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3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.19.3

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.3 pyroglutamyl-peptidase I

KM Value

KM Value on EC 3.4.19.3 - pyroglutamyl-peptidase I

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.5 - 0.58
4(R)-N-(2-nitroxyethyl)-2-oxothiazolidine-4-carboxamide
0.079 - 0.089
gonadotropin-releasing hormone
0.33 - 0.42
L-2-oxoimidazolidine-4-carboxyl-L-Ala
1.53
L-2-oxooxazolidine-4-carboxyl-aminoethylnitrate
-
37°C, pH 7.4
0.55 - 0.71
L-2-oxooxazolidine-4-carboxyl-L-Ala
1.43
L-2-oxothiazolidine-4-carboxyl-D-2-aminopropylnitrate
-
37°C, pH 7.4
0.62
L-2-oxothiazolidine-4-carboxyl-ethanolamine
-
37°C, pH 7.4
0.57
L-2-oxothiazolidine-4-carboxyl-L-2-aminopropylnitrate
-
37°C, pH 7.4
0.3 - 0.43
L-2-oxothiazolidine-4-carboxyl-L-Ala
0.0335
L-pyroglutamyl p-nitroanilide
-
-
0.018 - 0.028
L-pyroglutamyl-7-amido-4-methylcoumarin
0.25
L-pyroglutamyl-Ala
-
-
0.14
L-pyroglutamyl-aminoethylnitrate
-
37°C, pH 7.4
0.29
L-pyroglutamyl-Arg
-
-
0.29
L-pyroglutamyl-Asp
-
-
0.17 - 1.46
L-pyroglutamyl-beta-naphthylamide
0.23
L-pyroglutamyl-Glu
-
-
0.2
L-pyroglutamyl-Gly
-
-
0.23
L-pyroglutamyl-His
-
-
0.045 - 0.89
L-pyroglutamyl-L-Ala
0.14
L-pyroglutamyl-L-Ile
-
-
-
0.24
L-pyroglutamyl-L-Thr
-
-
-
0.14
L-pyroglutamyl-Leu
-
-
0.2
L-pyroglutamyl-Lys
-
-
0.13
L-pyroglutamyl-Met
-
-
0.028 - 0.054
L-pyroglutamyl-p-nitroanilide
0.1
L-pyroglutamyl-Phe
-
-
0.15
L-pyroglutamyl-Ser
-
-
0.11
L-pyroglutamyl-Trp
-
-
0.2
L-pyroglutamyl-Tyr
-
-
0.09
L-pyroglutamyl-Val
-
-
0.49
luteinizing-hormone-releasing hormone
-
-
1.91
neurotensin
-
-
0.04 - 0.15
pyroglutamate-4-methylcoumarin 7-amide
0.059
pyroglutamic acid-7-amido-4-methylcoumarin
-
-
0.7
pyroglutamyl-2-naphthylamide
-
-
0.01536
pyroglutamyl-4-methylcoumarin 7-amide
-
-
0.05
pyroglutamyl-4-methylcoumaryl-7-amide
pH 7.8, 37°C
0.02076 - 1.79
Pyroglutamyl-beta-naphthylamide
0.00253 - 0.4198
pyroglutamyl-His-Pro-4-methylcoumarin 7-amide
0.0449
pyroglutamyl-His-Pro-NH2
-
-
0.73 - 20
pyroglutamyl-p-nitroanilide
0.04 - 0.727
Thyroliberin
0.59
thyroliberin-releasing hormone
-
-
-
0.05
thyrotrophic hormone releasing hormone
-
-
0.032 - 0.041
thyrotrophin-releasing hormone
0.041 - 0.056
thyrotropin-releasing hormone
additional information
additional information
-
-
-