3.4.18.1: cathepsin X

This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.

Word Map on EC 3.4.18.1

Reaction

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =

Synonyms

cathepsin B2, cathepsin IV, acid carboxypeptidase, lysosomal carboxypeptidase B, cathepsin Z, cysteine-type carboxypeptidase, cathepsin X, CATX, CTPZ, CTSZ, PoCtX, CTSX, mopre, cathepsin P

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.18 Cysteine-type carboxypeptidases
                3.4.18.1 cathepsin X

Source Tissue

Source Tissue on EC 3.4.18.1 - cathepsin X

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
cathepsin X can be secreted by nonhematopoietic bone marrow cells in an activated form
Manually annotated by BRENDA team
microglial cell
Manually annotated by BRENDA team
an osteoblastic cell line
Manually annotated by BRENDA team
-
healthy, aging, and pathological, expression patterns of cathepsin X, overview
Manually annotated by BRENDA team
microglial cell
Manually annotated by BRENDA team
-
upregulation in gastric cancer compared to non-neoplastic mucosa. Patients with Helicobacter pylori gastritis show significantly higher cathepsin X mRNA (2.5fold) and protein (1.6fold) expression than Helicobacter pylori-negative partients
Manually annotated by BRENDA team
a bone marrow stromal cell line
Manually annotated by BRENDA team
a bone marrow stromal cell line
Manually annotated by BRENDA team
-
protein level of cathespin X does not differ significantly between matched pairs of lung tumor and adjacent lung tissue ontained from patients with lung cancer
Manually annotated by BRENDA team
-
human gastric epithelial cell
Manually annotated by BRENDA team
-
very low enzyme content
Manually annotated by BRENDA team
enzyme mRNA accumulation during maturation
Manually annotated by BRENDA team
cumulus cells surrounding germinal vesicle oocytes harvested from adult versus prepubertal animals, developmental expression profile, overview, the enzyme expression is severalfold higher in prepubertal cells
Manually annotated by BRENDA team
the enzyme accumulates in vesicles at lamellipodia
Manually annotated by BRENDA team
additional information