3.4.19.12: ubiquitinyl hydrolase 1
This is an abbreviated version!
For detailed information about ubiquitinyl hydrolase 1, go to the full flat file.
Word Map on EC 3.4.19.12
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3.4.19.12
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nerve
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proteasome
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neurodegenerative
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fiber
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innervation
-
deubiquitinase
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polyglutamine
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ataxia
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parkinsonism
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spinocerebellar
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ubiquitin-proteasome
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polyubiquitinated
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glial
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sars-cov-2
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coronavirus
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covid-19
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calcitonin
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neurofilament
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fibrillary
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neuropeptide
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neuron-specific
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traumatic
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gene-related
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cyld
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parkin
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polyq
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synaptophysin
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ubiquitin-like
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polyproteins
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usp7
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ubiquitin-dependent
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alpha-synuclein
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deubiquitylating
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npy
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myenteric
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3clpro
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monoubiquitination
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nedd8
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cd45ro
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isg15
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intraepidermal
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k48-linked
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spermatogonial
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mono-ubiquitinated
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ubiquitin-binding
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3c-like
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mers-cov
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medicine
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isopeptide
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degradation
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synthesis
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diagnostics
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anti-sars-cov-2
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molecular biology
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analysis
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concussion
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pharmacology
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drug development
- 3.4.19.12
- nerve
- proteasome
- neurodegenerative
- fiber
-
innervation
-
deubiquitinase
-
polyglutamine
- ataxia
- parkinsonism
- spinocerebellar
-
ubiquitin-proteasome
-
polyubiquitinated
- glial
- sars-cov-2
- coronavirus
- covid-19
- calcitonin
- neurofilament
-
fibrillary
-
neuropeptide
-
neuron-specific
-
traumatic
-
gene-related
- cyld
- parkin
-
polyq
-
synaptophysin
-
ubiquitin-like
- polyproteins
- usp7
-
ubiquitin-dependent
- alpha-synuclein
-
deubiquitylating
- npy
-
myenteric
- 3clpro
-
monoubiquitination
- nedd8
-
cd45ro
- isg15
-
intraepidermal
-
k48-linked
- spermatogonial
-
mono-ubiquitinated
-
ubiquitin-binding
-
3c-like
- mers-cov
- medicine
-
isopeptide
- degradation
- synthesis
- diagnostics
-
anti-sars-cov-2
- molecular biology
- analysis
- concussion
- pharmacology
- drug development
Reaction
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) =
Synonyms
A20, AD-019, AMSH, associated molecule with the SH3-domain of STAM, AT-3, ataxin-3, BAP1, BPLF1, BRCA1-associated protein-1, C-terminal hydrolases UCHL3, C-terminal ubiquitin hydrolase, Cezanne, CGI-70, CYLD, de-ubiquitinating enzyme, deubiquinating isopeptidase T, deubiquitinating enzyme, Doa4, Doa4 ubiquitin hydrolase, Doa4p ubiquitin isopeptidase, DUB, dUCH, EC 3.1.2.15, esterase, ubiquitin thiol-, hydrolase, ubiquitin carboxyl-terminal, hydrolase, ubiquitin carboxyl-terminal (Aplysia californica gene Ap-uch), Iso-T, isopeptidase, isopeptidase T, More, Neuron cytoplasmic protein 9.5, neuronal-specific protein gene product 9.5, OsUCH1, OsUCH2, OsUCH3, OsUCH4, OsUCH5, OTU-1, OTUB1, OTUB2, Otubain-1, Otubain-2, ovarian tumour 1, PA-700 associated isopeptidase, papain-like protease, PGP 9.5, PGP 9.5/UCHL1, PGP9.5, PGP9.5.1, PLP2, PLpro, Ub isopeptidase, ubiquitin C terminal hydrolase 1, ubiquitin C-terminal hydrolase, ubiquitin C-terminal hydrolase (Aplysia californica gene Ap-uch), ubiquitin C-terminal hydrolase 1, ubiquitin C-terminal hydrolase 37, ubiquitin C-terminal hydrolase 8, ubiquitin C-terminal hydrolase isoform L3, ubiquitin C-terminal hydrolase L-1, ubiquitin C-terminal hydrolase L1, ubiquitin C-terminal hydrolase L3, Ubiquitin C-terminal hydrolase UCH37, ubiquitin C-terminal hydrolase-1, ubiquitin C-terminal hydrolase-L1, ubiquitin C-terminal hydrolase-L3, ubiquitin C-terminal hydrolase-L5, ubiquitin C-terminal hydrorase-L1, ubiquitin carboxy terminal hydrolase-L1, ubiquitin carboxy terminal hydrolase-L3, ubiquitin carboxy-terminal hydrolase, ubiquitin carboxy-terminal hydrolase 1, ubiquitin carboxy-terminal hydrolase L1, ubiquitin carboxy-terminal hydrolase-L1, ubiquitin carboxy-terminal hydrolase-L3, ubiquitin carboxyhydrolase L3, ubiquitin carboxyl terminal esterase L1, ubiquitin carboxyl terminal hydrolase 1, ubiquitin carboxyl terminal hydrolase L1, ubiquitin carboxyl terminal hydrolase-L1, ubiquitin carboxyl-terminal hydrolase, ubiquitin carboxyl-terminal hydrolase 1, ubiquitin carboxyl-terminal hydrolase 44, ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin carboxyl-terminal hydrolase L-1, ubiquitin carboxyl-terminal hydrolase L1, ubiquitin carboxyl-terminal hydrolase l3, ubiquitin carboxyl-terminal hydrolase L5, ubiquitin carboxyl-terminal hydrolase-L1, ubiquitin carboxyl-terminal hydrolase-L5, ubiquitin carboxyterminal hydrolase L1, ubiquitin carboxyterminal hydrolase L3, ubiquitin carboxyterminal hydrolase-L1, ubiquitin hydrolase, ubiquitin hydrolase Uch-L1, ubiquitin hydrolase UCH-L3, ubiquitin isopeptidase, Ubiquitin thiolesterase, Ubiquitin thiolesterase L1, Ubiquitin thiolesterase L3, Ubiquitin thiolesterase L4, Ubiquitin thiolesterase L5, ubiquitin-C-terminal hydrolase L1, ubiquitin-carboxyl-terminal hydrolase PGP-9.5, ubiquitin-specific protease 44, UBPY, UCH, UCH L-1, UCH L1, UCH-1, UCH-8, UCH-L1, UCH-L2, UCH-L3, UCH-L4, UCH-L5, UCH37, UCH54, UCHL-1, UCHL-3, UCHL1, UCHL1/PGP 9.5, UCHL2, Uchl3, UCHL5, UCHL5N240, USP19, USP22, USP44, yeast ubiquitin hydrolase, YUH, YUH1
ECTree
3.4.19.12 ubiquitinyl hydrolase 1Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.19.12 - ubiquitinyl hydrolase 1
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
type I TGF-beta receptor + H2O
?
UCH37 deubiquitinates and stabilizes type I TGF-beta receptor. Overexpression of UCH37 upregulates TGF-beta-dependent transcription
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-
?
ubiquitinyl-Smad2 + H2O
ubiquitin + Smad2
the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability
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-
?
ubiquitinyl-Smad3 + H2O
ubiquitin + Smad3
the enzyme de-ubiquitinates both Smad2 and Smad3 and up-regulates their stability
-
-
?
polyubiquitin + H2O
ubiquitin
-
substrate of UCHL3, no activity with UCHL1/PGP 9.5
-
-
?
polyubiquitin + H2O
ubiquitin
-
disassembly of polyubiquitin, terminal step of the proteasome pathway, scheme
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?
polyubiquitin + H2O
ubiquitin
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inhibition by prostaglandins of the J series leads to accumulation of polyubiquitins of MW around 250 kDa
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?
polyubiquitin + H2O
ubiquitin
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substrate of UCHL3, no activity with UCHL1/PGP 9.5
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-
?
polyubiquitin + H2O
ubiquitin
UCHL5 deubiquitylates the polyubiquitin chain into ubiquitin
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-
?
polyubiquitin + H2O
ubiquitin
UCHL5 deubiquitylates the polyubiquitin chain into ubiquitin
-
-
?
ubiquitin-CEP52 + H2O
ubiquitin + CEP52
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substrate of UCHL1/PGP 9.5, no activity with UCHL3
-
-
?
ubiquitin-CEP52 + H2O
ubiquitin + CEP52
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substrate of UCHL1/PGP 9.5, no activity with UCHL3
-
-
?
ubiquitin-CEP80 + H2O
ubiquitin + CEP80
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substrate of UCHL3 and UCHL1/PGP 9.5
-
-
?
ubiquitin-CEP80 + H2O
ubiquitin + CEP80
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substrate of UCHL3 and UCHL1/PGP 9.5
-
-
?
ubiquitin-peptide + H2O
?
-
UCH enzymes may function to regenerate active ubiquitin from adducts with small nuceleophiles
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-
?
ubiquitin-protein + H2O
ubiquitin + protein
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enzyme is crucial for polarization of the actin cytoskeleton, to segregate germline determinants, to assemble an intact cleavage furrow, for cytokinesis and to maintain osmotic balance and execute actin-dependent processes in the early embryo
-
?
ubiquitin-protein + H2O
ubiquitin + protein
important role in regulation of cell growth
-
?
ubiquitin-protein + H2O
ubiquitin + protein
-
involved in endocytotic pathway of plasma membrane proteins
-
?
ubiquitin-protein + H2O
ubiquitin + protein
-
Doap4 enzyme form plays a general role in deubiquination of membrane-bound proteins
-
?
additional information
?
-
-
uch-L1 may have an important role in the development of neuronal cells in early embryos as well as in the degeneration and disease of neuronal cells in late adult brain. The gene for ubiquitin C-terminal hydrolase L1 is associated with inherited forms of Parkinson's disease
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-
?
additional information
?
-
uch-L1 may have an important role in the development of neuronal cells in early embryos as well as in the degeneration and disease of neuronal cells in late adult brain. The gene for ubiquitin C-terminal hydrolase L1 is associated with inherited forms of Parkinson's disease
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-
?
additional information
?
-
increased activity of neuronal isozyme L1 reduces the risk for Parkinson's disease
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-
?
additional information
?
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increased activity of neuronal isozyme L1 reduces the risk for Parkinson's disease
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-
?
additional information
?
-
-
AMSH is a deubiquinating enzyme with functions at the endosome, it opposes the ubiquitin-dependent sorting of receptors to lysosomes, the enzyme influences the degradation of the EGF receptor by association to endosomes, model of the enzyme's physiological function
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-
?
additional information
?
-
gene uch-L1 is involved in development of Parkinson's disease
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-
?
additional information
?
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gene uch-L1 is involved in development of Parkinson's disease
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-
?
additional information
?
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the enzyme is involved in generation of free monomeric ubiquitin, enzyme deficiency leads is involved in accumulation of ubiquitin and alpha-synuclein leading to aggregation in proteins conforming Lewy bodies and Lewy neurites leading to Parkinson's disease and dementia with Lewy bodies, the enzyme is down-regulated in Alzheimer's disease and in Parkinson's disease, comparison of enzyme expression to general protein synthesis and proteasome activity in brain
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-
?
additional information
?
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the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation
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-
?
additional information
?
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the full length UCH-L1 is a de-ubiquinating enzyme in brain, and a major target of oxidative damage in Alzheimer's diesease and Parkinson's disease brains, modified by cysteine and methionine oxidation and carbonyl formation
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-
?
additional information
?
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ubiquitin carboxy-terminal hydrolase L1 activates the P2X receptor leading to potentiation of ATP-induced currents in neurons
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-
?
additional information
?
-
UCH-L1 is involved in Parkinson's disease
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-
?
additional information
?
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UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
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-
?
additional information
?
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oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases
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-
?
additional information
?
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oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinsons and Alzheimers diseases
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-
?
additional information
?
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UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress
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-
?
additional information
?
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UCHL1 is an essential gene in cell survival under normal growth conditions and against oxidative stress
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-
?
additional information
?
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UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions
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?
additional information
?
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UCHL1 is an essential gene to maintain cell homeostasis under normal growth and oxidative stress conditions
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?
additional information
?
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UCHL1 is associated with Parkinsons disease
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-
?
additional information
?
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Bap1 helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G1-S transition
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-
?
additional information
?
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epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas and other digestive tumors. UCHL1 appears to be a functional tumor suppressor involved in the tumorigenesis of hepatocellular carcinomas and other digestive cancers. Ectopic expression of UCHL1 induces apoptosis through intrinsic caspase-dependent pathway. UCHL1 directly interacts with p53 and inhibits p53 protein degradation
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-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L1 in vivo
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-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L1 in vivo
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-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L3 in vivo
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-
?
additional information
?
-
mono-ubiquitin and ubiquitin dimers may regulate the enzymatic function of UCH-L3 in vivo
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-
?
additional information
?
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role for UCH-L1 and ubiquitin modification in podocyte differentiation and injury
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-
?
additional information
?
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role for UCH-L1 and ubiquitin modification in podocyte differentiation and injury
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-
?
additional information
?
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silencing of UCH-L1 in MCF7/Adr cells does not suppress cell growth. Overexpression of UCH-L1 in MCF7 cells induces apoptosis. Apoptosis triggered by UCH-L1 is, at least in part, probably through phosphoinositide 3-kinase/Akt signal pathway
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-
?
additional information
?
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silencing of UCH-L1 in MCF7/Adr cells does not suppress cell growth. Overexpression of UCH-L1 in MCF7 cells induces apoptosis. Apoptosis triggered by UCH-L1 is, at least in part, probably through phosphoinositide 3-kinase/Akt signal pathway
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-
?
additional information
?
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UCH-L1 is a key molecule to regulate tumor-cell invasion by upstream activation of Akt. Expression of UCH-L1 in tumor cells enhances their invasive potential in vitro and in vivo. UCH-L1 changes cell morphology by regulating cell adhesion through Akt-mediated pathway
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-
?
additional information
?
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-
UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells
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-
?
additional information
?
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UCH-L1 is a player in the signaling pathways that promote the proliferation and invasive capacity of malignant B-cells
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-
?
additional information
?
-
Uch37 activities can be modulated both positively and negatively via dynamic interactions with partner proteins, whereby the proteasome and the hINO80 chromatin-remodeling complex may cooperate to regulate transcription or DNA repair
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-
?
additional information
?
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-
Uch37 activities can be modulated both positively and negatively via dynamic interactions with partner proteins, whereby the proteasome and the hINO80 chromatin-remodeling complex may cooperate to regulate transcription or DNA repair
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-
?
additional information
?
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interaction of the ubiquitin carboxyl terminal esterase L1 with alpha2-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation. Uch-L1 binds specifically to the third intracellular loop of alpha2A adrenergic receptor, but also to the respective loops of adrenergic receptors alpha2B, alpha2C, and beta2, overview
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-
?
additional information
?
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-
polyubiquitin processing, overview. UCHL1/PGP 9.5 also shows ligase activity when in a dimeric form, overview
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-
?
additional information
?
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-
the proteasomal pathway is partially inhibited by UCH-L1M
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-
?
additional information
?
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UCH L1 forms endogenous complexes with beta-catenin and stabilizes it. The expression and deubiquitinating activity of UCHL1 are required for its own basic promoter activity, therefore UCH L1 up-regulates its expression by activation of the oncogenic beta-catenin/TCF signaling in transformed cells
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-
?
additional information
?
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UCH-L1 can hydrolyze isopeptide bonds between the C-terminal glycine of Ub and the alpha- or gamma-amino group of lysine on the target proteins. UCH-L3 recognizes and hydrolyzes isopeptide bonds at the C-terminal glycine of either ubiquitin or Nedd8, a ubiquitin-like protein. It shows no ligase activity. UCH-L3 can interact with Lys48-linked ubiquitin dimers to protect it from degradation and meanwhile to inhibit its hydrolase activity, D33 and C95 are essential for the interaction with di-ubiquitin. Neither UCH37 alone nor the UCH37-Adrm1 or UCH37-Adrm1-hRpn2 complexes can hydrolyse Lys48-linked di-ubiquitin efficiently, rather, their incorporation into the 19S complex is required to enable UCH37 to process large ubiquitin protein conjugates such as di-ubiquitin
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-
?
additional information
?
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-
UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts
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-
?
additional information
?
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UCH-L1 is a deubiquitinating enzyme that catalyses the hydrolysis of polyubiquitin precursors and small ubiquitin adducts
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-
?
additional information
?
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-
UCH-L1 is a deubiquitinating enzyme. UCH-L1 increases the synthesis of cystic fibrosis transmembrane conductance regulator, CFTR, but has little effect on the rate of post-translational degradation
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-
?
additional information
?
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shRNA decreases mRNA levels and reduces viral genome production. EBV deubiquitinating enzyme BPLF1 interacts with, deubiquitinates, and influences the activity of the Epstein-Barr virus ribonucleotide reductase
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-
?
additional information
?
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shRNA decreases mRNA levels and reduces viral genome production. EBV deubiquitinating enzyme BPLF1 interacts with, deubiquitinates, and influences the activity of the Epstein-Barr virus ribonucleotide reductase
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?
additional information
?
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the enzyme is necessary for placental and fetal development
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?
additional information
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the enzyme is necessary for placental and fetal development
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?
additional information
?
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Uch-L1, via the ubiquitin-proteasome system, may play an important role not only in gametogenesis, but also in the gonadal transformation process in the rice field eel
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?
additional information
?
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isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
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-
?
additional information
?
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isozyme L1 associates and colocalizes with monoubiquitin and elongates ubiquitin half-life, null mutants show a reduced monoubiquitin level in neurons, while overexpression causes an increase in monoubiquitin level, mechanism
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-
?
additional information
?
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-
the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
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-
?
additional information
?
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the closely related isozymes UCH-L1 and UCH-L3 function as reciprocal modulators of germ cell apoptosis in cryptorchid testis
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?
additional information
?
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the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
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?
additional information
?
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the enzyme is essential for the early apoptotic wave of germinal cells and for sperm quality control during spermatogenesis
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?
additional information
?
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the enzyme is involved in spermatogenesis
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-
?
additional information
?
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the enzyme is involved in spermatogenesis
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?
additional information
?
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the enzyme plays a role in neural cell apoptosis induced by ischemic retinal injury, e.g. in mice with gracile axonal dystrophy, overview
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-
?
additional information
?
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UCH-L1 functions in sperm quality control during epididymal maturation
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?
additional information
?
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UCH-L1 functions in sperm quality control during epididymal maturation
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?
additional information
?
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UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
-
UCH-L1 regulates the morphology of neural progenitor cells and modulates their differentiation, it mediates and enhances neurogenesis in the embryonic brain
-
-
?
additional information
?
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Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
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?
additional information
?
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Uchl3 is involved in working memory, and plays a role in learning, memory, and synaptic plasticity, uchl3-deficient mice are impaired in acquisition of hippocampus-dependent tasks requiring learning and remembering, but show wild-type long-term memory for context and cued fear conditioning, uchl3-/- mice exhibit wild-type synaptic transmission and plasticity in hippocampal area CA1, overview
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?
additional information
?
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affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
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?
additional information
?
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affects ubiquitin degradation and alters its metabolism. UCH-L1-mediated increases in ubiquitin levels are a function of UCH L1 affinity for ubiquitin rather than hydrolase activity. The enzyme insures ubiquitin stability within neurons
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?
additional information
?
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gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
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?
additional information
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gracile axonal dystrophy is a syndrome that emanates from dysfunctional ubiquitin carboxyl-terminal hydrolase L-1
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?
additional information
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mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
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?
additional information
?
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mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage of meiosis. Overexpression of UCH-L1 affects spermatogenesis during meiosis and, in particular, induces apoptosis in primary spermatocytes. UCH-L-1 plays a specific role in the process of mitotic proliferation and differentiation of spermatogonial stem cells during spermatogenesis
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?
additional information
?
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the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
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?
additional information
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the enzyme may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm
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?
additional information
?
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ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
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?
additional information
?
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ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory
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?
additional information
?
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ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
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?
additional information
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ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory
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?
additional information
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UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
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?
additional information
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UCH-L1 may play an important role in neurodegeneration of amyloid lateral sclerosis
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?
additional information
?
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UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
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?
additional information
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UCHL1 is required for normal spermatogenesis and sperm quality control. UCHL1-dependent apoptosis is important in spermatogonial cell and sperm maturation
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?
additional information
?
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CYLD negatively regulates RANK signaling by inhibiting TRAF6 ubiquitination and activation of downstream signaling events. CYLD interacts physically with the signaling adaptor p62 and thereby is recruited to TRAF6. CYLD is a crucial negative regulator of osteoclastogenesis and may be involved in the p62/TRAF6 signaling axis
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?
additional information
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is overexpressed in alpha-tocopherol deficient mice
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additional information
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mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
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?
additional information
?
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mono-ubiquitin and ubiquitin dimers may regulate the enzymatic functions of UCH-L3, in vivo
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?
additional information
?
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UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
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?
additional information
?
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UCH-L1 expression levels show a time-dependent upregulation in mice ischemia-reperfusion injury condition. Germ cell apoptosis triggers downregulation of UCH-L1 at both mRNA and protein levels, thus, ubiquitination level is impaired. Eevidences of UCH-L1/ubiquitination signaling to the testis ischemia-reperfusion injury in vivo
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additional information
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UCH-L1 is a deubiquitinating enzyme, it binds to and stabilize mono-ubiquitin in neurons
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additional information
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UCH-L1 is a deubiquitinating enzyme, it binds to and stabilizes mono-ubiquitin in neurons
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additional information
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de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
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additional information
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de novo synthesis of isozyme UCH-L1 in rostral ventrolateral medulla is crucial to survival during mevinphos intoxication, the enzyme is involved in synthesis of ubiquitin which is required for protein targeting in degradation in the ubiquitin-proteasome pathway in neurons, UCH-L1 plays a neuroprotective role
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additional information
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overexpression of UCH L1 potentiates ATP-induced currents due to the activation of P2X receptors that are widely distributed in the brain and involved in various biological activities including neurosecretion. UCH-L1 may play an important role in synaptic activity
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additional information
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UCHL1 can act as a ubiquitin hydrolase, and generate free ubiquitin species from precursor ubiquitin polypeptides. Synaptic activation of UCH-L1 is correlated with an increase in the levels of free monomeric ubiquitin
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