3.4.17.13: Muramoyltetrapeptide carboxypeptidase
This is an abbreviated version!
For detailed information about Muramoyltetrapeptide carboxypeptidase, go to the full flat file.
Word Map on EC 3.4.17.13
-
3.4.17.13
-
peptidoglycan
-
murein
-
dd-carboxypeptidase
-
homari
-
gaffkya
-
muropeptide
-
sacculus
-
transpeptidation
-
sphaericus
-
udp-murnac-tetrapeptide
-
meso-diaminopimelic
- 3.4.17.13
- peptidoglycan
- murein
- dd-carboxypeptidase
- homari
-
gaffkya
-
muropeptide
-
sacculus
-
transpeptidation
- sphaericus
- udp-murnac-tetrapeptide
-
meso-diaminopimelic
Reaction
hydrolysis of the bond: N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-lysyl-/-D-alanine =
Synonyms
Carboxypeptidase II, Carboxypeptidase IIW, Carboxypeptidase, lysyl-D-alanine, Carboxypeptidase, muramoyltetrapeptide, cjj81176_0915, DacB, L,D-carboxypeptidase A, L-Lysyl-D-alanine carboxypeptidase, LD-Carboxypeptidase, LdcA, LdcA1, LdcA2, LdcB, muramoyltetrapeptide carboxypeptidase, peptidase U61, Pgp2, Spr0554
ECTree
3.4.17.13 Muramoyltetrapeptide carboxypeptidaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.17.13 - Muramoyltetrapeptide carboxypeptidase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GlcNAc-MurNAc tetrapeptide + H2O
?
substrate prepared from purified murein by lysozyme, cleaves specifically between meso-diaminopimelic acid and D-alanine
-
-
?
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2)-(L)-D-Ala + H2O
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) + (L)-D-Ala
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
L-Ala-gamma-D-Glu-meso-diaminopimelyl + D-Ala
N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-Lys-D-Ala + H2O
N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-Ala-D-glutamyl-6-carboxy-L-Lys + D-Ala
-
-
-
-
?
N-Acetylglucosamine-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
N-Acetylglucosamine-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
N-acetylmuramoyl-Ala-D-Glu-Dap-D-Ala + H2O
N-acetylmuramoyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelyl-D-Ala + H2O
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
peptidoglycan + H2O
?
the enzyme is involved in peptidoglycan recycling
-
-
?
UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
L-Ala-D-Gln-L-Lys-D-Ala + H2O
L-Ala-D-Gln-L-Lys + D-Ala
-
-
-
?
L-Ala-D-Gln-L-Lys-D-Ala + H2O
L-Ala-D-Gln-L-Lys + D-Ala
-
-
-
?
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2)-(L)-D-Ala + H2O
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) + (L)-D-Ala
-
-
-
?
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2)-(L)-D-Ala + H2O
L-Ala-D-Glu-(L)-meso-diaminopimelic-acid-(omegaNH2) + (L)-D-Ala
-
-
-
?
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
L-Ala-gamma-D-Glu-meso-diaminopimelyl + D-Ala
-
-
-
-
?
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
L-Ala-gamma-D-Glu-meso-diaminopimelyl + D-Ala
-
-
-
?
L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
L-Ala-gamma-D-Glu-meso-diaminopimelyl + D-Ala
-
-
-
?
Modified muropeptides + H2O
?
-
all tested disaccharide-tetrapeptide monomeric muropeptides modified at position 4, monomers with m-lanthionine, but not with L-ornithine, instead of m-diaminopimelic acid at position 3
-
-
?
Modified muropeptides + H2O
?
-
all tested disaccharide-tetrapeptide monomeric muropeptides modified at position 4, monomers with m-lanthionine, but not with L-ornithine, instead of m-diaminopimelic acid at position 3
-
-
?
muropeptides + H2O
?
-
-
incubation of isoform Pgp2 with peptidglucan from the Pgp2 mutant strain results in a 94% reduction of monomeric tetrapeptides, a 68% reduction in dimeric tetrapeptides, and a 47% reduction in trimeric tetrapeptides
-
?
muropeptides + H2O
?
-
incubation of isoform LcdB with peptidoglucan from the LcdB mutant strain leads to almost quantitative digestion of peptidoglucan tetrapeptides with a carboxy-terminal D-Ala producing the tripeptides
-
?
muropeptides + H2O
?
-
incubation of isoform LcdB with peptidoglucan from the LcdB mutant strain leads to almost quantitative digestion of peptidoglucan tetrapeptides with a carboxy-terminal D-Ala producing the tripeptides
-
?
N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala + H2O
N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala
-
-
-
?
N-acetylmuramoyl-L-Ala-D-Glu-L-Lys-D-Ala + H2O
N-acetylmuramoyl-L-Ala-D-Glu-L-Lys + D-Ala
-
-
-
?
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelyl-D-Ala + H2O
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
-
-
-
?
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelyl-D-Ala + H2O
N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
Escherichia coli W3110 / ATCC 27325
-
-
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
enzyme can also replace the terminal D-alanine with a variety of amino acids with D-asymmetric centers for transpeptidation
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-Ala-D-Glu-Dap-D-Ala + H2O
UDP-N-acetylmuramyl-Ala-D-Glu-Dap + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
-
-
-
?
UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala + H2O
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-diaminopimelate + D-Ala
-
-
-
?
additional information
?
-
-
enzyme also has D-amino acid exchange activity
-
-
?
additional information
?
-
-
isoform Pgp2 is a LD-carboxypeptidase cleaving monomeric and cross-linked disaccharide tetrapeptides to tripeptides
-
-
?
additional information
?
-
-
no direct effect of LD-carboxypeptidase on macromolecular murein metabolism
-
-
?
additional information
?
-
-
the enzyme is involved in cell wall synthesis
-
-
?
additional information
?
-
-
the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala
-
-
?
additional information
?
-
-
no direct effect of LD-carboxypeptidase on macromolecular murein metabolism
-
-
?
additional information
?
-
-
the enzyme is involved in cell wall synthesis
-
-
?
additional information
?
-
-
the enzyme is specific for D-Ala and requires a substrate chain length of 4 monomers, no or poor activity with L-Ala-gamma-D-Glu-L-Lys-L-Ala, D-Glu-L-Lys-D-Ala and L-Lys-D-Ala
-
-
?
additional information
?
-
-
cleaves the peptide side chain of peptidoglycan between L-Lys and D-Ala
-
-
?
additional information
?
-
-
the enzyme is involved in cell wall synthesis
-
-
?
additional information
?
-
enzyme prefers tetrapeptide substrates and can discriminate between tetrapeptide and pentapeptide substrates, but is less selective toward the N-terminal sugar moiety. No substrate: UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala, poor substrate: N-acetylmuramyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala
-
-
?
additional information
?
-
enzyme prefers tetrapeptide substrates and can discriminate between tetrapeptide and pentapeptide substrates, but is less selective toward the N-terminal sugar moiety. No substrate: UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala, poor substrate: N-acetylmuramyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala
-
-
?
additional information
?
-
-
enzyme prefers tetrapeptide substrates and can discriminate between tetrapeptide and pentapeptide substrates, but is less selective toward the N-terminal sugar moiety. No substrate: UDP-N-acetylmuramyl-L-Ala-gamma-D-Glu-meso-diaminopimelyl-D-Ala-D-Ala, poor substrate: N-acetylmuramyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala
-
-
?
additional information
?
-
-
incorporation of diaminopimelate into cell walls
-
-
?
additional information
?
-
the enzyme is a serine peptidase which cleaves between the L- and D-amino acids of bacterial peptidoglycan
-
-
?
additional information
?
-
-
the enzyme is a serine peptidase which cleaves between the L- and D-amino acids of bacterial peptidoglycan
-
-
?
additional information
?
-
no activity with substrate L-Ala-D-Gln-L-Lys-L-Ala
-
-
?
additional information
?
-
-
no activity with substrate L-Ala-D-Gln-L-Lys-L-Ala
-
-
?
additional information
?
-
no activity with substrate L-Ala-D-Gln-L-Lys-L-Ala
-
-
?
