3.4.19.3: pyroglutamyl-peptidase I

This is an abbreviated version!
For detailed information about pyroglutamyl-peptidase I, go to the full flat file.

Word Map on EC 3.4.19.3

3.4.19.3

trh

lymphocyte

thymocytes

thyrotropin-releasing

cd8

thyrotropin

trh-degrading

amyloliquefaciens

deblocked

analysis

thyroliberin

his-pro

diketopiperazine

l-pyroglutamic

phytolacca

hermes

pancreatitis-associated

adipokinetic

litoralis

post-proline

protein-i

cyclo

3.4.21.26

luliberin

intrathymic

medicine

Reaction

release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro =

Synonyms

5-oxoprolyl-peptidase, aminopeptidase, pyroglutamate, cysteine-free PCP, EC 3.4.11.8, L-pyrrolidonecarboxylate peptidase, PAP, PAP-I, PAP1, PCP, PCP-0SH, PGAP, PGP I, PGP-1, PGPEP1, PPI, PYR, PYRase, pyroglutamate aminopeptidase, pyroglutamidase, pyroglutamyl aminopeptidase, pyroglutamyl aminopeptidase I, pyroglutamyl peptidase I, pyroglutamyl peptidase type-1, pyroglutamyl type I aminopeptidase, pyroglutamyl-peptidase 1, pyroglutamylaminopeptidase, pyrrolidone carboxyeptidase, pyrrolidone carboxyl peptidase, pyrrolidone carboxypeptidase type I, pyrrolidone-carboxylate peptidase, pyrrolidonecarboxy peptidase, pyrrolidonecarboxylyl peptidase, pyrrolidonyl arylamidase, pyrrolidonyl peptidase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.19 Omega peptidases

3.4.19.3 pyroglutamyl-peptidase I

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Results	in table
19	Activating Compound
8134	AA Sequence
30	Application
1	CAS Registry Number
18	Cloned(Commentary)
8	Crystallization (Commentary)
125	Disease/ Diagnostics
9	General Stability
173	Inhibitors
7	Ki Value [mM]
89	KM Value [mM]
17	Localization
8	Metals/Ions
48	Molecular Weight [Da]
20	Natural Substrates/ Products (Substrates)
11	Organic Solvent Stability
127	Organism
1	Pathway
78	PDB ID
25	pH Optimum
7	pH Range
7	pH Stability
30	Protein Variants
23	Purification (Commentary)
1	Reaction
1	Reaction Type
126	Reference
2	Renatured (Commentary)
74	Source Tissue
18	Specific Activity [micromol/min/mg]
13	Storage Stability
198	Substrates and Products (Substrate)
24	Subunits
92	Synonyms
10	Temperature Optimum [°C]
4	Temperature Range [°C]
29	Temperature Stability [°C]
45	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.4.19.3 - pyroglutamyl-peptidase I

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1,10-phenanthroline

Gallus gallus

weak activation

95283

cyclosporin

Mus musculus

increases particulate and soluble PAP activity in the renal cortex. Particulate PAP activity returns to levels similar to controls after 15 days of cyclosporin withdrawal, soluble PAP does not regress. Soluble and particulate aminopeptidases in resident and elicited macrophages are unaffected by cyclosporin

DFP

weak activation

dithiothreitol

DTT

Thermococcus litoralis

enhances activity

653129

EDTA

2 entries

glucose

Rattus norvegicus

alters the hypothalamic activity of soluble PAP-I

682252

Insulin

Rattus norvegicus

alters the hypothalamic activity of soluble PAP-I

682252

methanol

Pyrococcus furiosus

a methanol based deblocking solution preserves enzymatic activity, provides conditions compatible with sequencing and enhances deblocking of electroblotted samples

PMSF

weak activation

thio-reducing agent

absolute requirement

tris(2-carboxyethyl)phosphine

Leishmania major

at least 0.5 mM required for full activity

681817