3.4.15.4: Peptidyl-dipeptidase B
This is an abbreviated version!
For detailed information about Peptidyl-dipeptidase B, go to the full flat file.
Reaction
release of a C-terminal dipeptide or exceptionally a tripeptide =
Synonyms
Atrial di-(tri-)peptidyl carboxyhydrolase, Atrial dipeptidyl carboxyhydrolase, Atrial peptide convertase, Atriopeptin convertase, Dipeptidase, peptidyl-, B, Dipeptidyl carboxyhydrolase
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Inhibitors
Inhibitors on EC 3.4.15.4 - Peptidyl-dipeptidase B
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Benzoyl-Asn-Ser-Phe-Arg-Tyr-NH2
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competitive inhibitor of 2-aminobenzoyl-Gly-Ala-Phe(4-nitro)-Arg hydrolysis and benzoyl-Asn-Ser-Phe-Arg-Tyr hydrolysis
additional information
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marked substrate inhibition with benzoyl-Gly-His-Leu, but little or no substrate inhibition with benzoyl-Gly-His-Gly; the enzyme is 5500 times less sensitive to D-Cys-L-Pro, the very potent inhibitor of angiotensin I-converting enzyme (EC 3.4.15.1)
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EDTA
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activity is restored by addition of Co2+, Zn2+ and Mn2+, but not by Cu2+, Mg2+, Ca2+ or Cd2+