3.4.14.2: dipeptidyl-peptidase II
This is an abbreviated version!
For detailed information about dipeptidyl-peptidase II, go to the full flat file.
Word Map on EC 3.4.14.2
-
3.4.14.2
-
glucagon-like
-
glp-1
-
mellitus
-
dpp-iv
-
incretins
-
peptidase-4
-
peptide-1
-
lysosomal
-
dipeptides
-
antidiabetic
-
glycemic
-
cathepsins
-
prolyl
-
insulinotropic
-
linagliptin
-
vildagliptin
-
metformin
-
glucose-dependent
-
glucagon
-
postprandial
-
iv-deficient
-
hypoglycemia
-
glucose-lowering
-
exopeptidase
-
gip
-
sulfonylurea
-
aminopeptidases
-
iv-like
-
antihyperglycemic
-
repopulation
-
3.4.14.5
-
proline-specific
-
oligopeptidase
-
saxagliptin
-
gelatinase
-
incretin-based
-
alogliptin
-
thiazolidinediones
-
liraglutide
-
excursion
-
gliptins
-
sodium-glucose
-
retrorsine
-
exenatide
-
post-proline
-
diprotin
-
tripeptidyl
-
crevicular
-
analysis
-
medicine
- 3.4.14.2
-
glucagon-like
- glp-1
- mellitus
- dpp-iv
- incretins
-
peptidase-4
- peptide-1
- lysosomal
- dipeptides
-
antidiabetic
-
glycemic
- cathepsins
-
prolyl
-
insulinotropic
- linagliptin
- vildagliptin
- metformin
-
glucose-dependent
- glucagon
-
postprandial
-
iv-deficient
- hypoglycemia
-
glucose-lowering
-
exopeptidase
- gip
- sulfonylurea
- aminopeptidases
-
iv-like
-
antihyperglycemic
-
repopulation
-
3.4.14.5
-
proline-specific
-
oligopeptidase
- saxagliptin
- gelatinase
-
incretin-based
- alogliptin
- thiazolidinediones
- liraglutide
-
excursion
-
gliptins
-
sodium-glucose
- retrorsine
-
exenatide
-
post-proline
- diprotin
-
tripeptidyl
-
crevicular
- analysis
- medicine
Reaction
release of an N-terminal dipeptide, Xaa-Yaa-/-, preferentially when Yaa is Ala or Pro. Substrates are oligopeptides, preferentially tripeptides =
Synonyms
brain dipeptidyl aminopeptidase A, carboxytripeptidase, dipeptidyl aminopeptidase II, dipeptidyl arylamidase II, dipeptidyl peptidase, dipeptidyl peptidase 2, dipeptidyl peptidase II, dipeptidyl-aminopeptidase II, dipeptidylpeptidase II, DP II, DPP, DPP II, DPP-II, DPP2, DPP7, DPPII, DPPV, fibroblast activation protein alpha, GPA, More, peptidase, dipeptidyl, II, QPP, quiescent cell proline dipeptidase, seprase
ECTree
3.4.14.2 dipeptidyl-peptidase IIAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.4.14.2 - dipeptidyl-peptidase II
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Ala-Ala-2-nitroanilide + H2O
Ala-Ala + 2-nitroaniline
-
low activity
-
?
Ala-Ala-Ala-Ala + H2O
Ala-Ala + Ala-Ala
-
39% activity compared to Met-Ala-Ser
-
-
?
Ala-Ala-p-nitroanilide + H2O
Ala-Ala + p-nitroaniline
-
481% activity compared to Gly-Pro-7-amido-4-methylcoumarin
-
-
?
Arg-Pro-2-naphthylamide + H2O
Arg-Pro + 2-naphthylamine
-
27% of the activity with Phe-Pro-2-naphthylamide
-
-
?
Gly-Ala-7-amido-4-methylcoumarin + H2O
Gly-Ala + 7-amino-4-methylcoumarin
-
-
?
Gly-Pro-4-methylcoumarin 7-amide + H2O
Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
Gly-Pro-Gly-Gly + H2O
Gly-Pro + Gly-Gly
-
16% activity compared to Met-Ala-Ser
-
-
?
L-Lys-L-Ala-5-chloro-1-anthraquinonylhydrazide-2HBr + H2O
L-Lys-L-Ala + 5-Cl-1-anthraquinonylhydrazine + HBr
-
i.e. Lys-Ala-CAH, synthetic substrate for colorimetric assay
i.e. CAH, forms a highly insoluble, deeply colored hydrazone when coupled to an aromatic aldehyde, e.g. 4-nitrobenzaldehyde or piperonal, useful for histochemical detection of the enzyme
?
Lys-Pro-7-amido-4-methylcoumarin + H2O
Lys-Pro + 7-amino-4-methylcoumarin
-
-
?
Nle-Pro-7-amido-4-methylcoumarin + H2O
Nle-Pro + 7-amino-4-methylcoumarin
-
-
?
Phe-Pro-4-methylcoumarin 7-amide + H2O
Phe-Pro + 7-amino-4-methylcoumarin
-
-
-
-
?
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
Ala-Pro + amino-4-trifluoromethylcoumarin
-
-
?
Ala-Pro-amino-4-trifluoromethylcoumarin + H2O
Ala-Pro + amino-4-trifluoromethylcoumarin
-
-
-
?
Arg-Ala-2-naphthylamide + H2O
Arg-Ala + 2-naphthylamine
-
11% of the activity with Phe-Pro-2-naphthylamide
-
-
?
Arg-Pro-p-nitroanilide + H2O
Arg-Pro + p-nitroaniline
-
591% activity compared to Gly-Pro-7-amido-4-methylcoumarin
-
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
-
specific for proline
-
?
Gly-Pro-4-nitroanilide + H2O
Gly-Pro + 4-nitroaniline
-
specific for proline
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
-
-
-
?
Gly-Pro-7-amido-4-methylcoumarin + H2O
Gly-Pro + 7-amino-4-methylcoumarin
-
100% activity
-
-
?
Gly-Pro-p-nitroanilide + H2O
Gly-Pro + p-nitroaniline
-
562% activity compared to Gly-Pro-7-amido-4-methylcoumarin
-
-
?
L-Lys-L-Ala-7-amido-4-methylcoumarin + H2O
L-Lys-L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Lys-L-Ala-7-amido-4-methylcoumarin + H2O
L-Lys-L-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
Lys-Ala-2-(4-methoxy)-naphthylamide Lys-Ala-4-methoxy-2-naphthylamide + H2O
?
-
-
-
-
?
Lys-Ala-2-(4-methoxy)-naphthylamide Lys-Ala-4-methoxy-2-naphthylamide + H2O
?
-
-
-
-
?
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
-
-
-
?
Lys-Ala-2-naphthylamide + H2O
Lys-Ala + 2-naphthylamine
-
15% of the activity with Phe-Pro-2-naphthylamide
-
-
?
Lys-Ala-4-methylcoumaryl-7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
Lys-Ala-4-methylcoumaryl-7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
-
-
?
Lys-Ala-4-methylcoumaryl-7-amide + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
-
-
?
Lys-Ala-7-amido-4-methylcoumarin + H2O
Lys-Ala + 7-amino-4-methylcoumarin
-
38% activity compared to Gly-Pro-7-amido-4-methylcoumarin
-
-
?
Lys-Pro-2-naphthylamide + H2O
Lys-Pro + 2-naphthylamine
-
46% of the activity with Phe-Pro-2-naphthylamide
-
-
?
additional information
?
-
-
Pro and Arg are the preferred penultimate residues
-
-
?
additional information
?
-
-
no hydrolysis occurs if either the carboxyl group or the amino group of otherwise susceptible tripeptides is blocked. Tetrapeptides, tripeptide esters and dipeptides are not attacked
-
-
?
additional information
?
-
-
Ala and Pro are the preferred residues in the P1 position
-
-
?
additional information
?
-
Ala and Pro are the preferred residues in the P1 position
-
-
?
additional information
?
-
-
no activity with Ala-Ala-Ala-Ala-Ala, Arg-Pro-Lys-Pro (substance P 1-4), and Arg-Pro-Pro-Gly-Phe (bradikinin1-5)
-
-
?
additional information
?
-
-
the enzyme contributes to the alveolar macrophage's proteolytic capabilities
-
-
?
additional information
?
-
-
the enzyme contributes to the alveolar macrophage's proteolytic capabilities
-
-
?
additional information
?
-
-
hydrolyzes specifically N-terminal X-alanine or X-proline from their respective arylamides and from tripeptides or tetrapeptides, but not from pentapeptides
-
-
?
additional information
?
-
-
possible role of the mast cell enzyme in remodelling of connective tissue
-
-
?
additional information
?
-
-
the enzyme may play a role in the segregation and degradation of specific regions of normal lens fiber cells
-
-
?
additional information
?
-
-
Ala and Pro are the preferred residues in the P1 position
-
-
?
additional information
?
-
-
Ala and Pro are the preferred residues in the P1 position
-
-
?
additional information
?
-
-
no activity with Gly-Arg-7-amido-4-methylcoumarin, Arg-Arg-7-amido-4-methylcoumarin, and Ala-Arg-7-amido-4-methylcoumarin
-
-
?
