pyroglutamate + Lys
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Met + H2O
pyroglutamate + Met
show the reaction diagram
-
-
-
-
?
pyroglutamyl-p-nitroanilide + H2O
pyroglutamate + p-nitroaniline
show the reaction diagram
pyroglutamyl-peptide + H2O
pyroglutamate + peptide
show the reaction diagram
-
the enzyme is able to specifically remove the amino-terminal pyroglutamyl residue protecting proteins or peptides from aminopeptidases
-
?
pyroglutamyl-Phe + H2O
pyroglutamate + Phe
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Phe-Pro-NH2 + H2O
pyroglutamate + Phe-Pro-NH2
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Ser + H2O
pyroglutamate + Ser
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Thr + H2O
pyroglutamate + Thr
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Trp + H2O
pyroglutamate + Trp
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Tyr + H2O
pyroglutamate + Tyr
show the reaction diagram
-
-
-
-
?
pyroglutamyl-Val + H2O
pyroglutamate + Val
show the reaction diagram
-
-
-
-
?
thyroliberin + H2O
pyroglutamate + His-Pro-NH2
show the reaction diagram
thyroliberin-releasing hormone + H2O
?
show the reaction diagram
-
-
-
-
?
thyrotrophin releasing hormone
?
show the reaction diagram
thyrotrophin-releasing hormone + H2O
?
show the reaction diagram
thyrotropin-releasing hormone + H2O
?
show the reaction diagram
additional information
?
-