3.4.18.1: cathepsin X
This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.
Word Map on EC 3.4.18.1
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3.4.18.1
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cathepsins
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papain-like
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procathepsins
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saitoi
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diagnostics
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galactosialidosis
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medicine
- 3.4.18.1
- cathepsins
-
papain-like
-
procathepsins
- saitoi
- diagnostics
-
galactosialidosis
- medicine
Reaction
Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =
Synonyms
acid carboxypeptidase, cathepsin B2, cathepsin IV, cathepsin P, cathepsin X, cathepsin Z, CATX, CTPZ, CTSX, CTSZ, cysteine-type carboxypeptidase, lysosomal carboxypeptidase B, mopre, PoCtX
ECTree
3.4.18.1 cathepsin XAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.18.1 - cathepsin X
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
cathepsin X can be secreted by nonhematopoietic bone marrow cells in an activated form
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healthy, aging, and pathological, expression patterns of cathepsin X, overview
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upregulation in gastric cancer compared to non-neoplastic mucosa. Patients with Helicobacter pylori gastritis show significantly higher cathepsin X mRNA (2.5fold) and protein (1.6fold) expression than Helicobacter pylori-negative partients
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protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer
cumulus cells surrounding germinal vesicle oocytes harvested from adult versus prepubertal animals, developmental expression profile, overview, the enzyme expression is severalfold higher in prepubertal cells
the enzyme accumulates in vesicles at lamellipodia
additional information
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the enzyme is upregulated in glia cells of degenerating brain regions in a transgenic mouse model of amyotrophic lateral sclerosis
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a human myeloblast cell line, derived from bone marrow aspirate obtained from male with erythroleukemia that evolved into acute myelogenous leukemia. KG-1 cells differentiate to macrophage like cells, express significant amount of cathepsin X
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protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer
additional information
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enzyme is found in whole body extracts of metacercariae , newly excysted juveniles and 2 week-old juveniles, but not in 3, 4 week-old juveniles and adult flukes, with presence of cathepsin B2 only in the caecal epithelium of metacercariae, newly excysted juveniles and 2 week-old juveniles
additional information
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the cell lines MCF-10A neoT and MDA-MB 231 are negative for cathepsin
additional information
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tissue distribution, immunohistochemic analysis, overview
additional information
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strongly upregulated in infected gastric mucosa and intestinal-type gastric cancer
additional information
cathepsin X is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage
additional information
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cathepsin X is a lysosomal cysteine protease, found predominantly in cells of monocyte/macrophage lineage
additional information
cathepsin X shows marked co-localization with Mac-1 integrin receptor on the plasma membrane of differentiated THP-1 cells primed with Helicobacter pylori antigen of group A of therapy-resistant strains. Priming with Helicobacter pylori antigen of groupB of therapy-susceptible strains results in less extensive co-localization with Mac-1
additional information
no enzyme secretion from hematopoietic stem and progenitor cells, e.g. CD34+ HSPC, G292 cells
additional information
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no enzyme secretion from hematopoietic stem and progenitor cells, e.g. CD34+ HSPC, G292 cells
additional information
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tissue distribution, immunohistochemic analysis, overview
