3.4.17.21: Glutamate carboxypeptidase II

This is an abbreviated version!
For detailed information about Glutamate carboxypeptidase II, go to the full flat file.

Reaction

release of an unsubstituted, C-terminal glutamyl residue, typically from Ac-Asp-Glu or folylpoly-gamma-glutamates =

Synonyms

100 kDa ileum brush border membrane protein, Acetylaspartylglutamate dipeptidase, altered meristem program1, AMP1, Dipeptidase, acetylaspartylglutamate, EC 3.4.19.8, FGCP, folate hydrolase, folate hydrolase 1, FOLH1, Folylpoly-gamma-glutamate carboxypeptidase, folylpoly-gamma-glutamate carboxypeptidase II, GCP II, GCPII, GCPIII, glutamate carboxypeptidase, glutamate carboxypeptidase II, glutamate carboxypeptidase III, GPCPII, I100, Ileal dipeptidylpeptidase, Membrane glutamate carboxypeptidase, mGCP, More, N-acetyl-alpha-linked acidic dipeptidase, N-acetyl-alpha-linked acidic dipeptidase I, N-acetylaspartylglutamate peptidase, N-acetylated alpha-linked acid dipeptidase, N-Acetylated alpha-linked acidic dipeptidase, N-Acetylated-alpha-linked acidic dipeptidase, N-acetylated-alpha-linked acidic dipeptidase 2, N-acetylated-alpha-linked acidic dipeptidase II, N-Acetylated-alpha-linked-acidic dipeptidase, N-acetylated-alpha-linked-acidic-dipeptidase, N-Acetylated-alpha-linked-amino dipeptidase, NAADLADase, NAADLADse, NAAG degradation enzyme, NAAG peptidase, NAAG peptidase II, NAAG-hydrolyzing activity, NAALA dipeptidase, NAALADase, Naaladase I, NAALADase II, NLD I, PMSA, prostate specific membrane antigen, Prostate-specific membrane antigen, Prostate-specific membrane antigen homolog, prostate-specificmembrane antigen, Prostrate-specific membrane antigen, PSM, PSM antigen, PSMA, Pteroylpoly-gamma-glutamate carboxypeptidase, Rat NAAG peptidase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.17 Metallocarboxypeptidases

                3.4.17.21 Glutamate carboxypeptidase II

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Results	in table
1	Activating Compound
189	AA Sequence
40	Application
1	CAS Registry Number
25	Cloned(Commentary)
12	Crystallization (Commentary)
7461	Disease/ Diagnostics
5	Expression
9	General Information
3	General Stability
121	IC50 Value
374	Inhibitors
4	kcat/KM [mM/s]
108	Ki Value [mM]
15	KM Value [mM]
83	Localization
41	Metals/Ions
8	Molecular Weight [Da]
62	Natural Substrates/ Products (Substrates)
128	Organism
2	Pathway
90	PDB ID
15	pH Optimum
2	pH Range
17	Posttranslational Modification
37	Protein Variants
14	Purification (Commentary)
4	Reaction
7	Reaction Type
126	Reference
230	Source Tissue
10	Specific Activity [micromol/min/mg]
144	Substrates and Products (Substrate)
10	Subunits
261	Synonyms
14	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Turnover Number [1/s]

Synonyms

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Synonyms on EC 3.4.17.21 - Glutamate carboxypeptidase II

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100 kDa ileum brush border membrane protein

-

-

-

-

Acetylaspartylglutamate dipeptidase

-

-

-

-

altered meristem program1

Arabidopsis thaliana

Q9M1S8

-

732580

AMP1

Arabidopsis thaliana

Q9M1S8

-

732580

Dipeptidase, acetylaspartylglutamate

-

-

-

-

EC 3.4.19.8

-

-

formerly

-

FGCP

2 entries

folate hydrolase

2 entries

folate hydrolase 1

Mus musculus

-

-

701258

FOLH1

2 entries

Folylpoly-gamma-glutamate carboxypeptidase

-

-

-

-

folylpoly-gamma-glutamate carboxypeptidase II

Homo sapiens

-

-

697394

GCP II

4 entries

GCPII

9 entries

GCPIII

3 entries

glutamate carboxypeptidase

Homo sapiens

-

-

707988

glutamate carboxypeptidase II

7 entries

glutamate carboxypeptidase III

2 entries

GPCPII

2 entries

I100

-

-

-

-

Ileal dipeptidylpeptidase

-

-

-

-

Membrane glutamate carboxypeptidase

-

-

-

-

mGCP

-

-

-

-

N-acetyl-alpha-linked acidic dipeptidase

Rattus norvegicus

-

-

668486

N-acetyl-alpha-linked acidic dipeptidase I

Homo sapiens

Q04609

-

670685

N-acetylaspartylglutamate peptidase

2 entries

N-acetylated alpha-linked acid dipeptidase

Rattus norvegicus

-

-

656609

N-Acetylated alpha-linked acidic dipeptidase

6 entries

N-Acetylated-alpha-linked acidic dipeptidase

2 entries

N-acetylated-alpha-linked acidic dipeptidase 2

Mus musculus

Q9CZR2

-

669923

N-acetylated-alpha-linked acidic dipeptidase II

Mus musculus

Q9CZR2

-

669923

N-Acetylated-alpha-linked-acidic dipeptidase

2 entries

N-acetylated-alpha-linked-acidic-dipeptidase

Mus musculus

-

-

701258

N-Acetylated-alpha-linked-amino dipeptidase

-

-

-

-

NAADLADase

Rattus norvegicus

-

-

655503

NAADLADse

Homo sapiens

-

-

668866

NAAG degradation enzyme

Rattus norvegicus

-

-

708400

NAAG peptidase

3 entries

NAAG peptidase II

Mus musculus

Q9CZR2

-

669923

NAAG-hydrolyzing activity

Homo sapiens

-

-

670817

NAALA dipeptidase

-

-

-

-

NAALADase

7 entries

Naaladase I

Homo sapiens

Q04609

-

670685

NAALADase II

Mus musculus

Q9CZR2

-

669923

NLD I

Homo sapiens

Q04609

-

670685

PMSA

2 entries

prostate specific membrane antigen

2 entries

Prostate-specific membrane antigen

8 entries

Prostate-specific membrane antigen homolog

-

-

-

-

prostate-specificmembrane antigen

Homo sapiens

-

-

708325

Prostrate-specific membrane antigen

-

-

-

-

PSM

-

-

-

-

PSM antigen

-

-

-

-

PSMA

8 entries

Pteroylpoly-gamma-glutamate carboxypeptidase

-

-

-

-

Rat NAAG peptidase

-

-

-

-

additional information

Homo sapiens

-

glutamate carboxypeptidase III and glutamate carboxypeptidase II belong to the transferrin receptor/glutamate carboxypeptidase II superfamily

708479

FGCP

-

-

-

-

FGCP

Homo sapiens

-

-

697394

folate hydrolase

Homo sapiens

Q04609

-

753584

folate hydrolase

Mus musculus

O35409

-

753584

FOLH1

Homo sapiens

-

-

669595

FOLH1

Mus musculus

-

-

669595, 701258

GCP II

Homo sapiens

-

-

667114, 669776, 669801, 670397, 683948, 707124

GCP II

Mus musculus

-

-

670857

GCP II

Mus musculus C57/Bl

-

-

-

GCP II

Rattus norvegicus

-

-

667114, 668486, 669776, 669943

GCPII

Canis lupus familiaris

-

-

754377

GCPII

Homo sapiens

-

-

654179, 656468, 668484, 670363, 670817, 697394, 701206, 708479

GCPII

Homo sapiens

Q04609

-

668408, 670685, 696330, 699452, 731257, 752647, 752648, 752675, 752980, 753547, 753551, 753584, 754372, 754380, 754505, 755286

GCPII

Mus musculus

-

-

670406, 701258

GCPII

Mus musculus

O35409

-

753584, 754377

GCPII

Mus musculus

Q9CZR2

-

669923

GCPII

Procambarus clarkii

-

-

669932

GCPII

Rattus norvegicus

-

-

657162, 668484, 670363, 670406, 698502

GCPII

Rattus norvegicus

P70627

-

755361, 755508

GCPIII

Homo sapiens

-

-

670363, 708479

GCPIII

Mus musculus

Q9CZR2

-

669923

GCPIII

Rattus norvegicus

-

-

670363

glutamate carboxypeptidase II

Canis lupus familiaris

-

-

754377

glutamate carboxypeptidase II

Homo sapiens

-

-

697394, 701206, 708479

glutamate carboxypeptidase II

Homo sapiens

Q04609

-

696330, 699452, 752647, 752648, 752675, 752980, 753547, 753551, 753584, 754372, 754380, 754505, 755286

glutamate carboxypeptidase II

Mus musculus

-

-

701258

glutamate carboxypeptidase II

Mus musculus

O35409

-

753584, 754377

glutamate carboxypeptidase II

Rattus norvegicus

-

-

698502

glutamate carboxypeptidase II

Rattus norvegicus

P70627

-

755361, 755508

glutamate carboxypeptidase III

Homo sapiens

-

-

708479

glutamate carboxypeptidase III

Mus musculus

Q9CZR2

-

669923

GPCPII

Homo sapiens

-

-

668484

GPCPII

Rattus norvegicus

-

-

668484

N-acetylaspartylglutamate peptidase

Homo sapiens

-

-

668484

N-acetylaspartylglutamate peptidase

Rattus norvegicus

-

-

668484

N-Acetylated alpha-linked acidic dipeptidase

-

-

-

-

N-Acetylated alpha-linked acidic dipeptidase

Histoplasma capsulatum

-

-

731264

N-Acetylated alpha-linked acidic dipeptidase

Histoplasma capsulatum CDC105

-

-

-

N-Acetylated alpha-linked acidic dipeptidase

Homo sapiens

-

-

667114, 669595, 670817, 683948, 709440

N-Acetylated alpha-linked acidic dipeptidase

Mus musculus

-

-

669595

N-Acetylated alpha-linked acidic dipeptidase

Rattus norvegicus

-

-

667114, 669595, 669943

N-Acetylated-alpha-linked acidic dipeptidase

-

-

-

-

N-Acetylated-alpha-linked acidic dipeptidase

Mus musculus

Q9CZR2

-

669923

N-Acetylated-alpha-linked-acidic dipeptidase

-

-

-

-

N-Acetylated-alpha-linked-acidic dipeptidase

Rattus norvegicus

-

-

708400, 709605

NAAG peptidase

Homo sapiens

-

-

668484, 670363

NAAG peptidase

Mus musculus

Q9CZR2

-

669923

NAAG peptidase

Rattus norvegicus

-

-

668484, 669962, 670363

NAALADase

-

-

-

-

NAALADase

Histoplasma capsulatum

-

-

731264

NAALADase

Histoplasma capsulatum CDC105

-

-

-

NAALADase

Homo sapiens

-

-

654179, 667114, 668106, 669595, 670817, 683948, 708479, 709440, 710007

NAALADase

Mus musculus

-

-

669595, 701258

NAALADase

Mus musculus

Q9CZR2

-

669923

NAALADase

Rattus norvegicus

-

-

655290, 656455, 656609, 667114, 668486, 669595, 669943, 708400, 709605

PMSA

Homo sapiens

-

-

668154, 670219

PMSA

Mus musculus

-

-

701258

prostate specific membrane antigen

Homo sapiens

-

-

656634, 668866, 669595, 708479

prostate specific membrane antigen

Mus musculus

-

-

669595, 701258

Prostate-specific membrane antigen

-

-

-

-

Prostate-specific membrane antigen

Canis lupus familiaris

-

-

670740

Prostate-specific membrane antigen

Homo sapiens

-

-

654179, 667114, 668154, 669506, 670219, 670363, 670740, 670794, 670817, 701206, 707973, 707988, 708256, 708666, 709440, 709648, 709649, 709808, 710007, 710204, 710358, 710456, 710457, 710458, 710460, 710658

Prostate-specific membrane antigen

Homo sapiens

Q04609

-

670685, 709812, 710006, 753551, 753584

Prostate-specific membrane antigen

Macaca fascicularis

-

-

670740

Prostate-specific membrane antigen

Macaca mulatta

-

-

670740

Prostate-specific membrane antigen

Mus musculus

-

-

670740

Prostate-specific membrane antigen

Mus musculus

O35409

-

753584

PSMA

-

-

-

-

PSMA

Canis lupus familiaris

-

-

670740

PSMA

Homo sapiens

-

-

656377, 656634, 667114, 668866, 669506, 669595, 670363, 670740, 670794, 670817, 701206, 707973, 707988, 708256, 708325, 708666, 709440, 709648, 709649, 709808, 710007, 710204, 710358, 710456, 710457, 710458, 710460, 710658

PSMA

Homo sapiens

Q04609

-

670685, 709812, 710006, 753551, 753584

PSMA

Macaca fascicularis

-

-

670740

PSMA

Macaca mulatta

-

-

670740

PSMA

Mus musculus

-

-

669595, 670740

PSMA

Mus musculus

O35409

-

753584