3.4.19.3: pyroglutamyl-peptidase I
This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.
Word Map on EC 3.4.19.3
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3.4.19.3
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trh
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lymphocyte
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thymocytes
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thyrotropin-releasing
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cd8
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thyrotropin
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trh-degrading
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amyloliquefaciens
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deblocked
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analysis
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thyroliberin
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his-pro
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diketopiperazine
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l-pyroglutamic
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phytolacca
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hermes
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pancreatitis-associated
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adipokinetic
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litoralis
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post-proline
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protein-i
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cyclo
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3.4.21.26
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luliberin
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intrathymic
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medicine
- 3.4.19.3
- trh
- lymphocyte
- thymocytes
-
thyrotropin-releasing
- cd8
- thyrotropin
-
trh-degrading
- amyloliquefaciens
-
deblocked
- analysis
- thyroliberin
- his-pro
-
diketopiperazine
-
l-pyroglutamic
- phytolacca
- hermes
-
pancreatitis-associated
-
adipokinetic
- litoralis
-
post-proline
- protein-i
-
cyclo
-
3.4.21.26
- luliberin
-
intrathymic
- medicine
Reaction
release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =
Synonyms
5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase
ECTree
3.4.19.3 pyroglutamyl-peptidase IAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 3.4.19.3 - pyroglutamyl-peptidase I
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
orchidectomy increases activity of pyrrolidone carboxypeptidase type I, testosterone replacement returns it to control levels
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high levels of of soluble PGP I activity during the initial moments of development, in the fourth postnatal day activity starts to decrease until adulthood. Activity of the particulate form shows lowest values, during the first 20 days of life a significant decrease takes place, from this moment activity remains constant. No significant changes in activity of the particulate form
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high activity of soluble PGP I during the first days of development, between 20-30 postnatal days activity decreases significantly
pyroglutamyl-peptidase I is not involved in the aetilohy and pathology of coeliac disease
additional information
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activity dysregulation at different local and systemic levels may participate in the initiation, promotion and progression of breast cancer induced in rat by N-methyl nitrosourea through the increase of gonadotropin-releasing hormone
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pyroglutamate aminopeptidase II is predominantly localized in neuronal cells
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in the cortex, activity of soluble PGP I and particulate PGP I decreases 5fold and 4fold, respectively, from the embryo to the adult
orchidectomy increases activity of pyrrolidone carboxypeptidase type I, high dose of testosterone returns activity to control levels
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highest levels of soluble PGP I in all developmental stages, significant increase until 4 postnatal days, afterwards activity decreases slowly until 15 postnatal days, but subsequently continues to increase until 30 postnatal days. Activity of the particulate form increases until parturition day, until adulthood it remains constant with a small increase after 30 postnatal days
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activity of soluble PGP I does not change significantly until 20 postnatal days, significant increase between 20-30 postnatal days. Significant decrease in the activity of the particulate form from embryonic day 22 to the fourth postnatal day, until 90 postnatal days activity remains constant
no change in pyrrolidone carboxypeptidase type I after orchidectomy, activity increases after administration of testosterone
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highest level in particulate sperm fraction. Increased activity in necrozoospermia
