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3.4.15.4: Peptidyl-dipeptidase B

This is an abbreviated version!
For detailed information about Peptidyl-dipeptidase B, go to the full flat file.

Word Map on EC 3.4.15.4

Reaction

release of a C-terminal dipeptide or exceptionally a tripeptide =

Synonyms

Dipeptidyl carboxyhydrolase, Atriopeptin convertase, Atrial di-(tri-)peptidyl carboxyhydrolase, Dipeptidase, peptidyl-, B, Atrial dipeptidyl carboxyhydrolase, Atrial peptide convertase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.15 Peptidyl-dipeptidases
                3.4.15.4 Peptidyl-dipeptidase B

Inhibitors

Inhibitors on EC 3.4.15.4 - Peptidyl-dipeptidase B

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
2-D-Methylsuccinyl-L-Pro
-
-
3-Mercaptopropanoyl-L-Pro
-
-
Benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2
-
competitive inhibitor of 2-aminobenzoyl-Gly-Ala-Phe(4-nitro)-Arg hydrolysis and benzoyl-Asn-Ser-Phe-Arg-Tyr hydrolysis
bradykinin potentiating factor
-
-
-
D-2-Methyl-3-mercaptopropanoyl-L-Pro
-
i.e. captopril
DTT
-
-
mercaptoethanol
-
-
additional information
-
marked substrate inhibition with benzoyl-Gly-His-Leu, but little or no substrate inhibition with benzoyl-Gly-His-Gly; the enzyme is 5500 times less sensitive to D-Cys-L-Pro, the very potent inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1)
-