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3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.19.3

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.3 pyroglutamyl-peptidase I

Storage Stability

Storage Stability on EC 3.4.19.3 - pyroglutamyl-peptidase I

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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C or 4°C, 24 h, more than 50% loss of activity of the enzyme solubilized by sodium deoxycholate and Triton X-100
-
-20°C, 50 mM phosphate buffer, pH 7, 10 mM 2-mercaptoethanol, 70% loss of activity after 1 month
-
-20°C, pH 7, in presence of 5 mM EDTA and 5 mM 2-mercaptoethanol, stable for 3 months
-
-20°C, rapid inactivation in presence of EDTA and 2-mercaptoethanol
-
-20°C, retains more than 90% of its activity for 1 month in the presence of a thiol-reducing agent
-80°C, 17% loss of activity after 4 weeks
-
4°C, -20°C or -70°C, 1 month, 90% loss of activity
-
4°C, 50 mM phosphate buffer, pH 7, 10 mM 2-mercaptoethanol, 13% loss of activity after 1 month
-
4°C, 72 h, 10% loss of activity of the enzyme solubilized in CHAPS
-
4°C, 72 h, 60% loss of activity of the enzyme solubilized in CHAPS
-
4°C, almost 60% of the initial activity is recovered after 1 month
-
4°C, pH 7, in presence of 5 mM EDTA and 5 mM 2-mercaptoethanol, less than 50% loss of activity
-
4°C, pH 7.8, stable for at least 1 week