3.4.15.4: Peptidyl-dipeptidase B

This is an abbreviated version!
For detailed information about Peptidyl-dipeptidase B, go to the full flat file.

Reaction

release of a C-terminal dipeptide or exceptionally a tripeptide =

Synonyms

Atrial di-(tri-)peptidyl carboxyhydrolase, Atrial dipeptidyl carboxyhydrolase, Atrial peptide convertase, Atriopeptin convertase, Dipeptidase, peptidyl-, B, Dipeptidyl carboxyhydrolase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.15 Peptidyl-dipeptidases

                3.4.15.4 Peptidyl-dipeptidase B

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Results	in table
1	CAS Registry Number
11	Inhibitors
16	KM Value [mM]
2	Localization
2	Metals/Ions
1	Molecular Weight [Da]
5	Organism
1	pH Optimum
1	pH Range
1	Purification (Commentary)
1	Reaction
1	Reaction Type
5	Reference
4	Source Tissue
1	Specific Activity [micromol/min/mg]
26	Substrates and Products (Substrate)
6	Synonyms
1	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.4.15.4 - Peptidyl-dipeptidase B

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2-aminobenzoyl-Gly-Ala-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Ala + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728, 28730

-

-

?

2-aminobenzoyl-Gly-Asn-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Asn + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728

-

-

?

2-aminobenzoyl-Gly-Asp-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Asp + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728

-

-

?

2-aminobenzoyl-Gly-Lys-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Lys + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728

-

-

?

2-aminobenzoyl-Gly-Ser-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Ser + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728

-

-

?

2-aminobenzoyl-Gly-Thr-(4-nitro)Phe-Arg + H2O

2-aminobenzoyl-Gly-Thr + 4-nitro-L-phenylalanyl-L-arginine

Bos taurus

-

-

28728, 28730

-

-

?

Atriopeptin II + H2O

Atriopeptin I + ?

2 entries

Atriopeptin II peptide Ser103-Arg125 + H2O

Atriopeptin I peptide Ser103-Ser123 + Phe-Arg

Bos taurus

-

-

28730

-

28730

?

Atriopeptin III peptide Ser103-Tyr126 + H2O

Atriopeptin I + Phe-Arg-Tyr

Bos taurus

-

-

28730

-

28730

?

Benzoyl-Asn-Ser-Phe-Arg-Tyr + H2O

Benzoyl-Asn-Ser-Phe + Arg-Tyr

Bos taurus

-

-

28730

successive dipeptidyl cleavage after longer incubation yielding benzoyl-Asn + Ser-Phe

28730

?

Benzoyl-Gly-Asn-Ser + H2O

?

Bos taurus

-

-

28729

-

-

?

benzoyl-Gly-Gly-Phe-Arg + H2O

benzoyl-Gly-Gly + Phe-Arg

Bos taurus

-

-

28729

-

-

?

benzoyl-Gly-His-Gly + H2O

benzoyl-Gly + His-Gly

Bos taurus

-

-

28727

-

-

?

benzoyl-Gly-His-Leu + H2O

?

Bos taurus

-

-

28727, 28729

-

-

?

Benzoyl-Gly-Phe-Ser-Arg + H2O

?

Bos taurus

-

-

28728, 28729

-

-

?

benzoyl-Gly-Ser-Phe-Arg + H2O

benzoyl-Gly-Ser + Phe-Arg

Bos taurus

-

-

28728, 28729

-

-

?

[Mercaptopropionyl105,(D)Ala107]-atriopeptinIII-NH2 peptide + H2O

Analog(1-18) + Phe-Arg-Tyr-NH2

Bos taurus

-

enzyme acts exclusively as tripeptidyl carboxyhydrolase

28730

-

28730

?

additional information

?

-

2 entries

Atriopeptin II + H2O

Atriopeptin I + ?

Bos taurus

-

-

28727

-

28727

?

Atriopeptin II + H2O

Atriopeptin I + ?

Bos taurus

-

atriopepin I is not a substrate

28729

sequential cleavage of Asn-Ser does not occur, ? is Phe-Arg

28729

?

additional information

?

-

Bos taurus

-

generally restricted to the release of dipeptides. In contrast to peptidyl-dipeptidase A (EC 3.4.15.1) it shows no action on angiotensin I. Conversely, peptidyl-dipeptidase A is unable to release Phe-Arg from the C-terminus of atriopeptin II

28730

-

-

?

additional information

?

-

Bos taurus

-

not: benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2

28730

-

-

?