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3.4.19.2: peptidyl-glycinamidase

This is an abbreviated version!
For detailed information about peptidyl-glycinamidase, go to the full flat file.

Word Map on EC 3.4.19.2

Reaction

cleavage of C-terminal glycinamide from polypeptides =

Synonyms

carboxamidopeptidase, carboxyamidase, EC 3.4.15.2, glycinamidase, peptidyl, peptidyl amino acid amide hydrolase, peptidyl carboxy-amidase, peptidyl carboxyamidase, peptidyl-aminoacylamidase, peptidyl-glycinamidase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.19 Omega peptidases
                3.4.19.2 peptidyl-glycinamidase

Substrates Products

Substrates Products on EC 3.4.19.2 - peptidyl-glycinamidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-L-Trp ethyl ester + H2O
?
show the reaction diagram
toad
-
-
-
-
?
alpha-aminosuberic acid + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-aminosuberic acid oxytocin + H2O
glycinamide + ?
show the reaction diagram
-
-
-
?
alpha-deamino-cystathionine + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-deamino-cystathionine-6,1-oxytocin + H2O
glycinamide + ?
show the reaction diagram
-
-
-
?
antidiuretic hormone + H2O
glycinamide + ?
show the reaction diagram
-
release of glycinamide from the C-terminus of the hormone
-
?
benzoyl-L-Arg ethyl ester + H2O
?
show the reaction diagram
toad
-
-
-
-
?
beta-deamino-cystathionine-1,6-oxytocin + H2O
glycinamide + ?
show the reaction diagram
-
-
-
?
oxytocin + H2O
?
show the reaction diagram
-
the enzyme is not a strict peptidyl-glycinamidase, but can release other amino acid amides from a variety of amidated peptide
-
-
?
oxytocin + H2O
glycinamide + ?
show the reaction diagram
Vasopressin + H2O
?
show the reaction diagram
-
-
-
-
?
[Arg8]-vasopressin + H2O
?
show the reaction diagram
toad
-
hydrolysis of the Arg8-Gly9-NH2 bond
-
-
?
additional information
?
-
toad
-
enzyme inactivates neurophyseal hormones
-
-
?