3.4.18.1: cathepsin X

This is an abbreviated version!
For detailed information about cathepsin X, go to the full flat file.

Word Map on EC 3.4.18.1

Reaction

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity =

Synonyms

cathepsin B2, cathepsin IV, acid carboxypeptidase, lysosomal carboxypeptidase B, cathepsin Z, cysteine-type carboxypeptidase, cathepsin X, CATX, CTPZ, CTSZ, PoCtX, CTSX, mopre, cathepsin P

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.18 Cysteine-type carboxypeptidases
                3.4.18.1 cathepsin X

Expression

Expression on EC 3.4.18.1 - cathepsin X

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Helicobacter pylori antigens from subjects with gastritis, who are successful in eradicating the infection after antibiotic therapy, decrease the membrane expression of cathepsin X in THP-1 cells
Helicobacter pylori antigens from subjects with gastritis, who are unsuccessful in eradicating the infection after antibiotic therapy, increase the membrane expression of cathepsin X in THP-1 cells
the enzyme is upregulated in several types of cancer